In this paper, the Cauchy problem of the 3D compressible Navier-Stokes equations with degenerate viscosities and far field vacuum is considered. We prove that the L ∞ norm of the deformation tensor D(u) (u: the velocity of fluids) and the L 6 norm of ∇ log ρ (ρ: the mass density) control the possible blow-up of regular solutions. This conclusion means that if a solution with far field vacuum to the Cauchy problem of the compressible Navier-Stokes equations with degenerate viscosities is initially regular and loses its regularity at some later time, then the formation of singularity must be caused by losing the bound of D(u) or ∇ log ρ as the critical time approaches; equivalently, if both D(u) and ∇ log ρ remain bounded, a regular solution persists.