Vapor-based hybrid grafting of heparin-like coating for dialysis membranes with enhanced hemocompatibility

Zhang, Ruhao; Shi, Xiao Li; Huang, X.; Zhao, Jiaqi; Lu, Peng; He, Yedong; Liu, Fu; Liu, Wenna; Ye, Yumin

doi:10.1016/j.memsci.2023.121963

Cited by 5 publications

(3 citation statements)

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“…58 For instance, a heparin-like coating consisting of PMAA grafted on PMAA-co-ethylene glycol dimethacrylate (PMAA-co-EGDMA) on a polylactide (PLA) dialysis membrane was synthesized using iCVD. 54 The resulting membrane retained its hydrophilicity with a static water contact angle of 33°and less than 10% reduction in water flux, indicating reasonable retention of permeability. The copolymer-grafted membrane showed a higher clearance rate for urea (147.5 mL/min) and lysozyme (103.5 mL/min) compared to the pristine membrane (89.1 mL/min for urea and 62.4 mL/min for lysozyme), yet its clearance rate for bovine serum albumin (BSA) was reduced compared to that of the pristine membrane.…”

Section: Antifouling Surfacesmentioning

confidence: 93%

“…A sizable library of antifouling polymer coatings has been developed using iCVD over the past decade, including poly(2-hydroxyethyl methacrylate) (HEMA), poly(vinylpyrrolidone) (VP), − poly(hydroxypropyl methacrylate) (HPMA), poly(methacrylic acid) (MAA), − zwitterionic polymers, , and amphiphilic polymers . For instance, a heparin-like coating consisting of PMAA grafted on PMAA- co -ethylene glycol dimethacrylate (PMAA- co -EGDMA) on a polylactide (PLA) dialysis membrane was synthesized using iCVD . The resulting membrane retained its hydrophilicity with a static water contact angle of 33° and less than 10% reduction in water flux, indicating reasonable retention of permeability.…”

Section: Antifouling Surfacesmentioning

confidence: 99%

“…This derivatization reaction has been widely adopted in recent years by researchers within and beyond the CVD polymerization community to obtain zwitterionic polymers . Using the iCVD zwitterionic polymer coatings, delicate substrates, such as ultrafiltration, nanofiltration, and reverse osmosis (RO) membranes, , can be rendered antifouling without compromising their performance. Since its invention, the two-step synthesis scheme has been further leveraged to obtain a broader palette of zwitterionic polymer chemistries with different biological functions .…”

Section: Antifouling Surfacesmentioning

confidence: 99%

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Advances in Antibacterial Polymer Coatings Synthesized via Chemical Vapor Deposition

Shu,

Chen,

Yang

2024

Chem Bio Eng.

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Biofouling is a major issue across various industries ranging from healthcare to the production of food and water and transportation. Biofouling is often induced or mediated by environmental microbes, such as bacteria. Therefore, developing antibacterial coatings has been an essential focus of recent research on functional polymer thin films. To achieve high film quality, vapor-phase techniques represent promising alternatives to traditional solution-based methods, especially for the design and synthesis of antibacterial polymer coatings, as they enable highly uniform, chemically precise, and substrate-independent coatings. This Perspective examines the potential of vapor-phase polymerization techniques to create novel antibacterial polymer coatings. Current advancements in the design of antifouling, bactericidal, antibiofilm, and multifunctional coatings via vapor-phase techniques are organized based on their action mechanisms and design principles. The opportunities and challenges associated with implementing vapor-phase polymerization for developing antibacterial coatings are highlighted.

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Section: Antifouling Surfacesmentioning

confidence: 93%