Vapor Phase Synthesis of Annelated Pyridines over Metal Modified Zeolite Beta

Macharla, Arun Kumar; Reddy, Marri Mahender; Swamy, Peraka; Mameda, Naresh; Kodumuri, Srujana; Kandepi, V. V. Krishna Mohan; Narender, Nama

doi:10.1007/s10562-015-1598-0

Cited by 5 publications

(2 citation statements)

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“…However, they produce less OA with several byproducts, and the catalytic scientists reported major problems as these catalytic systems have complicated and expensive processes to separate the main product. 10 Recently, green catalytic systems have focused on increasing economic benefits and reducing environmental threats mesoporous MCM-41 materials have not been directly used for their catalytic applications because their acidities and hydrothermal stabilities are low. 11 Thus, incorporation of Al into mesoporous silica walls with improving the surface acidity and enhanced hydrothermal stability has been clearly reported.…”

Section: Introductionmentioning

confidence: 99%

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Highly Selective Synthesis of Octahydroaminoacridine over Mesoporous ZnAlMCM-41 Catalysts

Selvaraj

Assiri

2020

Ind. Eng. Chem. Res.

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A very ecofriendly heterogeneous catalytic method has been used for the highly selective synthesis of octahydroaminoacridine/1,2,3,4,5,6,7,8-octahydroacridin-9-amine (OA) by a single-step vapor phase cyclization of cyclohexanone (CHCO) with a mixture of formamide (HCONH2) and ammonia (NH3) over different nanoporous catalysts, for example, mesoporous solid acid catalysts, ZnAlMCM-41, AlMCM-41, and ZnMCM-41, and microporous catalysts, for example, USY, Hβ, HZSM-5, and H-mordenite. In pharmaceutical companies, the main product, OA, is used as a drug intermediate in the production of tacrine that is a licensed drug, which is used for the treatment of Alzheimer’s disease. In order to determine their catalytic stabilities, recyclable mesoporous ZnAlMCM-41 catalysts have been reused in this reaction. To find an optimal parameter for highly selective synthesis of OA, various reaction parameters have been extensively investigated for this reaction. Additionally, an important byproduct, 1,2,3,4,5,6,7,8-octahydroacridine, is also formed by deamination of OA. The mesoporous ZnAlMCM-41(75) produces 92% OA selectivity with 100% CHCO conversion at 0.5 h–1 weight hourly space velocity and 340 °C with a feed ratio of CHCO/HCONH2/NH3 = 2:1:5. Interestingly, we have observed from the catalytic results of all the catalysts used for the single-step selective synthesis of OA that the ZnAlMCM-41(75) catalyst has higher OA selectivity with exceptional catalytic activity than other microporous and mesoporous catalysts.

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Section: Introductionmentioning

confidence: 99%

“…Therefore, in the synthesis of OA, many solid acid catalysts, for example, microporous zeolites, are used. However, they produce less OA with several byproducts, and the catalytic scientists reported major problems as these catalytic systems have complicated and expensive processes to separate the main product …”

Section: Introductionmentioning

confidence: 99%