Varenicline and related interventions on smoking cessation: A systematic review and network meta-analysis

Guo, Kangle; Zhou, Liying; Shang, Xue; Yang, Chaoqun; Fenfen, E; Wang, Yan; Xu, Meng; Wu, Yanan; Li, Yanfei; Li, Meixuan; Yang, Kehu; Li, Xiuxia

doi:10.1016/j.drugalcdep.2022.109672

Cited by 15 publications

(7 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among published studies, Vogeler et al and Zhong et al pointed out that combined treatment with varenicline and bupropion can significantly improve the smoking cessation rates at the end of treatment compared with single treatment with varenicline 29,30 . The research by Guo et al also supports our conclusion 31 . However, Siskind et al showed that varenicline + NRT ranked first in achieving sustained abstinence 32 .…”

Section: Discussionsupporting

confidence: 82%

“…In 2013, Cahill et al conducted a systematic review and meta‐analysis on pharmacological interventions for smoking cessation, which included different types of medications and excluded smokers with specific diseases 14 . In 2022, Guo et al conducted a systematic review and network meta‐analysis on varenicline and related smoking cessation interventions, which confirmed the superiority of varenicline for smoking cessation 31 . In contrast, our study only included pharmacological interventions and excluded any behavioural intervention measures.…”

Section: Discussionmentioning

confidence: 64%

“…For all interventions and associated pairwise comparisons, the network meta- 29,30 The research by Guo et al also supports our conclusion. 31 However, Siskind et al…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Efficacy and safety of antidepressants for smoking cessation: A systematic review and network meta‐analysis

et al. 2023

Self Cite

View full text Add to dashboard Cite

To evaluate the effectiveness, safety and tolerability of antidepressants in helping smokers quit tobacco dependence, five databases were searched for randomized controlled trials (RCT S ) on different antidepressant interventions involving smoking cessation in populations (September 2022). The STATA 15.1 software was used to perform network meta-analysis. The Cochrane bias risk tool was used to assess the risk of bias, and CINeMA was used to evaluate the evidence credibility for the effect of different interventions on smoking cessation. In all, 107 RCTs involving 42 744 patients were included. Seven studies were rated as having a low risk of bias. All trials reported 18 interventions and 153 pairwise comparisons were generated. The network meta-analysis showed that compared with placebo, varenicline + bupropion (OR = 3.53, 95% CI [2.34, 5.34]), selegiline + nicotine replacement therapy (NRT)

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 64%

See 1 more Smart Citation

Efficacy and safety of antidepressants for smoking cessation: A systematic review and network meta‐analysis

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

“…Clinical protocols should be developed to identify high-risk smokers and provide them with more intensive interventions. Medications such as nicotine and varenicline should be explored as potential options to reduce complications in smokers undergoing surgery [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Predictive Factors of Functional Outcomes and Quality of Life in Patients with Ankle Fractures: A Systematic Review

Lorente,

Pelaz,

Palacios

et al. 2024

JCM

View full text Add to dashboard Cite

Background: Evaluating the predictors of unfavorable outcomes in patients with ankle fractures is crucial for identifying high-risk patients and implementing personalized treatment strategies. This study aimed to analyze factors that influence quality of life in patients with ankle fractures. Methods: Four databases were consulted. The main outcomes were functionality and quality of life scales combined using the standard mean difference (SMD) (Review Manager 5.4). Results: Eight studies with 2486 patients were included. A significant correlation was found between female sex and worse functionality scores (beta 4.15, 95% CI 1.84–6.46). Additionally, older age was correlated with worse functionality scores (beta −0.24, 95% CI −0.29 to −0.19). Patients with diabetes or metabolic syndrome also had worse outcomes (SMD 0.27, 95% CI 0.18–0.36). High BMI and obesity were also associated with worse quality of life scores (beta 2.62, 95% CI 0.77–4.48). Smokers had greater disability in the analyzed scales (SMD 0.22, 95% CI 0.05–0.39). No significant differences were observed with respect to syndesmotic involvement. Conclusions: Age, sex, diabetes, high BMI, and smoking negatively impact functional outcomes and quality of life in patients with ankle fractures.

show abstract

“…Research has shown that varenicline can effectively increase the CAR among smokers ( 2 , 7 ). However, in CHSCs, cessation medications remain inaccessible due to high costs and inadequate insurance coverage.…”

Section: Discussionmentioning

confidence: 99%

Assessing the Effectiveness of a Community-Based Smoking Cessation Intervention — Shenzhen City, Guangdong Province, China, 2022

Lin¹,

Yan²,

Xie³

et al. 2023

China CDC Weekly

View full text Add to dashboard Cite

What is already known about this topic? Research on community-based smoking cessation interventions in China is still in its early stages. Most existing studies have focused on a limited number of communities and have primarily examined interventions conducted by study teams rather than broader community initiatives. What is added by this report? The three-month continuous abstinence rate for the intervention group (21.61%) was significantly higher than that for the control group (8.98%). Comprehensive community-based smoking cessation interventions, administered by trained physicians at community health service centers and supported by community workers, have shown effectiveness in improving a variety of outcomes among community smokers. What are the implications for public health practice? The feasibility and effectiveness of comprehensive community-based smoking cessation interventions make them a valuable addition to existing cessation services in China. Wider implementation of these interventions should be pursued as a complementary approach to current efforts to reduce smoking rates in China.

show abstract

Varenicline and related interventions on smoking cessation: A systematic review and network meta-analysis

Cited by 15 publications

References 61 publications

Efficacy and safety of antidepressants for smoking cessation: A systematic review and network meta‐analysis

Efficacy and safety of antidepressants for smoking cessation: A systematic review and network meta‐analysis

Predictive Factors of Functional Outcomes and Quality of Life in Patients with Ankle Fractures: A Systematic Review

Assessing the Effectiveness of a Community-Based Smoking Cessation Intervention — Shenzhen City, Guangdong Province, China, 2022

Contact Info

Product

Resources

About