Varenicline-induced drug eruption with resulting palmar/plantar hyperhidrosis and dysesthesia

Nicholas, Matilda W.; Isenstein, Arin; Dasher, David; Granko, Robert P.; Lugo-Somolinos, Aída; Groben, Pamela A.; Morrell, Dean S.

doi:10.1016/j.jaad.2009.04.037

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…Generalized severe rash and fever started 5-7 days after taking varenicline, was seen in these cases. The eruption resulting palmar/plantar hyperhidrosis and dysesthesia is also reported [14]. Our patient did not revealed systemic symptoms and acneiform eruption was occured on the upper part of the body.…”

Section: Discussionsupporting

confidence: 62%

Acneiform Eruption Caused By Varenicline Tartrate: A Case Report

2015

J Turk Acad Dermatol

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Observation: Drug-induced acneiform cutaneous eruptions are chronic rare reactions, have seen within the weeks or months after taking drug. Although many drugs may cause this reaction, corticosteroids are the most frequent. Varenicline tartrate has taken place in clinical practice as a helper drug for smoking cessation. Acneiform rash is a rare side effect of varenicline. Here, we present 32-year-old woman with erithymateous papuls and papulopustuls on her proximal trunks who has taken the varenicline tartarate since 2 months.

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Section: Discussionsupporting

confidence: 62%

Acneiform Eruption Caused By Varenicline Tartrate: A Case Report

2015

J Turk Acad Dermatol

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“…It has a relatively low molecular weight of 211.267 g/mol . Adverse cutaneous drug reactions to varenicline are rare, mainly consisting of AGEP in 3 previously reported cases , and 2 patients with maculopapular eruptions . The characteristic features of patients with varenicline‐induced AGEP are summarized in Table S2 .…”

Section: Discussionmentioning

confidence: 99%

“…Acute generalized exanthematous pustulosis (AGEP) is one of the most frequently reported adverse skin reactions to this drug . However, there are no previously published cases with varenicline‐induced AGEP or other skin conditions and a positive patch test reaction . We herein present 2 patients with varenicline‐induced AGEP, confirmed by patch testing in 1 of them.…”

mentioning

confidence: 84%

Varenicline‐induced acute generalized exanthematous pustulosis confirmed by patch testing

et al. 2017

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Fatality following a suicidal overdose with varenicline

et al. 2012

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The smoking cessation agent varenicline acts as a partial agonist on α(4)β(2) nicotinic acetylcholine receptors. Although debated, several reports have linked varenicline therapy to an increased risk of suicidal thoughts and/or suicide. In addition, several non-fatal overdose cases have been reported. In this report, we utilised a sample preparation procedure suitable for postmortem samples and gas chromatography coupled to mass spectrometry to analyse samples obtained from a suicidal case in which ingestion of an overdose of varenicline had occurred. Extremely high concentrations of varenicline (>250 ng/ml) were detected in the blood of the deceased, in addition to high concentrations in urine and vitreous humour. To the best of our knowledge, similar high concentrations have not been reported yet. Although, with respect to the mechanism of death in this case, confounding factors were concomitant ethanol consumption and, importantly, potentially fatal hypothermia, this is the first report of a fatality associated with the ingestion of an overdose of varenicline.

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Varenicline-induced drug eruption with resulting palmar/plantar hyperhidrosis and dysesthesia

Cited by 3 publications

References 10 publications

Acneiform Eruption Caused By Varenicline Tartrate: A Case Report

Acneiform Eruption Caused By Varenicline Tartrate: A Case Report

Varenicline‐induced acute generalized exanthematous pustulosis confirmed by patch testing

Fatality following a suicidal overdose with varenicline

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