Variability in aphasia following subcortical hemorrhagic lesion

Krishnan, Gopee; Tiwari, Shivani; Pai, Anand; Rao, Surya N.

doi:10.5214/ans.0972.7531.190404

Cited by 13 publications

(4 citation statements)

References 7 publications

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“…Aphasia was found more common in subjects with hemorrhagic stroke than ischemic stroke (22.1% vs. 21.6%). This is in accordance with a previous study by Krishnan et al (2012) which states that aphasia appears in 8 of 12 hemorrhagic stroke patients. 40 There are different types of aphasia that can occur in stroke patients.…”

Section: Discussionsupporting

confidence: 94%

“…This is in accordance with a previous study by Krishnan et al (2012) which states that aphasia appears in 8 of 12 hemorrhagic stroke patients. 40 There are different types of aphasia that can occur in stroke patients. Broca aphasia (33.3%), global aphasia (29.2%) and anomic aphasia (20.8%) are the most commonly found type of aphasia in stroke patients.…”

Section: Discussionsupporting

confidence: 94%

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Clinical Symptoms and Risk Factors Comparison of Ischemic and Hemorrhagic Stroke

Sanyasi¹,

Pinzon²

2018

JKKI

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Backround: It is very important to know and detect various stroke symptoms because stroke is an emergency condition. Lack of knowledge about stroke symptoms leads to delay on stroke treatment. Objective: The aim of this study is to compare clinical symptoms and risk factors between ischemic and hemorrhagic stroke. Methods: This study was a case control study. The subjects in this study were ischemic and hemorrhagic stroke patients. Subjects' data were recorded in electronic stroke registry at Bethesda Hospital, Yogyakarta. Results: The most common clinical symptoms in both groups were limb weakness (76.4% vs 71.4%), whereas the rarest was face drooping (2% vs 3.6%). Hypertension was the most common risk factor in both group (48% vs 71.4%), whereas atrial fibrillation was the rarest. This study did not find the specific correlation between any clinical symptoms to ischemic stroke incidence, however, decrease a level of consciousness was significant to hemorrhagic stroke incidence (OR: 2.738, 95% CI: 1.503-4.990, p: 0.001). Previous stroke (OR: 2.413, 95% CI: 1.314-4.433, p: 0.005) and dyslipidemia (OR: 4.862, 95% CI: 2.613-9.045, p: 0.000) were significant increasing risk of ischemic stroke. Hypertension was only the significant increasing risk of hemorrhagic stroke (OR: 3.680, 95% CI: 2.086-6.492, p: 0.000). Conclusion: Decrease level of consciousness has a significant correlation to hemorrhagic stroke incidence, but there is no specific symptom correlate to ischemic stroke incidence. Previous stroke and dyslipidemia are significant risk factors for ischemic stroke, whereas hypertension is the only significant risk factor for hemorrhagic stroke.Latar Belakang: Sangat penting untuk mengetahui dan mendeteksi gejala stroke dengan segera karena penanganan stroke berpacu dengan waktu. Kurangnya pengetahuan mengenai gejala stroke akan mengakibatkan keterlambatan dalam penanganan stroke. Tujuan Penelitian: Penelitian ini bertujuan untuk mengetahui perbandingan gejala klinis dan faktor risiko pada pasien stroke iskemik dan stroke hemoragik. Metode: Penelitian ini menggunakan desain penelitian kasus kontrol. Subjek dalam penelitian ini adalah pasien stroke iskemik dan stroke hemoragik yang tergister elekronik di Rumah Sakit Bethesda, Yogyakarta. Hasil: Gejala klinis yang paling sering muncul pada kedua grup adalah kelemahan anggota gerak (76.4% vs 71.4%), sedangkan gejala klinis yang paling jarang adalah wajah perot (2% vs 3.6%). Hipertensi merupakan faktor risiko stroke yang paling sering dijumpai pada kedua grup (48% vs 71.4%), sedangkan atrial fibrilasi paling jarang dijumpai. Penelitian ini tidak menemukan adanya gejala khusus yang

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 94%

Clinical Symptoms and Risk Factors Comparison of Ischemic and Hemorrhagic Stroke

Sanyasi¹,

Pinzon²

2018

JKKI

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“…Second, using VBM, we confirmed the location and extent of atrophy in each time point, which enabled us to move beyond the neural uncertainty of neuropsychological studies based solely on clinical evidence. Third, by employing a longitudinal design focused on a progressive, single-subject atrophy model, we circumvented confounds related to within-sample heterogeneity in multi-participant studies on language disorders ( Nespoulous, 2000 ; Krishnan et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Progressive Compromise of Nouns and Action Verbs in Posterior Cortical Atrophy

et al. 2018

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Processing of nouns and action verbs can be differentially compromised following lesions to posterior and anterior/motor brain regions, respectively. However, little is known about how these deficits progress in the course of neurodegeneration. To address this issue, we assessed productive lexical skills in a patient with posterior cortical atrophy (PCA) at two different stages of his pathology. On both occasions, he underwent a structural brain imaging protocol and completed semantic fluency tasks requiring retrieval of animals (nouns) and actions (verbs). Imaging results were compared with those of controls via voxel-based morphometry (VBM), whereas fluency performance was compared to age-matched norms through Crawford’s t-tests. In the first assessment, the patient exhibited atrophy of more posterior regions supporting multimodal semantics (medial temporal and lingual gyri), together with a selective deficit in noun fluency. Then, by the second assessment, the patient’s atrophy had progressed mainly toward fronto-motor regions (rolandic operculum, inferior and superior frontal gyri) and subcortical motor hubs (cerebellum, thalamus), and his fluency impairments had extended to action verbs. These results offer unprecedented evidence of the specificity of the pathways related to noun and action-verb impairments in the course of neurodegeneration, highlighting the latter’s critical dependence on damage to regions supporting motor functions, as opposed to multimodal semantic processes.

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“…The rate of improvement estimated at 1 year was the highest in the comprehension aspect (70%), followed by the repetition aspect (50%). Krishnan et al [29] studied 12 first-ever hemorrhagic stroke-aphasic subjects, and all participants with non-global aphasia showed preserved comprehension skills. Those with initial global aphasia exhibited recovery of comprehension skills, thus evolving to Broca's aphasia at the follow-up evaluation.…”

Section: Discussionmentioning

confidence: 99%

The Prognosis and Recovery of Aphasia Related to Stroke Lesion

et al. 2016

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ObjectiveTo investigate the effects of specific brain lesions on prognosis and recovery of post-stroke aphasia, and to assess the characteristic pattern of recovery.MethodsTotal of 15 subjects with first-ever, left hemisphere stroke, who were right handed, and who completed language assessment using the Korean version of the Western Aphasia Battery (K-WAB) at least twice during the subacute and chronic stages of stroke, were included. The brain lesions of the participants were evaluated using MRI-cron, SPM8, and Talairach Daemon software.ResultsSubtraction of the lesion overlap map of the participants who showed more than 30% improvement in the aphasia quotient (AQ) by the time of their chronic stage (n=9) from the lesion overlap map of those who did not show more than 30% improvement in the AQ (n=6) revealed a strong relationship with Broca's area, inferior prefrontal gyrus, premotor cortex, and a less strong relationship with Wernicke's area and superior and middle temporal gyri. The culprit lesion related to poor prognosis, after grouping the subjects according to their AQ score in the chronic stage (a cut score of 50), revealed a strong relationship with Broca's area, superior temporal gyrus, and a less strong relationship with Wernicke's area, prefrontal cortex, and inferior frontal gyrus.ConclusionBrain lesions in the Broca's area, inferior prefrontal gyrus, and premotor cortex may be related to slow recovery of aphasia in patients with left hemisphere stroke. Furthermore, involvement of Broca's area and superior temporal gyrus may be associated with poor prognosis of post-stroke aphasia.

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Variability in aphasia following subcortical hemorrhagic lesion

Cited by 13 publications

References 7 publications

Clinical Symptoms and Risk Factors Comparison of Ischemic and Hemorrhagic Stroke

Clinical Symptoms and Risk Factors Comparison of Ischemic and Hemorrhagic Stroke

Progressive Compromise of Nouns and Action Verbs in Posterior Cortical Atrophy

The Prognosis and Recovery of Aphasia Related to Stroke Lesion

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