Variability in clinically measured photopic oscillatory potentials

Kothe, Angela C.; Lovasik, John V.; Coupland, Stuart G.

doi:10.1007/bf00152765

Cited by 15 publications

(7 citation statements)

References 25 publications

(25 reference statements)

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“…A similar study was reported by Kothe et al [11], but all of the results were only from light adaptation in the time domain. They found that the amplitudes of five recordable light-adapted wavelets exhibited considerable intrasubject and intersubject variability.…”

Section: Discussionsupporting

confidence: 66%

“…It means that there is more variation in the dark-adapted OPs. The implicit time of each wavelet of the OPs showed less variation and [15] and Kothe et al [11].…”

Section: Discussionmentioning

confidence: 99%

“…There has been a great deal of disagreement regarding the measurement of the OPs [1,8,9,10,11]. The OPs are often measured by the caliper square method.…”

Section: Introductionmentioning

confidence: 99%

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Measurement of the oscillatory potentials of the electroretinogram in the domains of frequency and time

Li¹,

Yuan²

1990

Doc Ophthalmol

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The dark-adapted and light-adapted electroretinograms of 13 subjects with 23 normal eyes were analyzed by means of Fourier spectrum. The oscillatory potentials in the time domain were filtered out from the electroretinogram after a corresponding bandpass was given in the frequency domain. The coefficient of variation of total power, dominant power and dominant frequency of the isolated oscillatory potentials in the frequency domain, summed amplitudes and area of the isolated oscillatory potentials, each amplitude and implicit time of the first four major oscillatory potential wavelets in the time domain were compared. The implicit time showed the smallest coefficient of variation; summed amplitudes of OP1 to OP4 showed smaller coefficients of variation than those of the area, the amplitude of each oscillatory potential wavelet, dominant frequency and dominant and total power. The coefficient of variation of these measurement parameters in light-adapted electroretinograms was smaller than those in dark-adapted electroretinograms.

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Section: Discussionsupporting

confidence: 66%

“…It means that there is more variation in the dark-adapted OPs. The implicit time of each wavelet of the OPs showed less variation and [15] and Kothe et al [11].…”

Section: Discussionmentioning

confidence: 99%

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Measurement of the oscillatory potentials of the electroretinogram in the domains of frequency and time

Li¹,

Yuan²

1990

Doc Ophthalmol

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“…Kothe et al [11] and Yonemura and Kawaski [12] suggested that the OP implicit time has a smaller intersubject and intrasubject variability and is a more appropriate measurement in clinical neurophysiology. The implicit times of OP1 and OP2 were not significantly different with different background illumination in the present study, but OP3 and OP4 were significantly greater with the stronger background illumination (BG 2 and BG 3).…”

Section: Discussionmentioning

confidence: 99%

The influence of adaptation on the oscillatory potentials of the human electroretinogram

Li¹,

Yuan²,

Hong³

et al. 1991

Doc Ophthalmol

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The influence of adaptation on the oscillatory potentials of the human electroretinogram was studied in the domains of frequency and time. The amplitude of OP1 to OP4, the summed amplitude of OP1 to OP4, as well as the area, decreased from dark adaptation to light adaptation. With increasing intensities of background illumination, they increased slightly and appeared to decrease with the strongest background illumination. The implicit time of oscillatory potentials 3 and 4 increased with stronger background illumination and decreased with the strongest background illumination. The results of the dominant frequency and the total power of the OPs correspond to the results in the time domain. The dominant power decreased from dark adaptation into light adaptation and did not show any systematic changes with increasing intensity of background illumination.

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“…The ususal method of analyzing OPs is to examine the amplitudes and latencies (implicit time) of corresponding peaks. Although a great effort has been made to overcome the problems concerning the sources of interindividual variability, it has recently been emphasized that amplitude values in particular vary greatly among subjects even in strictly controlled conditions (Kothe et al 1989).…”

mentioning

confidence: 99%

Effect of pharmacologically induced mydriasis on the normal variability of retinal oscillatory potentials in man

Polo

Summa

Perlini

et al. 1995

Acta Ophthalmologica Scandinavica

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In this study we describe certain aspects of normal variability of oscillatory potentials, with particular reference to interaction between pupil size and stimulus intensity. The mean latencies of the earlier oscillatory potentials, O1 and O2, were significantly shorter when adopting the dilated pupil condition than when stimulating with a normal pupil. This occurred at various light intensities, although the difference was more significant at the highest intensity. O1 and O2 latencies became significantly longer as the stimulus intensity was progressively reduced. The latencies of the later components O3 and O4 were unaffected. The O1 and O2 amplitudes were not influenced by pupil size, but a significant reduction occurred with the progressive decrease in stimulus intensity. The later components O3 and O4 are greatly reduced in amplitude after pupil dilatation using higher stimulus intensities; the O4 potential may even disappear in 10% of the cases. These data provide further support for the existence of two distinct behavior patterns for earlier and later oscillatory potentials. Although light adaptation may affect oscillatory potentials, we suggest that in our experimental conditions, oscillatory potential changes may occur as a result of the activity of the neural modulating system, not only as a result of photoreceptor interaction.

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Variability in clinically measured photopic oscillatory potentials

Cited by 15 publications

References 25 publications

Measurement of the oscillatory potentials of the electroretinogram in the domains of frequency and time

Measurement of the oscillatory potentials of the electroretinogram in the domains of frequency and time

The influence of adaptation on the oscillatory potentials of the human electroretinogram

Effect of pharmacologically induced mydriasis on the normal variability of retinal oscillatory potentials in man

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