Variability in flavonol content of grapes cultivated in two Mediterranean islands (Sardinia and Corsica)

Ledda, Salvatore; Sanna, Giovanna; Manca, G; Franco, Mario Andrea; Porcu, Arianna

doi:10.1016/j.jfca.2009.05.006

Cited by 18 publications

(13 citation statements)

References 23 publications

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“…In addition to the Bianchetta Trevigiana (Lomolino et al, 2010) and Monastrell (Mulero et al, 2010), eight autochthonous varieties from Sardinia and Corsica are examined to elucidate the influences of variety versus geography on their composition (Ledda et al, 2010). They show that the flavonol profile of Vermentino is strongly correlated with variety rather than with geographical origin.…”

Section: Special Issue Of Jfc On Horticulture Biodiversity and Nutrimentioning

confidence: 99%

Horticulture, biodiversity and nutrition

Lutaladio¹,

Burlingame²,

Crews³

2010

Journal of Food Composition and Analysis

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Section: Special Issue Of Jfc On Horticulture Biodiversity and Nutrimentioning

confidence: 99%

Horticulture, biodiversity and nutrition

Lutaladio¹,

Burlingame²,

Crews³

2010

Journal of Food Composition and Analysis

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“…Myricetin (3,3 ,4 ,5,5 ,7-hexahydroxyflavone) is one of the most commonly found naturally occurring flavanones ( Figure 1), and is predominantly but not exclusively found in berries, tea, vegetables, and herbs [18]. Myricetin is found in abundance in red wine and grapes, with several varieties of grape containing as much as 24 mg of myricetin per kilogram of fresh weight [19,20]. It was first discovered by Perkin and Hummel from the bark of Myrica nagi in 1896.…”

Section: Introductionmentioning

confidence: 99%

Myricetin Abrogates Cisplatin-Induced Oxidative Stress, Inflammatory Response, and Goblet Cell Disintegration in Colon of Wistar Rats

Rehman

Rather

2019

Plants

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Cisplatin [cis-diamminedichloroplatinum II] is an extensively prescribed drug in cancer chemotherapy; it is also useful for the treatment of diverse types of malignancies. Conversely, cisplatin is associated with a range of side effects such as nephrotoxicity, hepatotoxicity, gastrointestinal toxicity, and so on. Myricetin (3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4chromenone) is a very common natural flavonoid found in fruits, tea, and plants. It has been found to have high-value pharmacological properties and strong health benefits. To examine the role of myricetin in colon toxicity induced by cisplatin, we conducted a concurrent prophylactic study in experimental animals that were treated orally with myricetin for 14 days at two doses—25 and 50 mg/kg of body weight. On the 14th day, a single intraperitoneal injection of cisplatin (7.5 mg/kg body weight) was administered in all groups except control. The effects of myricetin in cisplatin-induced toxicity in the colon were assessed in terms of antioxidant status, phase-II detoxification enzymes, the level of inflammatory markers, and goblet cell disintegration. Myricetin was found to restore the level of all the antioxidant enzymes analyzed in the study. In addition, the compound ameliorated cisplatin-induced lipid peroxidation, increase in xanthine oxidase activity, and phase-II detoxifying enzyme activity. Myricetin also attenuated deteriorative effects induced by cisplatin by regulating the level of molecular markers of inflammation (NF-κB, Nrf-2, IL-6, and TNF-α), restoring Nrf-2 levels, and controlling goblet cell disintegration. The current study reinforces the conclusion that myricetin exerts protection in colon toxicity via up-regulation of inflammatory markers, improving anti-oxidant status, and protecting tissue damage.

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“…In addition to beneficial health effects, flavonols have been identified as good biomarkers for chemotaxonomic classification of sea buckthorn (Chen et al ., ) and grapes (Ledda et al ., ), as well as for identification and origin of grape cultivars (Castillo‐Muñoz et al ., ).…”

Section: Introductionmentioning

confidence: 99%