Variability in the resistance of the Nigerian West African Dwarf goat to abbreviated escalating trickle and challenge infections with Haemonchus contortus

Fakae, B.B.; Musongong, G.A.; Chiejina, S.N.; Behnke, Jerzy M.; Ngongeh, Lucas Atehmengo; Wakelin, D.

doi:10.1016/j.vetpar.2004.02.005

Cited by 23 publications

(11 citation statements)

References 26 publications

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“…Our data do not support the generally held view about the high susceptibility of goats to GI nematodes and especially to H. contortus , and their inability to control the pathophysiological consequencies of these infections. On the contrary, both WAD goat ecotypes appear to be naturally endowed with unusually strong resistance and resilience to their native strains of GI nematodes but particularly H. contortus the only species to have been studied experimentally thus far [9,32,33]. …”

Section: Introductionmentioning

confidence: 99%

“…Our laboratory studies employed a variety of infection protocols in 7-9 month old kids, which included single pulse infections ranging from 3000 to 6000 L3 [9,32], trickle and rapidly escalating, immunising infections, followed eight weeks later by chemical abbreviation of infections and, in some animals, challenge with 4000-6000 L3 [33,36]. The results consistently showed extremely low worm establishment and recovery during the prepatent and patent phases of infections, 14-18 and 18-110 days post infection (pi), respectively.…”

Section: Introductionmentioning

confidence: 99%

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The unique resistance and resilience of the Nigerian West African Dwarf goat to gastrointestinal nematode infections

Chiejina

Behnke

2011

Parasites Vectors

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BackgroundWest African Dwarf (WAD) goats serve an important role in the rural village economy of West Africa, especially among small-holder livestock owners. They have been shown to be trypanotolerant and to resist infections with Haemonchus contortus more effectively than any other known breed of goat.MethodsIn this paper we review what is known about the origins of this goat breed, explain its economic importance in rural West Africa and review the current status of our knowledge about its ability to resist parasitic infections.ConclusionsWe suggest that its unique capacity to show both trypanotolerance and resistance to gastrointestinal (GI) nematode infections is immunologically based and genetically endowed, and that knowledge of the underlying genes could be exploited to improve the capacity of more productive wool and milk producing, but GI nematode susceptible, breeds of goats to resist infection, without recourse to anthelmintics. Either conventional breeding allowing introgression of resistance alleles into susceptible breeds, or transgenesis could be exploited for this purpose. Appropriate legal protection of the resistance alleles of WAD goats might provide a much needed source of revenue for the countries in West Africa where the WAD goats exist and where currently living standards among rural populations are among the lowest in the world.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The unique resistance and resilience of the Nigerian West African Dwarf goat to gastrointestinal nematode infections

Chiejina

Behnke

2011

Parasites Vectors

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“…Phenotypic parameters i.e. FEC, PCV, worm burden, infection establishment rate, total protein, serum albumin level and live weight gain/reduction evaluated in the study breeds of present report have also been reported elsewhere (Pralomkarn et al, 1997;Fakae et al, 2004;Baber et al, 2015). The phenotypic parameters have been used to assess the response of experimental animals against challenged infection with H. contortus to determine the comparative resistance/resilience to H. contortus in Teddy and Beetal goat breeds of Pakistan.…”

Section: Discussionmentioning

confidence: 89%

“…Selection of parasite resistant breeds is an alternate option for control of GI nematodes (Fakae et al, 2004). Further, it will be helpful in identifying genetic potential of breed response towards GI nematodes which can help overcome problem of anthelmintic resistance and having an overall better growth and performance (Baker et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Phenotypic Marker Based Evaluation of Resistance to Haemonchus contortus in Teddy and Beetal Goat Breeds of Punjab, Pakistan

Shamim¹,

Sajid²,

Khan³

et al. 2016

IJAB

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“…This was in agreement with Rajguru et al (2002) who reported a significant decrease in the PCV in goats parasitised with H. contortus. Lower PCV values for animals suffering from haemonchosis have been reported (Ejlertsen et al 2006;Fakae et al 2004;Vanimisetti et al 2004;Notter et al 2003). Table 6 shows the least square means for postinfection TSP by coat colour type.…”

Section: Association Of Coat Colour Types and Tolerance Traitsmentioning

confidence: 92%

Preliminary association of coat colour types and tolerance toHaemonchus contortusinfection in West African Dwarf sheep

Sanusi

Peters

Sonibare

et al. 2012

Journal of Applied Animal Research

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Reduction in livestock productivity from internal parasites remains a major problem including the roundworm Haemonchus contortus. Treatment is rather expensive in most resource poor regions of the world, and the use of genetically resistant genotypes have been advocated. Our preliminary study investigated the association of coat colour types and tolerance to H. contortus infection in West African Dwarf (WAD) sheep. Twenty-four WAD sheep (12 males and 12 females) representing five coat colour types were orally dosed with 1000 H. contortus third-stage infective larvae, and data were collected over a 3-week period on initial and post-infection body weight (IBW and PIBW), packed cell volume (PCV), total serum proteins (TSP), albumin (ALB), globulin (GLB) and faecal egg counts (FEC). Coat colour was significantly associated with tolerance to H. contortus infection (p B0.05). Brown mouflon (A m abbSs) sheep showed the highest mean PIBW, PCV and GLB (15.1691.76 kg, 30.6793.53% and 31.1790.54 g/dl), respectively, while brown sheep with extensive white markings (aabbss) had the highest mean TSP and ALB value (73.4092.02 g/dl and 44.4790.49 g/dl), respectively. Badger face (A bf aB-S-) sheep had the least mean values of PIBW, PCV, TSP, ALB, GLB and the highest FEC. There were no significant associations with sex and its interactions with coat colour on post-infection performances of WAD sheep in this study. Our results suggest that brown sheep can tolerate H. contortus infection better than other coat colour types, which may be due to the linkage between coat colour and resistance loci, linkage disequilibrium effects or resulting from pleiotropic effects deserving further study.

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Variability in the resistance of the Nigerian West African Dwarf goat to abbreviated escalating trickle and challenge infections with Haemonchus contortus

Cited by 23 publications

References 26 publications

The unique resistance and resilience of the Nigerian West African Dwarf goat to gastrointestinal nematode infections

The unique resistance and resilience of the Nigerian West African Dwarf goat to gastrointestinal nematode infections

Phenotypic Marker Based Evaluation of Resistance to Haemonchus contortus in Teddy and Beetal Goat Breeds of Punjab, Pakistan

Preliminary association of coat colour types and tolerance toHaemonchus contortusinfection in West African Dwarf sheep

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