Variability of contribution of vitamin D receptor gene polymorphisms to outcome of HLA-matched sibling allogeneic bone marrow transplantation

Kamel, Azza M.; Elfishawi, Sally; Rasekh, Eman O; Radwan, Eman R.; Zeidan, Ashraf; El-Said, Abeer; Zaky, Amen H.; Abdelfattah, Mostafa Galal; Refaat, Ahmed; Abdelfattah, Raafat

doi:10.1080/10428194.2018.1459608

Cited by 4 publications

(3 citation statements)

References 29 publications

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“…The association of VDR gene polymorphisms with major clinical outcomes following HSCT has been investigated in different studies with inconclusive results (116,143,(146)(147)(148)(149)(150). Therefore, further research in this field is warranted with larger study samples, including more recipients of different donor types (unrelated, haploidentical).…”

Section: Vdr As Biomarker In Hsctmentioning

confidence: 99%

Insights Into the Role of Vitamin D as a Biomarker in Stem Cell Transplantation

et al. 2020

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Vitamin D was discovered 100 years ago and since then multiple studies have consistently proved its effect on bone health and mineral metabolism. Further research has also explored its so-called "non-classical" biological effects, encompassing immune regulation and control of cell proliferation and differentiation. Vitamin D downregulates pro-inflammatory immune cells and subsequently their cytokine production, while enhancing the anti-inflammatory subsets, thus mediating inflammation and fostering a more tolerogenic environment. Its biological action is exerted through the vitamin D receptor, a nuclear receptor that mediates gene transcription and is expressed in most cells from the innate and adaptive immunity. Owing to its immune-modulatory properties, its role in cancer pathophysiology, hematology disorders and stem cell transplantation has also been investigated. Vitamin D deficiency causes immune imbalance and cytokine dysregulation, contributing to some autoimmune diseases. In the hematopoietic stem cell transplant setting this could lead to complications such as acute and chronic graft-versus-host disease, ultimately impacting transplant outcomes. Other factors have also been linked to this, including specific polymorphisms of the vitamin D receptor in both stem cell donors and recipients. Nevertheless, studies thus far have shown conflicting results and the use of vitamin D or its receptor as biomarkers has not been validated yet, therefore there are no evidence-based consensus guidelines to guide clinicians in their day-today practice. To gain more insight in this topic, we have reviewed the existent literature and gathered the current evidence. This is an overview of the role of serum vitamin D and its receptor as biomarkers for clinical outcomes in patients undergoing hematopoietic stem cell transplantation. Further prospective studies with larger cohorts are warranted to validate the viability of using serum vitamin D, and its receptor, as biomarkers in potential stem cell donors and patients, to identify those at risk of post-transplant complications and enable early therapeutic interventions.

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Section: Vdr As Biomarker In Hsctmentioning

confidence: 99%

Insights Into the Role of Vitamin D as a Biomarker in Stem Cell Transplantation

et al. 2020

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“…Interestingly, the results of these studies are quite variable. Some studies suggest roles for various polymorphisms in GVHD when present in the recipient only (80–82), some studies suggest a role for VDR genotype in both the donor and recipient (83), while another more recent study found no significant association between GVHD and VDR polymorphisms in the donor nor recipient (84). Taken together, these results suggest that in some instances the a allele of VDR may play a role in aGVHD risk when present in recipients of HSCT.…”

Section: Effects Of Vitamin D On Gvhdmentioning

confidence: 99%

“…Taken together, these results suggest that in some instances the a allele of VDR may play a role in aGVHD risk when present in recipients of HSCT. However, not all studies have found such an association and the results may vary between different populations (84). One complicating factor of these studies was that the vitamin D status of the individuals studied was often unknown.…”

Section: Effects Of Vitamin D On Gvhdmentioning

confidence: 99%

The Role of Micronutrients in Graft-VS.-Host Disease: Immunomodulatory Effects of Vitamins A and D

Chen

Mayne

2018

Front. Immunol.

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Graft-vs.-host disease (GVHD) remains a major obstacle to the success of allogeneic hematopoietic stem cell transplantation (HSCT). GVHD occurs because donor T cells in the allograft recognize the genetically disparate host as foreign and attack the transplant recipient's tissues. While genetic incompatibility between donor and recipient is the primary determinant for the extent of alloimmune response, GVHD incidence and severity are also influenced by non-genetic factors. Recent advances in immunology establish that environmental factors, including dietary micronutrients, contribute significantly to modulating various immune responses and may influence the susceptibility to autoimmune and inflammatory diseases of experimental animals and humans. Emerging clinical and preclinical evidence indicates that certain micronutrients may participate in regulating GVHD risk after allogeneic HSCT. In this review, we summarize recent advances in our understanding with respect to the potential role of micronutrients in the pathogenesis of acute and chronic GVHD, focusing on vitamins A and D.

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