Variability of Genetic Alterations in Different Sites of Head and Neck Cancer

Rodrigo, Juan P.; Suárez, Carlos; González, Marı́a Victoria; Lazo, Pedro S.; Ramos, Sofı́a; Coto, Eliécer; Alvarez, Ignacio; Garcı́a, Luis; Martínez, José Antonio Cernuda

doi:10.1097/00005537-200107000-00029

Cited by 40 publications

(30 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Given the physiological functions of HIF-1a, differences in the therapeutic modality (surgery or radiotherapy) [25,34] may explain those discrepancies as hypoxia notably influences the response to radiotherapy but probably not to surgery. On the other hand, most of the previous studies have been performed in groups of patients with HNSCC from different locations, which are known to have different disease course and prognosis, and carry distinct genetic alterations [35]. These limitations could make the HIF-1a studies in HNSCC susceptible to biases.…”

Section: Discussionmentioning

confidence: 99%

The relation between hypoxia‐inducible factor (HIF)‐1alpha expression with p53 expression and outcome in surgically treated supraglottic laryngeal cancer

Cabanillas

Rodrigo

Secades

et al. 2009

Journal of Surgical Oncology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

The relation between hypoxia‐inducible factor (HIF)‐1alpha expression with p53 expression and outcome in surgically treated supraglottic laryngeal cancer

Cabanillas

Rodrigo

Secades

et al. 2009

Journal of Surgical Oncology

View full text Add to dashboard Cite

show abstract

“…However, the majority of those studies were flawed, because they included heterogeneous groups of patients, various histologies, small numbers of patients, short follow-up, or varying treatment techniques (surgical approach, radiotherapy, chemoradiotherapy). 7,[11][12][13][14][15] Hence, it is not surprising that the results have been inconclusive. Nevertheless, the immunohistochemical determination of p53, in the primary tumor or in its lymph node metastases, continues to be an attractive tool in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

“…This heterogeneity introduces a bias for a correct interpretation of their results, because it is recognized widely that some of the genetic alterations implicated in the development of HNSCC do not appear to be distributed equally among the different locations of this area. 3,6,7 In an attempt to shed more light on this subject, we examined samples from 107 patients with squamous cell carcinomas of a single site, the supraglottic larynx, for p53 expression using immunohistochemical techniques. We also analyzed p53 expression in 46 paired lymph node metastases.…”

mentioning

confidence: 99%

P53 expression in squamous cell carcinomas of the supraglottic larynx and its lymph node metastases

Cabanillas

Rodrigo

Astudillo

et al. 2007

Cancer

View full text Add to dashboard Cite

BACKGROUND.Although p53 overexpression is frequent in head and neck squamous cell carcinomas (HNSCCs), controversy remains regarding the prognostic significance of that overexpression. The objective of this study was to investigate the expression pattern and prognostic significance of p53 expression in HNSCC of the same location, treated in the same way, and with long‐term follow‐up.METHODS.P53 expression was determined by immunohistochemistry in paraffin‐embedded tissue specimens from 107 consecutive patients (107 primary squamous cell carcinomas of the supraglottic larynx and 46 matched lymph node metastases). All patients underwent surgical resection and bilateral neck dissection.RESULTS.A strong correlation was observed between p53 expression in the primary tumor and in the matched lymph node metastases (P = .0001). P53 overexpression in the lymph nodes was an independent predictor of regional recurrence (P = .027). Likewise, expression of p53 in the lymph nodes correlated significantly with disease‐specific survival (P = .018). Five years after treatment, 70% of patients with p53‐negative, metastatic lymph nodes remained alive, whereas only 30% of patients with p53‐positive lymph nodes remained alive. In multivariate analysis, lymph node status and p53 expression in the lymph nodes remained associated with survival.CONCLUSIONS.The current data suggested that, although p53 overexpression is common in supraglottic carcinomas, its expression in the primary tumor is of limited clinical significance. However, the results supported the role of p53 in the lymph node metastases as an independent predictor of regional failure and a poor prognosis in patients with HNSCC. A prospective trial is indicated to validate these findings. Cancer 2007. © 2007 American Cancer Society.

show abstract

“…A number of studies have identified molecular distinctions among HNSCCs of varying anatomic origin (Rodrigo et al 2001;Belbin et al 2008;Kokko et al 2011;Lleras et al 2013). CD44 expression, for instance, was found to be predictive of 5-yr survival in primary pharyngeal and laryngeal tumors, but not in tumors arising in the oral cavity (Kokko et al 2011).…”

Section: A B Cmentioning

confidence: 99%

Transcriptome sequencing uncovers novel long noncoding and small nucleolar RNAs dysregulated in head and neck squamous cell carcinoma

Zou

Honda

et al. 2015

RNA

View full text Add to dashboard Cite

Head and neck squamous cell carcinoma persists as one of the most common and deadly malignancies, with early detection and effective treatment still posing formidable challenges. To expand our currently sparse knowledge of the noncoding alterations involved in the disease and identify potential biomarkers and therapeutic targets, we globally profiled the dysregulation of small nucleolar and long noncoding RNAs in head and neck tumors. Using next-generation RNA-sequencing data from 40 pairs of tumor and matched normal tissues, we found 2808 long noncoding RNA (lncRNA) transcripts significantly differentially expressed by a fold change magnitude ≥2. Meanwhile, RNA-sequencing analysis of 31 tumor-normal pairs yielded 33 significantly dysregulated small nucleolar RNAs (snoRNA). In particular, we identified two dramatically downregulated lncRNAs and one down-regulated snoRNA whose expression levels correlated significantly with overall patient survival, suggesting their functional significance and clinical relevance in head and neck cancer pathogenesis. We confirmed the dysregulation of these noncoding RNAs in head and neck cancer cell lines derived from different anatomic sites, and determined that ectopic expression of the two lncRNAs inhibited key EMT and stem cell genes and reduced cellular proliferation and migration. As a whole, noncoding RNAs are pervasively dysregulated in head and squamous cell carcinoma. The precise molecular roles of the three transcripts identified warrants further characterization, but our data suggest that they are likely to play substantial roles in head and neck cancer pathogenesis and are significantly associated with patient survival.

show abstract

Variability of Genetic Alterations in Different Sites of Head and Neck Cancer

Abstract: These results suggest that cancers originating from different sites in the head and neck may have different tumor biology. Therefore, they should be considered as different entities.

Cited by 40 publications

References 13 publications

The relation between hypoxia‐inducible factor (HIF)‐1alpha expression with p53 expression and outcome in surgically treated supraglottic laryngeal cancer

The relation between hypoxia‐inducible factor (HIF)‐1alpha expression with p53 expression and outcome in surgically treated supraglottic laryngeal cancer

P53 expression in squamous cell carcinomas of the supraglottic larynx and its lymph node metastases

Transcriptome sequencing uncovers novel long noncoding and small nucleolar RNAs dysregulated in head and neck squamous cell carcinoma

Contact Info

Product

Resources

About