2018
DOI: 10.1136/emermed-2018-207929
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Variability of outcome measures in trials of intravenous therapy in acute severe paediatric asthma: a systematic review

Abstract: ObjectiveTo determine the variability of primary and secondary outcomes used in trials of intravenous bronchodilators in children with acute severe paediatric asthma.MethodsSystematic search of MEDLINE, EMBASE, Cochrane CENTRAL and the WHO International Clinical Trials Registry Platform for randomised trials in children (less than18 years) with acute severe paediatric asthma comparing intravenous bronchodilator therapy to another treatment. Initial search was performed on 7 January 2016 with an updated search … Show more

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Cited by 12 publications
(15 citation statements)
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“…Data extraction included authors, year of publication, geographic location, number of patients, primary, secondary, and other outcomes used, and study interventions including dosing and timing of medication administered. The systematic review was prospectively registered in the PROS-PERO database (CRD42017055331), and has recently been published [46]. We identified 35 published papers and four registered study protocols.…”
Section: Systematic Reviewmentioning
confidence: 99%
See 2 more Smart Citations
“…Data extraction included authors, year of publication, geographic location, number of patients, primary, secondary, and other outcomes used, and study interventions including dosing and timing of medication administered. The systematic review was prospectively registered in the PROS-PERO database (CRD42017055331), and has recently been published [46]. We identified 35 published papers and four registered study protocols.…”
Section: Systematic Reviewmentioning
confidence: 99%
“…Other primary outcomes identified included bedside tests of respiratory function (11/56; 20%) and measures of length of stay (9/56; 16%). There were a total of 60 different secondary outcomes; the most common were various measures of length of stay (24/60; 40%) and adverse events (11/60; 18%) [46].…”
Section: Systematic Reviewmentioning
confidence: 99%
See 1 more Smart Citation
“…The systematic review was prospectively registered in the PROSPERO database (CRD42017055331), and has recently been published. 47 We identified 35 published papers and four registered study protocols. Fifty-six primary outcomes were identified, the most common being a clinical asthma score (23/56; 41%).…”
Section: Systematic Reviewmentioning
confidence: 99%
“…There were a total of 60 different secondary outcomes, the most common were various length of stay measures (24/60; 40%) and adverse events (11/60; 18%). 47 Overview of Cochrane Reviews.…”
Section: Systematic Reviewmentioning
confidence: 99%