Immigrants may experience many psychosocial problems when migrating from a home to a host country, including social isolation. Social exclusion is also important among the problems experienced by immigrants. This study aims to determine the factors affecting Afghan immigrants' perceived social exclusion in Türkiye. Accordingly, a cross‐sectional study was conducted on 211 Afghan immigrants (Mage = 30.66, SD = 9), 24% of whom were females. The socio‐demographic information form, social exclusion scale, self‐esteem rating scale, and life satisfaction scale were used to collect data in this study. The findings showed that Turkish language proficiency, the length of residence in Türkiye, working status in Türkiye, life satisfaction, and negative self‐esteem were predictor factors for social exclusion. Considering the results, suggestions to decision‐makers and mental health professionals to reduce the perceived social exclusion of Afghan immigrants are discussed.