Variability of the Paraoxonase Gene (PON1) in Euro- and Afro-Brazilians

Allebrandt, Karla V.; Souza, Ricardo Lehtonen Rodrigues de; Chautard‐Freire‐Maia, Eleidi A.

doi:10.1006/taap.2002.9368

Cited by 41 publications

(34 citation statements)

References 32 publications

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“…The R allele frequency in the East Asian population was 55% in controls and 54% in cases, whereas in the Caucasians, the frequency was 24% in controls and 35% in cases. An earlier study also revealed very distinctive distribution of the allele frequencies of the 192R and the 55M alleles for the Caucasian, Asian and Afro-American populations [50]. In this study, the observed positive association of the 192R allele with stroke susceptibility in the Caucasian population, and the lack of association in the East Asian population suggest that ethnicity could be a potential determinant of the disease risk, owing to the differences in genetic architecture of these two populations.…”

Section: Discussionmentioning

confidence: 61%

Relationship between Paraoxonase 1 (PON1) gene polymorphisms and susceptibility of stroke: a meta-analysis

Banerjee

2010

Eur J Epidemiol

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Genetic variants of paraoxonase 1 (PON1) were implicated in stroke susceptibility in several case-control association studies. However, the studies have reported apparently conflicting results, rendering precise assessment of the disease risk associated with the variants difficult. A meta-analysis was therefore conducted by including the studies that examined the association between two common polymorphisms (L55M and Q192R) in the coding region of PON1 gene and the risk of stroke. Altogether 10 studies on L55M polymorphism and 11 studies on Q192R polymorphism were included in this meta-analysis. The results showed, although there was no significant association of the 55L allele with stroke [random effects OR = 1.09, 95% CI (0.93, 1.27), P = 0.29], the 192R allele conferred significant risk of stroke in the overall study population [random effects OR = 1.25, 95% CI (1.07, 1.46), P = 0.006]. Same pattern of results as both the allele contrasts was obtained for the homozygote contrasts and the dominant, recessive and additive models. Subgroup analyses for stroke type, age of patients and ethnicity revealed no association of the 55L allele with stroke, whereas the association of the 192R allele persisted significantly in the groups comprising ischemic stroke patients, stroke patients with mean age >60 years and Caucasian subjects. But no significant association of this allele with stroke susceptibility was detected in the East Asian population. Therefore, the results of this meta-analysis indicate, the Q192R polymorphism could be an important risk factor for stroke, especially in the Caucasian population.

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Section: Discussionmentioning

confidence: 61%

Relationship between Paraoxonase 1 (PON1) gene polymorphisms and susceptibility of stroke: a meta-analysis

Banerjee

2010

Eur J Epidemiol

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“…More recently there have been many studies investigating the association between PON gene polymorphisms and CAD. Some studies suggest that there is an association, [2][3][4][5][6][7] but others show no association. [8][9][10][11][12] Although some of these controversial results can be explained by factors such as the type of population studied, dietary habits, environmental differences and differences in study design, the answers remain unclear.…”

Section: Introductionmentioning

confidence: 94%

A preliminary study of human paraoxonase and PON 1 L/M55–PON 1 Q/R 192 polymorphisms in Turkish patients with coronary artery disease

Kaman

İlhan

Metin

et al. 2009

Cell Biochemistry & Function

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Paraoxonase 1 (PON 1) is a high-density lipoprotein (HDL)-associated enzyme with antioxidant function protecting low-density lipoprotein (LDL) from oxidation. PON 1 has two amino acid polymorphisms in coding region; L/M 55 and Q/R 192. These polymorphisms modulate paraoxonase activity of the enzyme. PON 1 activity decreases in coronary artery disease (CAD). In the present study, distribution of PON 1 L/M 55 and Q/R 192 polymorphisms and the effect of these polymorphisms on the activities of PON 1, and on the severity of CAD in 277 CAD (+) patient and 92 CAD (-) subjects were examined. PON 1 L/M 55 and Q/R 192 genotypes were determined by PCR, RFLP and agarose gel electrophoresis techniques. Genotype distributions and allele frequencies for PON 1 Q/R 192 polymorphism were not significantly different between controls and CAD (+) patient group (p > 0.05), but in genotype and allele distribution of PON 1 L/M55 polymorphism, there was significantly difference among groups (p < 0.05). Genotype distributions for both polymorphisms were not significantly different between subgroups of single-vessel disease (SVD), double-vessel disease (DVD) and triple-vessel disease (TVD). Serum PON 1 activity was lower in CAD (+) group than in controls and this was also statistically significant (p < 0.001). In both groups, the highest PON activities were detected in LL and RR genotypes. In summary, our results suggest that there is an association between the PON 1 L/M 55 polymorphism of paraoxonase and CAD in Turkish patients but not with PON 1 Q/R 192 polymorphism. However, it is hard to correlate these polymorphisms and severity of CAD.

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“…Abbott et al (14) also revealed that the decreased PON activity was involved in diabetic neuropathy. Some studies suggest that there is an association (23)(24)(25)(26)(27), but others show no association between PON gene polymorphisms and coronary hearth disease (28)(29)(30). Although some of these controversial results can be explained by factors such as the type of population studied, dietary habits, environmental differences and differences in study design, the answers remain unclear (5).…”

Section: Discussionmentioning

confidence: 99%

Serum Paraoxonase Levels and PON1(192) Polymorphism in Type 2 Diabetes Mellitus Patients

Gökçen¹

2013

gmj

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Objective: Paraoxonase-1 (PON1) is an HDL-associated enzyme implicated in the pathogenesis of atherosclerosis by protecting lipoproteins against peroxidation. PON1 has two genetic polymorphisms both due to amino acid substitution, one involving glutamine and arginine at position 192 and the other leucineand methionine at position 55. Our study aimed to compare the effect of PON192 polymorphism and PON1 activity in patients with type 2 diabetes mellitus (T2DM) and non-diabetic controls. Material and Methods: 50 patients with T2DM and 30 non-diabetic controls were included in this study. The PON192 polymorphism was studied by polymerase chain reaction/restriction fragment length polymorphism (PCR/RFLP). Paraoxonase activity was measured by spectrophotometric method. Results: The frequencies of the QQ, QR and RR genotypes were found as 36.5 and 14% in type 2 diabetes patients and 26.67, 46.66, 26.67% in control subjects, respectively. The paraoxonase activity was detected at lower levels in diabetics (102.0 ±38.9) than in control subjects (158.1±63.7). PON1192 RR homozygotes had significantly higher PON activity than QR and QQ genotypes among control and type 2 diabetes patients (p<0.005). Conclusion:In comparing the activities of three genotypes of the control and type 2 diabetic groups; all activities were found significantly lower in diabetics. In conclusion, we suggested that paraoxonase activities are affected by PON1 genetic variability in patients with type 2 diabetes mellitus and controls.

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Variability of the Paraoxonase Gene (PON1) in Euro- and Afro-Brazilians

Cited by 41 publications

References 32 publications

Relationship between Paraoxonase 1 (PON1) gene polymorphisms and susceptibility of stroke: a meta-analysis

Relationship between Paraoxonase 1 (PON1) gene polymorphisms and susceptibility of stroke: a meta-analysis

A preliminary study of human paraoxonase and PON 1 L/M55–PON 1 Q/R 192 polymorphisms in Turkish patients with coronary artery disease

Serum Paraoxonase Levels and PON1(192) Polymorphism in Type 2 Diabetes Mellitus Patients

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