Variability of total thiol compounds, oxidative and nitrosative stress in uncomplicated pregnant women and nonpregnant women

Özkan, Yeşim; Yardım-Akaydin, Sevgi; Erdem, Ahmet; Şimşek, Bolkan

doi:10.1007/s00404-011-2150-0

Cited by 12 publications

(6 citation statements)

References 41 publications

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“…The rise in serum sFlt-1 levels observed in our study as gestation progresses, is consistent with several studies19,39,41. It is likely that this elevation is due to increasing placental ischemia and oxidative stress occurring during pregnancy, indicative of angiogenic restriction, and controlled vascular permeability42, and is corroborated by others39,43,44.…”

Section: Discussionsupporting

confidence: 92%

Circulating soluble fms-like tyrosine kinase-1, soluble endoglin and placental growth factor during pregnancy in normotensive women in KwaZulu-Natal, South Africa

Ogunlola¹,

Reddy²,

Sibiya³

et al. 2019

Afr H. Sci.

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BackgroundBased on the increased pre-eclampsia and HIV antenatal incidence in South Africa, we determined the angiogenic profiles due to its mechanistic link in preeclampsia development, throughout uncomplicated pregnancies in HIV positive and negative women.ObjectiveTo determine the angiogenic profiles throughout uncomplicated pregnancies in HIV positive and HIV negative women. We explored possible correlations between angiogenic serum levels and selected maternal characteristics (HIV status, gestational age, maternal factors, and pregnancy outcomes).MethodThis study was conducted at a primary health care facility in Durban, South Africa. Forty-six pregnant women aged 18–45 years, were enrolled at 10–20, 22–30 and 32–38 weeks' gestation, respectively through convenient sampling. Serum samples were collected and quantitatively evaluated using ELISAs. Clinical and epidemiological data were analysed using STATA (version 14). A probability level of p < 0.05 was considered statistically significant.ResultsOf those enrolled, 28.3% were nulliparous, 82% were HIV positive and none developed pre-eclampsia. Systolic and diastolic blood pressure increased slightly throughout pregnancy. Fluctuating angiogenic and anti-angiogenic levels were demonstrated during pregnancy.ConclusionThis study contributes to the current angiogenic knowledge in normotensive pregnancies, and may assist as a reference range against which these factors may be compared in HIV complicated pregnancies.

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Section: Discussionsupporting

confidence: 92%

Circulating soluble fms-like tyrosine kinase-1, soluble endoglin and placental growth factor during pregnancy in normotensive women in KwaZulu-Natal, South Africa

Ogunlola¹,

Reddy²,

Sibiya³

et al. 2019

Afr H. Sci.

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“…Further, it has been proposed that oxidative stress provokes the release of sFlt-1 to a similar or greater extent than hypoxia [37]. Various longitudinal studies have shown increasing oxidative stress during pregnancy [38], [39], [40]. We have earlier reported a positive association between oxidative stress and sFlt-1 in preeclampsia [8].…”

Section: Discussionmentioning

confidence: 77%

Gestation Dependant Changes in Angiogenic Factors and Their Associations with Fetal Growth Measures in Normotensive Pregnancy

et al. 2013

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BackgroundEarlier studies indicate that altered angiogenesis at birth is associated with poor birth outcome in women with preeclampsia. Now, we hypothesize that the progressive gestation dependant changes in markers of angiogenesis will be more useful to predict birth weight early even in a normotensive pregnancy. This study for the first time examines the association of gestation dependant changes in the levels of maternal angiogenic factors in addition to their levels in cord with birth weight.MethodNinety two pregnant women were followed at three different time points: 16–20 weeks, 26–30 weeks and at delivery during pregnancy. Plasma levels of angiogenic and anti angiogenic factors were determined by commercial enzyme-linked immunosorbent assay (ELISA) kits.ResultsMaternal plasma VEGF levels increased (p<0.01) till the second time point and decreased (p<0.05) up to delivery while plasma sFlt-1 levels increased (p<0.01) at delivery. PlGF levels peaked (p<0.01) at second time point and decreased (p<0.01) at delivery. Cord plasma VEGF levels were higher (p<0.01) and sFlt-1 levels were lower (p<0.01) as compared to maternal values at all time points. Maternal plasma VEGF levels at first time point and PlGF levels at delivery were positively (p<0.05 and p<0.01 respectively), while sFlt-1/PlGF ratio at delivery was negatively associated (p<0.05) with birth weight.ConclusionLevels of pro- and anti-angiogenic factors may be differentially regulated across gestation. Maternal VEGF levels at early gestation (16–20 weeks) may be predictive of birth weight in healthy term pregnancies.

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“…The idea has, nonetheless, been broadly documented by biomedicine. Thus, for instance, it is very well established that pregnant women endure higher serum levels of lipid peroxidation when compared to non-pregnant women (Little et al, 1999;Ozkan et al, 2012), and that this is accompanied by an increase in serum lipids (e.g., Toescu et al, 2002;Sarandöl et al, 2004). We highlighted the importance of assessing the covariance between MDA and triglyceride concentrations to interpret the lipid oxidative damage measurements (Romero-Haro and Alonso-Alvarez, 2014; Pérez-Rodríguez et al, in press).…”

Section: Discussionmentioning

confidence: 94%

Early development conditions and the oxidative cost of social context in adulthood: an experimental study in birds

2015

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Environmental conditions during early life may shape phenotype in adulthood. Early adverse conditions may increase the oxidative stress in adults, which could affect their reproductive output and survival. It has also been hypothesized that the larger the reproductive investment, the higher the oxidative stress. We tested this and the potential influence of early oxidative stress on how individuals respond to a reproductive stimulation. The synthesis of the antioxidant glutathione was inhibited in captive zebra finches (Taeniopygia guttata) during growth. In adulthood, the expression of a carotenoid-based sexual signal, bill redness, increased in both sexes, with females also being heavier than controls. The social context of control and glutathione-inhibited males was then manipulated to stimulate precopulatory reproductive investments. Males were individually caged in front of a female or another male. We predicted that males enduring lower early antioxidant levels and placed close to a female should pay the highest cost of a hypothetical increase in bill redness in terms of oxidative damage. However, early conditions only influenced the male's phenotype via their partners. Males caged with females showed increases in circulating pigment (carotenoid) levels, but only when females endured early low antioxidant values. This was probably related to the higher attractiveness of these females. Nevertheless, the bill redness of males did not differ during the social manipulation. Moreover, males facing females from any early condition group showed lower oxidative damage levels in plasma lipids. This result agrees with some findings in rodents, also in captivity. However, the effect may be due to increased triglyceride levels and body mass in males not facing females, as variation in these traits explained oxidative damage variability. The importance of considering housing conditions and life history when interpreting oxidative stress-related trade-offs is highlighted.

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Variability of total thiol compounds, oxidative and nitrosative stress in uncomplicated pregnant women and nonpregnant women

Abstract: This study provides information about the changes in plasma levels of many variables having important role in pregnancy complication during all trimesters in uncomplicated pregnancy compared with nonpregnant women.

Cited by 12 publications

References 41 publications

Circulating soluble fms-like tyrosine kinase-1, soluble endoglin and placental growth factor during pregnancy in normotensive women in KwaZulu-Natal, South Africa

Circulating soluble fms-like tyrosine kinase-1, soluble endoglin and placental growth factor during pregnancy in normotensive women in KwaZulu-Natal, South Africa

Gestation Dependant Changes in Angiogenic Factors and Their Associations with Fetal Growth Measures in Normotensive Pregnancy

Early development conditions and the oxidative cost of social context in adulthood: an experimental study in birds

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