Variable binding affinities for allergen suggest a ‘selective competition’ among immunoglobulins in atopic and non-atopic humans

Jackola, Duaine R.; Pierson-Mullany, Lisa K.; Liebeler, Carol L.; Blumenthal, Malcolm N.; Rosenberg, Andreas

doi:10.1016/s0161-5890(02)00108-6

Cited by 26 publications

(38 citation statements)

References 24 publications

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“…Allergen-specific IgG production is probably more common than is specific IgE, as has been independently observed by our group [6] and others [4,5]. In particular, allergen-specific IgG1 is elevated among those who are also atopically sensitized to a particular allergen, like ragweed pollen [6] or house dust mite [7].…”

Section: Discussionmentioning

confidence: 54%

“…In particular, allergen-specific IgG1 is elevated among those who are also atopically sensitized to a particular allergen, like ragweed pollen [6] or house dust mite [7]. The production of allergen-specific IgG1 may not be atopic disease associated, but it is associated with immune system humoral response development to antigens known to be atopy-associated.…”

Section: Discussionmentioning

confidence: 99%

“…Aside from disease manifestation, the atopic and nonatopic immune responses may have more in common than are disparate, including vigorous humoral responses to these antigens [6,20]. Before the genes associated with atopic disease can be found, it may be best to first unravel the genetic components involved with immune responses to these unique types of antigens.…”

Section: Discussionmentioning

confidence: 99%

“…Save for specific IgE production, it has been shown that it is equally likely for anyone to mount a T cell-dependent humoral response to allergens involving varying amounts of the IgA and IgG isotype subclasses [4,5]. Of special note, specific IgG1 is elevated among those with atopic sensitization to a particular allergen [6].…”

Section: Introductionmentioning

confidence: 99%

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Search for quantitative trait loci of atopy-associated immune responses using allergen-specific IgG1 as an “endophenotype”

et al. 2007

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Inherited atopic diseases of humans arise from adverse adaptive humoral responses to non-infectious environmental allergens. We have previously reported that allergen-specific IgG1 provides more reliable heritability estimates for responses to allergens than total IgE. Genome scans were done for 91 Caucasian nuclear families with history of atopy for total IgE and IgG1 produced against a common major allergen from house dust mite, Der p 1. Suggestive associations for Der p 1-IgG1 production were found at 7 quantitative trait loci (QTL) (logarithm of the odds, LOD ≥ 1.23; p ≤ 0.009) with QTL-specific heritabilities of 73% -80%. Scans using total IgE found suggestive associations for 12 QTL's (LOD ≥ 1.44; p ≤ 0.004), but QTL-specific heritabilities only in the range of 30% -35%. Allergen-specific IgG1 is a suitable 'endophenotype' to be used in searches for genes associated with atopy-associated humoral immune responses to common aeroallergens.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Search for quantitative trait loci of atopy-associated immune responses using allergen-specific IgG1 as an “endophenotype”

et al. 2007

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“…The intensity of the immune response to allergens is crucial to develop an allergic condition mediated by IgE antibody, or a healthy condition depending on the individual gene susceptibility, environmental pollutants, features of allergens, among others [22][23][24]. Other antibody classes have been analyzed because of this variation of response between allergic and healthy subjects, such as IgA and IgG subclasses [23][24][25].…”

Section: Effector Phasementioning

confidence: 99%

Allergen-Specific Immunotherapy Follow-Up by Measuring Allergen-Specific IgG as an Objective Parameter

Taketomi¹,

Miranda²,

Júnior³

et al. 2017

Immunotherapy - Myths, Reality, Ideas, Future

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The clinical efficacy of the allergen-specific immunotherapy (AIT) has been well-documented using inhalant or hymenoptera-derived allergens in atopic patients with corresponding specific IgE antibodies. AIT is considered as the unique treatment that is capable of modifying the natural course of the allergic disease because it induces a variety of immunological mechanisms, with emphasis in the production of blocking IgG antibodies by IL-10-stimulated B cells due to the generation of Treg, Breg, or even Th2 cells. Thus, the measurement of specific IgG subclasses, particularly IgG4, to the crude extract or more importantly to allergen components, might be a useful and potential tool to follow-up objectively the patients undergoing AIT in addition to clinical parameters. In this chapter, the authors have emphasized a very sensitive and highly specific reverse ELISA, developed by them, to measure IgG subclasses directed to clinically relevant natural allergens that are undoubtedly better when compared to those obtained with recombinant counterparts. Such a technique may produce more authentic results taking into account the IgG subclass binding capacity to a particular allergen and might be a valuable and alternative method for monitoring activation of tolerance-inducing mechanisms in patients under AIT.

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Immunological Approaches for Tolerance Induction in Allergy

Conrad

Renz

Blaser

2011

Vaccines Against Allergies

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Allergy is the consequence of an inappropriate inflammatory immune response generated against harmless environmental antigens. In allergic disorders such as asthma and rhinitis, the Th2 mediated phenotype is a result of loss of peripheral tolerance mechanisms. In cases such as these, approaches such as immunotherapy attempt to treat the underlying cause of allergic disease by restoring tolerance. Immunotherapy initiates many complex mechanisms within the immune system that result in initiation of innate immunity, activation of both cellular and humoral B cell immunity, as well as triggering T regulatory subsets which are major players in the establishment of peripheral tolerance. Though studies clearly demonstrate immunotherapy to be efficacious, research to improve this treatment is ongoing. Investigation of allergenicity versus immunogenicity, native versus modified allergens, and the use of adjuvant and modality of dosing are all current strategies for immunotherapy advancement that will be reviewed in this article.

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Variable binding affinities for allergen suggest a ‘selective competition’ among immunoglobulins in atopic and non-atopic humans

Cited by 26 publications

References 24 publications

Search for quantitative trait loci of atopy-associated immune responses using allergen-specific IgG1 as an “endophenotype”

Search for quantitative trait loci of atopy-associated immune responses using allergen-specific IgG1 as an “endophenotype”

Allergen-Specific Immunotherapy Follow-Up by Measuring Allergen-Specific IgG as an Objective Parameter

Immunological Approaches for Tolerance Induction in Allergy

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