In this paper, a novel global time-varying path planning (GTVP) method is proposed. In the method, real-time paths can be generated based on tunable Bezier curves, which can realize obstacle avoidance of manipulators. First, finite feature points are extracted to represent the obstacle information according to the shape information and position information of the obstacle. Then, the feature points of the obstacle are converted into the feature points of the curve, according to the scale coefficient and the center point of amplification. Furthermore, a Bezier curve representing the motion path at this moment is generated to realize real-time adjustment of the path. In addition, the 5-degree Bezier curve planning method consider the start direction and the end direction is used in the path planning to avoid the situation of abrupt change with oscillation of the trajectory. Finally, the GTVP method is applied to multi-obstacle environment to realize global time-varying dynamic path planning. Through theoretical derivation and simulation, it can be proved that the path planned by the GTVP method can meet the performance requirements of global regulation, real-time change and multi-obstacle avoidance simultaneously.