Variable Genomic and Metabolomic Responses to Varying Doses of Vitamin D Supplementation

Shirvani, Arash; Kalajian, Tyler Arek; Song, Anjeli; Allen, Rachel; Charoenngam, Nipith; Lewanczuk, Richard; Holick, Michael F.

doi:10.21873/anticanres.13982

Cited by 25 publications

(36 citation statements)

References 24 publications

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“…It is important to note that supplementation of vitamin D or raising serum with robust genomic response to vitamin D supplementation exhibited different patterns of serum metabolomic profile compared with those with lower degree of responsiveness [45]. This observation is in line with that of the prior study by Carlberg et al [46] showing robust changes in broad gene expression in about half of the 71 patients with prediabetes who were given daily 3,200 IUs of vitamin D3 for 5 months.…”

Section: Effects Of Vitamin D On the Immune Systemsupporting

confidence: 85%

Vitamin D and Rheumatic Diseases: A Review of Clinical Evidence

Charoenngam

2021

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Vitamin D plays an important role in maintaining healthy mineralized skeleton. It is also consid-ered an immunomodulatory agent that regulate the innate and adaptive immune systems. Multi-ple observational studies have demonstrated the association between low level of serum 25-hydroxyvitamin D [25(OH)D] and presence and severity of several rheumatic diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), spondyloarthropathies and oste-oarthritis (OA). Nevertheless, the specific benefits of vitamin D supplement for treatment and prevention of rheumatic diseases are less accepted as the results from randomized clinical trials are inconsistent, although some conceivable benefits of vitamin D for improvement of disease ac-tivity of RA, SLE and OA have been demonstrated in meta-analyses. It is also possible that some individuals might benefit from vitamin D differently from others since inter-individual difference in responsiveness to vitamin D supplementation has been observed in genomic studies. Although the optimal level of serum 25(OH)D is still debatable, it is advisable it is advisable that patients with rheumatic diseases should maintain serum 25(OH)D level at least 30 ng/mL (75 nmol/L) to prevent osteomalacia, secondary osteoporosis and fracture, and possibly 40 – 60 ng/mL (100 – 150 nmol/L) to achieve maximal benefit from vitamin D for immune health and overall health.

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Section: Effects Of Vitamin D On the Immune Systemsupporting

confidence: 85%

Vitamin D and Rheumatic Diseases: A Review of Clinical Evidence

Charoenngam

2021

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“…This is dramatically illustrated in Figure 5 which shows that 60% of the healthy vitamin D deficient adults who received 10,000 IUs daily for 6 months had a robust response in gene expression compared to the other 40% who had minimum to modest responses even though these subjects raised their blood levels of 25(OH)D in the same range of 60–90 ng/mL (150–225 nmol/L) [ 186 ]. In addition, different patterns of serum metabolomic profile were also observed between the subjects with robust and minimum to modest responses in gene expression [ 186 , 189 ]. It is therefore possible that the effect of vitamin D supplementation on health outcomes at the populational level is diluted due to the possibility that some individuals might benefit from vitamin D differently from others.…”

Section: The Concept Of Individual Responsiveness To Vitamin Dmentioning

confidence: 99%

Immunologic Effects of Vitamin D on Human Health and Disease

2020

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Vitamin D is responsible for regulation of calcium and phosphate metabolism and maintaining a healthy mineralized skeleton. It is also known as an immunomodulatory hormone. Experimental studies have shown that 1,25-dihydroxyvitamin D, the active form of vitamin D, exerts immunologic activities on multiple components of the innate and adaptive immune system as well as endothelial membrane stability. Association between low levels of serum 25-hydroxyvitamin D and increased risk of developing several immune-related diseases and disorders, including psoriasis, type 1 diabetes, multiple sclerosis, rheumatoid arthritis, tuberculosis, sepsis, respiratory infection, and COVID-19, has been observed. Accordingly, a number of clinical trials aiming to determine the efficacy of administration of vitamin D and its metabolites for treatment of these diseases have been conducted with variable outcomes. Interestingly, recent evidence suggests that some individuals might benefit from vitamin D more or less than others as high inter-individual difference in broad gene expression in human peripheral blood mononuclear cells in response to vitamin D supplementation has been observed. Although it is still debatable what level of serum 25-hydroxyvitamin D is optimal, it is advisable to increase vitamin D intake and have sensible sunlight exposure to maintain serum 25-hydroxyvitamin D at least 30 ng/mL (75 nmol/L), and preferably at 40–60 ng/mL (100–150 nmol/L) to achieve the optimal overall health benefits of vitamin D.

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“…At the same time, vitamin D supplementation in insufficient-defined individuals is associated with gene expression. In a 2020 randomized controlled trial, different doses of supplementation, i.e., 600, 2000, and 10,000 IU, and placebo were given to patients with levels of vitamin D of less than 30 ng/mL [24]. After 6 months, there was a dose-dependent increase in serum 25(OH)D and gene expression levels.…”

Section: Mechanism Of Actionmentioning

confidence: 99%

Vitamin D and Its Role in the Lipid Metabolism and the Development of Atherosclerosis

et al. 2021

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Vitamin D, a crucial hormone in the homeostasis and metabolism of calcium bone, has lately been found to produce effects on other physiological and pathological processes genomically and non-genomically, including the cardiovascular system. While lower baseline vitamin D levels have been correlated with atherogenic blood lipid profiles, 25(OH)D supplementation influences the levels of serum lipids in that it lowers the levels of total cholesterol, triglycerides, and LDL-cholesterol and increases the levels of HDL-cholesterol, all of which are known risk factors for cardiovascular disease. Vitamin D is also involved in the development of atherosclerosis at the site of the blood vessels. Deficiency of this vitamin has been found to increase adhesion molecules or endothelial activation and, at the same time, supplementation is linked to the lowering presence of adhesion surrogates. Vitamin D can also influence the vascular tone by increasing endothelial nitric oxide production, as seen in supplementation studies. Deficiency can lead, at the same time, to oxidative stress and an increase in inflammation as well as the expression of particular immune cells that play a pivotal role in the development of atherosclerosis in the intima of the blood vessels, i.e., monocytes and macrophages. Vitamin D is also involved in atherogenesis through inhibition of vascular smooth muscle cell proliferation. Furthermore, vitamin D deficiency is consistently associated with cardiovascular events, such as myocardial infarction, STEMI, NSTEMI, unstable angina, ischemic stroke, cardiovascular death, and increased mortality after acute stroke. Conversely, vitamin D supplementation does not seem to produce beneficial effects in cohorts with intermediate baseline vitamin D levels.

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Variable Genomic and Metabolomic Responses to Varying Doses of Vitamin D Supplementation

Cited by 25 publications

References 24 publications

Vitamin D and Rheumatic Diseases: A Review of Clinical Evidence

Vitamin D and Rheumatic Diseases: A Review of Clinical Evidence

Immunologic Effects of Vitamin D on Human Health and Disease

Vitamin D and Its Role in the Lipid Metabolism and the Development of Atherosclerosis

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