2020
DOI: 10.3389/fphar.2019.01599
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Variable in Vivo and in Vitro Biological Effects of Cerium Oxide Nanoparticle Formulations

Abstract: Cerium oxide nanoparticles (CeNPs) exhibit redox capacity in vitro with efficacy in in vivo disease models of oxidative stress. Here we compare, in parallel, three CeNP formulations with distinct chemical stabilizers and size. In vitro assays revealed antioxidant activity from all the CeNPs, but when administered to mice with a reactive oxygen species (ROS) mediated model of multiple sclerosis, only custom-synthesized Cerion NRx (CNRx) citrate-EDTA stabilized CeNPs provided protection against disease. Detectab… Show more

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Cited by 15 publications
(13 citation statements)
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“…Also, glutathione-S-transferase (GST) activities, a phase II xenobiotic detoxification enzyme, and reduced GSH levels were reduced in [NMU + BaP] administered rats. These findings are in agreement with the results of Palmer et al [30] and Fangzhou et al [40] who reported a significant decrease in antioxidant enzymes treatment of cancers, such as melanoma, [43] pancreatic cancer, [44] and colorectal cancer. [12] Also, cerium oxide nanoparticles protected gastrointestinal epithelial cell lines and normal human colon cells from radiation-induced damage by reducing the levels of ROS.…”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“…Also, glutathione-S-transferase (GST) activities, a phase II xenobiotic detoxification enzyme, and reduced GSH levels were reduced in [NMU + BaP] administered rats. These findings are in agreement with the results of Palmer et al [30] and Fangzhou et al [40] who reported a significant decrease in antioxidant enzymes treatment of cancers, such as melanoma, [43] pancreatic cancer, [44] and colorectal cancer. [12] Also, cerium oxide nanoparticles protected gastrointestinal epithelial cell lines and normal human colon cells from radiation-induced damage by reducing the levels of ROS.…”
Section: Discussionsupporting
confidence: 92%
“…It was however observed that administration of cerium oxide nanoparticles to [NMU + BaP] rats increased the activities of the antioxidant enzymes. It has been reported that cerium oxide nanoparticles may be a possibly effective drug candidate for the treatment of cancers, such as melanoma, [ 43 ] pancreatic cancer, [ 44 ] and colorectal cancer. [ 12 ] Also, cerium oxide nanoparticles protected gastrointestinal epithelial cell lines and normal human colon cells from radiation‐induced damage by reducing the levels of ROS.…”
Section: Discussionmentioning
confidence: 99%
“…Similarly, U-87MG exhibited lesser cytotoxicity on treatment with NPs to the free drug (Supplementary Table 4 ). However, the therapeutic potential of nanoparticle can better be estimated in vivo tumor environment 33 .…”
Section: Resultsmentioning
confidence: 99%
“…In addition, its trivalent cation, Ce 3+ , exhibits some biologically important properties such as antiseptic and virus-removal characteristics and potential anticancer activities, and it promotes the proliferation of fibroblasts and osteoblasts . Because Ce 3+ is similar to Ca 2+ in terms of its outermost electron configuration, Ce 3+ is expected to provide various biological effects, which enables replacing biomolecules in vivo. , Therefore, understanding the fundamental properties of Ce 3+ and its interactions with other molecules is extremely important, especially from the viewpoint of potential applications.…”
Section: Introductionmentioning
confidence: 99%
“…13 Because Ce 3+ is similar to Ca 2+ in terms of its outermost electron configuration, Ce 3+ is expected to provide various biological effects, which enables replacing biomolecules in vivo. 14,15 Therefore, understanding the fundamental properties of Ce 3+ and its interactions with other molecules is extremely important, especially from the viewpoint of potential applications.…”
Section: ■ Introductionmentioning
confidence: 99%