Variable susceptibility of Lewis rats to experimental autoimmune encephalomyelitis

Gould, Karen E.; Stepaniak, Jolie A.; Swanborg, Robert H.

doi:10.1016/0165-5728(94)90240-2

Cited by 17 publications

(13 citation statements)

References 5 publications

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“…Variations in clinical scores between vehicle-treated groups do occur not infrequently and may be attributed to the animal batches themselves. It has recently been reported that Lewis rats vary considerably with respect to susceptibility to EAE, depending on the commercial source [24]. Furthermore, responses to the stress of sham treatment, which can activate the adrenal cortex, may also modulate the disease process [25].…”

Section: Discussionmentioning

confidence: 99%

Suppression of experimental allergic encephalomyelitis in the Lewis rat by the matrix metalloproteinase inhibitor Ro31-9790

et al. 1995

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Matrix metalloproteinases (MMPs) are implicated in the tissue destruction associated with inflammatory demyelinating diseases such as multiple sclerosis. The effect of a hydroxamate inhibitor of MMPs, Ro31-9790, on inflammatory demyelination was assessed in two acute models of experimental allergic encephalomyelitis (EAE). Daily intraperitoneal injections of Ro31-9790 (50 mg kg-1), beginning either at the time of disease induction or from day 3 post induction, significantly reduced the clinical severity of adoptively transferred EAE. Administration of the inhibitor from the day of induction of active EAE prevented disease onset in 9/10 animals. However, in a repeat study, in which clinical disease was much more severe in the vesicle treated animals, the inhibitor was less effective. Clinical signs and CNS histopathology correlated well, with greater numbers of inflammatory lesions associated with increased disease severity. The present study confirms a role for then MMP cascade in inflammation in EAE.

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Section: Discussionmentioning

confidence: 99%

Suppression of experimental allergic encephalomyelitis in the Lewis rat by the matrix metalloproteinase inhibitor Ro31-9790

et al. 1995

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“…In this strain, after spontaneous recovery, EAE cannot be induced again (Willenborg, ). Because this strain is syngeneic, passive EAE can be induced to define a role of T cells (Gould et al, ). Further, there are no sex differences in inducing a disease.…”

Section: Selection Of Animals In Eaementioning

confidence: 99%

Animal models of multiple sclerosis: Focus on experimental autoimmune encephalomyelitis

Bjelobaba

Begović-Kuprešanin

Peković

et al. 2018

J of Neuroscience Research

137

102

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Multiple sclerosis (MS) is a chronic, progressive disorder of the central nervous system (CNS) that affects more than two million people worldwide. Several animal models resemble MS pathology; the most employed are experimental autoimmune encephalomyelitis (EAE) and toxin- and/or virus-induced demyelination. In this review we will summarize our knowledge on the utility of different animal models in MS research. Although animal models cannot replicate the complexity and heterogeneity of the MS pathology, they have proved to be useful for the development of several drugs approved for treatment of MS patients. This review focuses on EAE because it represents both clinical and pathological features of MS. During the past decades, EAE has been effective in illuminating various pathological processes that occur during MS, including inflammation, CNS penetration, demyelination, axonopathy, and neuron loss mediated by immune cells.

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“…Lewis rats have been widely used as an animal model for experimental studies of the pathogenesis and treatment of autoimmune disorders in humans such as EAE for MS (Chung et al,1991) and EAN for GBS (Zhu et al,1998a,b; Gold et al,2000; Kieseier et al,2004). However, in EAE, this kind of study revealed considerable variation with respect to disease susceptibility between different strains in the mouse system (Binder et al,1991; Encinas et al,1996; Mix et al,2004), in guinea pigs and hamsters (Encinas et al,1996), and in rats (Encinas et al,1996), including Lewis rats (Gould et al,1994; Zorzella et al,2007). As a reason for these differences, active suppressor mechanisms (Mix et al,2004) or exogenous factors such as housing conditions (Zorzella et al,2007) have been suggested.…”

Section: Discussionmentioning

confidence: 99%

Differential susceptibility to experimental autoimmune neuritis in Lewis rat strains is associated with T-cell immunity to myelin antigens

et al. 2010

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Experimental autoimmune neuritis (EAN) is a CD4(+) T-cell-mediated inflammatory demyelinating disease of the peripheral nervous system (PNS) that serves as a model for Guillain-Barré syndrome (GBS) in humans. Various rat strains show different susceptibility to EAN. We examined PNS myelin-induced T- and B-cell responses and cytokine production in order to explore the mechanisms behind different EAN susceptibility in the three Lewis rat strains, Hannover, Charles River, and Taconic. Lewis rats of Hannover and Charles River strains exhibited a higher susceptibility to EAN than Lewis rats of the Taconic strain. The higher susceptibility was associated with increased inflammatory cell infiltrates and major histocompatibility class II expression as well as enhanced mitogenic (phytohemagglutinin-induced) and antigen-specific (P2 peptide 57-81-induced) lymphocyte proliferation compared with the Taconic strain. The Hannover strain also showed increased proinflammatory cytokine (interferon-γ and tumor necrosis factor-α) production in the PNS. Cross-cultures of T cells and macrophages from Hannover and Taconic rats revealed that the Hannover rats exerted the strongest priming function of T cells. In contract, the P2 peptide-induced antibody production was not different among the three Lewis rat strains. In conclusion, the differential susceptibility to EAN of Lewis rat strains is correlated primarily with T-cell immunity to myelin antigens.

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Variable susceptibility of Lewis rats to experimental autoimmune encephalomyelitis

Cited by 17 publications

References 5 publications

Suppression of experimental allergic encephalomyelitis in the Lewis rat by the matrix metalloproteinase inhibitor Ro31-9790

Suppression of experimental allergic encephalomyelitis in the Lewis rat by the matrix metalloproteinase inhibitor Ro31-9790

Animal models of multiple sclerosis: Focus on experimental autoimmune encephalomyelitis

Differential susceptibility to experimental autoimmune neuritis in Lewis rat strains is associated with T-cell immunity to myelin antigens

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