Variables affecting quality of life after Radical cystectomy and neobladder substitution: Egyptian National Cancer Institute experience

Azab, Abdou El; Hossam, Eslam; AbdelRahman, Islam Fathy Soliman; Aboulkassem, H; Fadlalla, Waleed Mohamed; Abdelbary, Ahmed

doi:10.1016/j.purol.2021.07.002

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…8,9 These include preoperative performance status scores, nerve-sparing surgery, urinary incontinence, non-nerve-sparing surgery, and ureteral stenosis. 10 Despite the potential benefits of orthotopic diversion, its use is decreasing with the shift to minimally invasive surgical techniques. 11 However, a study comparing open and laparoscopic radical cystectomy for neobladder found promising peri-and post-operative outcomes for laparoscopic surgery, including smaller incision length, less pain and complications, and faster recovery.…”

Section: Introductionmentioning

confidence: 99%

“…Research has identified several factors that may affect the quality of life in orthotopic neobladder patients 8,9 . These include preoperative performance status scores, nerve‐sparing surgery, urinary incontinence, non‐nerve‐sparing surgery, and ureteral stenosis 10 . Despite the potential benefits of orthotopic diversion, its use is decreasing with the shift to minimally invasive surgical techniques 11 .…”

Section: Introductionmentioning

confidence: 99%

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Effect of orthotopic neobladder reconstruction on quality of life: A systematic review

Özer Özlü,

Çolak,

Vural

2024

Int J of Uro Nursing

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How does orthotopic neobladder reconstruction in the surgical treatment of bladder cancer patients affect the quality of life? In the literature, the results affecting the quality of life from patient‐reported outcome measures in bladder cancer patients who underwent orthotopic neobladder are not fully known. In this systematic review, the effect of orthotopic neobladder reconstruction on the quality of life in patients with bladder cancer is examined. Literature search was conducted within the framework of PRISMA guidelines and PICO. The research question was conducted in line with the core elements of Population, Concept and Context (PCC) proposed by the Joanna Briggs Institute (JBI) methodology. In the study, international studies published in Medline/PubMed, Cochrane, Web of Science, ProQuest and Scopus databases between 2012 and 2022 and accessible with the keywords ‘quality of life, ileal conduit, orthotopic neobladder, and continent diversion’ were reviewed. Methodological evaluation was performed by three independent authors with the JBI checklist. Six cross‐sectional studies with 1485 samples and 12 prospective cohort studies with 1555 samples were included in the review. The Cronbach's alpha coefficient of the checklists was 0.98 in cross‐sectional studies and 0.97 in prospective cohort studies. In studies, it was observed that the European Organization for Research and Treatment of Cancer‐Quality of Life (EORTC‐Quality of Life) scale was mostly used in patients' quality of life. In cross‐sectional studies, there is no difference in quality of life between orthotopic neobladder and continent diversions, the quality of life related to bowel function is high in orthotopic neobladder, the quality of life related to urinary and sexual function is low, different surgical techniques in orthotopic neobladder do not affect the quality of life between women and men. It was determined that the factors affecting the quality of life were different and that chemotherapy and radiotherapy had different effects on the quality of life. In prospective cohort studies, it was found that comorbid diseases affect the quality of life, but orthotopic neobladder improves the quality of life of patients in the long term, there is no difference in quality of life between incontinent and continent diversions, and orthotopic neobladder has a positive effect on quality of life, especially in women. The studies conducted show that the studies on the quality of life of patients with orthotopic neobladder are limited and studies with strong effect sizes are needed. This review recommends that more studies be conducted to improve the physical‐psychological health, social relationships and environmental quality of life of patients with orthotopic neobladder and that support programs be developed for these patients.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of orthotopic neobladder reconstruction on quality of life: A systematic review

Özer Özlü,

Çolak,

Vural

2024

Int J of Uro Nursing

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Factors influencing health-related quality of life in patients with bladder or kidney cancer: a prospective cohort study of the impact of nutritional status and frailty phenotype

dos Reis,

Martucci

2024

J Cancer Surviv

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Long-term follow-up results of prostate capsule-sparing and nerve-sparing radical cystectomy with neobladder: a single-center retrospective analysis

Zhu,

Shi

et al. 2024

Front. Urol.

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ObjectiveThis study aims to investigate and analyze the feasibility, oncological outcomes, functional efficacy, and complications with the prostatic capsule sparing (PCS) as well as the nerve sparing (NS) in radical cystectomy for bladder cancer.Patients and methodsBetween January 2007 and December 2021, 67 total cystectomies with PCS and 54 with NS were performed at our institution. The inclusion criteria for PCS were as follows: proactive, fully informed patient consent; negative transurethral resection of the bladder neck; normal prostate-specific antigen (PSA) level < 4 ng/dL; and normal transrectal ultrasonography with biopsy of any suspicious nodes. Patients received complete oncological and functional follow-ups. The Kaplan-Meier method was utilized to characterize survival outcomes after surgery.ResultsThe median follow-up times for PCS and NS were 144 and 122 months, respectively. Cumulative survival estimated the 5- and 10-years cancer-specific survival were 93.0% and 88.7% for the PCS group and 79.7% and 79.6% for the NS group, respectively (p = 0.123). In terms of function, the daytime urinary control at 3, 6, and 12 months postoperatively was 80.60%, 97.01%, and 100% in the PCS group, and 53.70%, 85.19%, and 94.44% in the NS group, respectively (p = 0.002, 0.023, and 0.100); and nocturnal urinary control was 62.69%, 94.03%, and 98.51% in the PCS group, and 40.74%, 72.22%, and 87.04% in the NS group, respectively (p = 0.016, 0.001, and 0.022). The erectile function recovery revealed that 62.69% and 40.74% of patients returned to preoperative levels (International Index of Erectile Function (IIEF)-5 score ≥ 15) in the PCS and NS groups, respectively (p = 0.016). Considering complications within 30 days after surgery, 4.48% and 7.69% patients had Clavien ≥ III complications in the PCS and NS groups, respectively (p = 0.700).ConclusionThe PCS provides better restored urinary control and sexual function than the NS technique and does not affect oncological outcomes. However, PCS is prone to bladder-neck obstruction complications and requires closer long-term follow-up.

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Variables affecting quality of life after Radical cystectomy and neobladder substitution: Egyptian National Cancer Institute experience

Cited by 3 publications

References 32 publications

Effect of orthotopic neobladder reconstruction on quality of life: A systematic review

Effect of orthotopic neobladder reconstruction on quality of life: A systematic review

Factors influencing health-related quality of life in patients with bladder or kidney cancer: a prospective cohort study of the impact of nutritional status and frailty phenotype

Long-term follow-up results of prostate capsule-sparing and nerve-sparing radical cystectomy with neobladder: a single-center retrospective analysis

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