Variables associated with physical health-related quality of life in Parkinson’s disease patients presenting for deep brain stimulation

Diaz, Alexandre Paim; Freitas, Fernando Cini; Thais, Maria Emília de Oliveira; Arêas, Fernando Zanela da Silva; Schwarzbold, Marcelo Libório; Debona, R.; Nunes, Jean Costa; Guarnieri, Ricardo; Martínez-Ramírez, Daniel; Prediger, Rui Daniel; Shukla, Aparna Wagle; Linhares, Marcelo Neves; Walz, Roger

doi:10.1007/s10072-016-2681-z

Cited by 9 publications

(1 citation statement)

References 34 publications

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“…However, functioning regressed progressively to baseline after 5 years [1]. These observations are point of contentions in several studies and are attributed to several confounding factors [5].…”

Section: Introductionmentioning

confidence: 94%

Impact of deep brain stimulation on quality of life and motor symptoms in Parkinson's disease and X-linked dystonia parkinsonism: The Philippine experience

Dannug

Gabriel

Macias

et al. 2021

Parkinsonism & Related Disorders

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Background and objectives: Deep brain stimulation (DBS) is indisputable in improving motor symptoms of Parkinson's Disease (PD) and X-Linked Dystonia Parkinsonism (XDP) (4,9,22,23,26). However, a discrepancy between this improvement and the perceived quality of life (QoL) has been observed. This study aims to investigate changes and correlation between quality of life, motor symptoms and medication dosing. Methodology: This prospective observational study enrolled 13 patients (6 PD, 7 XDP) who underwent DBS from 2017 to 2018. Quality of life changes were determined by Parkinson's Disease -39 (PDQ-39 English and Filipino versions) at baseline, 6 months and 12 month after DBS. Motor symptoms and medication dosing were also evaluated within the same period and correlated with QoL changes. Results and discussion: There is a significant reduction of PDQ-39 mean scores[F(1.06,11.64) = 18.235; p = 0.001; ηp2 = 0.624] between baseline and 6 months among XDP patients (p = 0.018) and baseline and 12 months among PD patients (p = 0.027) and XDP patients (p < 0.001). Specific domains with significant improvement were stigma, cognition, mobility, ADLs, communication and bodily discomfort. Correlating these with changes in motor symptoms, only mobility for PD and ADLs for XDP were positively related. Conclusion:This study has shown the positive impact of DBS in improving QoL among PD and XDP patients over a 12-month period.

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Section: Introductionmentioning

confidence: 94%

Impact of deep brain stimulation on quality of life and motor symptoms in Parkinson's disease and X-linked dystonia parkinsonism: The Philippine experience

Dannug

Gabriel

Macias

et al. 2021

Parkinsonism & Related Disorders

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Continuous quantitative monitoring of physical activity in Parkinson’s disease patients by using wearable devices: a case-control study

et al. 2017

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The objective of this study was to explore the feasibility of using wearable devices to quantitatively measure the daily activity in patients with Parkinson's disease (PD) and to monitor medication-induced motor fluctuations. In this case-controlled study, we used monitored daily movement function in 21 patients with Parkinson's disease and 20 healthy volunteers. We analyzed the exercise types and sleep duration in the two groups and evaluated the correlation between daily movement function and age, gender, education, disease duration, Hohn-Yahr stage, UPDRS-II score, UPDRS-III score, and levodopa dose. We also determined the amount of exercise performed by PD patients at 1 h after taking levodopa and at 1 h before the next dose. The type of activity, average speed, and sleep duration in patients were significantly lower in PD patients than in healthy controls (P < 0.05). One hour after taking levodopa, patients were significantly more active than 1 h before the next dose (P < 0.05).Correlation analysis showed that age, gender, education, disease duration, Hohn-Yahr stage, UPDRS-II and UPDRS-III scores, and dosage of levodopa do not correlate with the daily movement function (P > 0.05) in patients with Parkinson's disease. In the control group, age and education were associated with daily movement function (P < 0.05), while gender was unrelated (P > 0.05). Continuous monitoring of daily activity may be useful to reveal medication-induced motor fluctuations in Parkinson's disease. The daily movement function may depend on age and education, but not on other parameters.

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A novel device for continuous monitoring of tremor and other motor symptoms

Battista

Romaniello

2018

Neurol Sci

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The clinical assessment of Parkinson's disease (PD) symptoms is typically performed with neurological examinations and simple motor tests. However, this only takes into account the severity of motor symptoms during the length of the recording and fails to capture variations in a patient's motor state, which change continuously during the day. Most of the current methods for long-term monitoring of extrapyramidal symptoms are based on the use of a wearable magneto-inertial device that evaluates the frequential content of signals in the range of movement disorders. However, the typical daily motor activities performed by patients may have a power spectrum into the same range of motor symptoms, and habitual activity may be indistinguishable from that due to movement disorders. In this work, we report a new device and method for the continuous and long-term monitoring of tremor due to PD and other movement disorders to reduce the probability of mistaking the discrimination between extrapyramidal symptoms and normal daily activity. The method is based on the evaluation of frequential data content from multi-axial sensors and on the identification of specific movement patterns that Parkinsonian and extrapyramidal symptoms are typically associated with. In this study, 16 patients with movement disorders were recruited. While results need to be extended with further studies and clinical trials, the proposed device appears promising and suitable for the use as part of clinical trials and routine clinical practice for supporting the evaluation of motor symptoms, disease progression, and the quantification of therapeutic effects.

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Variables associated with physical health-related quality of life in Parkinson’s disease patients presenting for deep brain stimulation

Cited by 9 publications

References 34 publications

Impact of deep brain stimulation on quality of life and motor symptoms in Parkinson's disease and X-linked dystonia parkinsonism: The Philippine experience

Impact of deep brain stimulation on quality of life and motor symptoms in Parkinson's disease and X-linked dystonia parkinsonism: The Philippine experience

Continuous quantitative monitoring of physical activity in Parkinson’s disease patients by using wearable devices: a case-control study

A novel device for continuous monitoring of tremor and other motor symptoms

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