Variables influencing antidepressant medication adherence for treating outpatients with depressive disorders

Lee, Moon Soo; Lee, Hwa Young; Na, Kyoung-Sae; Yang, Jung‐Seok; Ahn, Hyonggin; Rhee, Min Kyu; Ko, Young Hoon; Joe, Sook Haeng; Jung, In Kwa; Kim, Seung Hyun

doi:10.1016/j.jad.2009.10.002

Cited by 57 publications

(39 citation statements)

References 27 publications

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“…Moreover, different factors could be related to non-adherence: side effects, severity of the disease, co-morbidity, personal characteristics and health provider support [11,12].…”

Section: Introductionmentioning

confidence: 99%

Patterns of Antidepressant Use in Italy: Therapy Duration, Adherence and Switching

Esposti¹,

Piccinni

Sangiorgi³

et al. 2015

Clin Drug Investig

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“…Moreover, different factors could be related to non-adherence: side effects, severity of the disease, co-morbidity, personal characteristics and health provider support [11,12].…”

Section: Introductionmentioning

confidence: 99%

Patterns of Antidepressant Use in Italy: Therapy Duration, Adherence and Switching

Esposti¹,

Piccinni

Sangiorgi³

et al. 2015

Clin Drug Investig

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“…The MEMS ® has been used to study adherence in patients with HIV, 8,16-18 diabetes, 9,19,20 depressive disorders, 21 and schizophrenia. 11 To our knowledge, this is the fi rst study to use MEMS ® technology to assess adherence in adult ADHD.…”

Section: Introductionmentioning

confidence: 99%

Medication Adherence and Symptom Reduction in Adults Treated with Mixed Amphetamine Salts in a Randomized Crossover Study

Adler¹,

Lynch²,

Shaw³

et al. 2011

Postgraduate Medicine

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“…However, studies of self-reported antidepressant adherence find that almost 30% of individuals poorly adhere to their prescribed treatment (1-4). Some reports have suggested that potentially more objective measures, such as medication possession ratios (MPRs), which are calculated from pharmacy data or pill counts, are associated with lower rates of adherence (46%–71%) (1, 3, 4). However, the concordance between self-report and objective measures of adherence varies (1, 3, 4).…”

mentioning

confidence: 99%

“…Some reports have suggested that potentially more objective measures, such as medication possession ratios (MPRs), which are calculated from pharmacy data or pill counts, are associated with lower rates of adherence (46%–71%) (1, 3, 4). However, the concordance between self-report and objective measures of adherence varies (1, 3, 4). Thus it is important to use a variety of adherence measures to understand factors associated with nonadherence and inform approaches to improving adherence.…”

mentioning

confidence: 99%

Predictors of Pharmacy-Based Measurement and Self-Report of Antidepressant Adherence: Are Individuals Overestimating Adherence?

Leggett

Ganoczy

Zivin

et al. 2016

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Objective The current study considers demographic, social, psychological, and clinical factors as predictors of adherence over time using both the Brief Medication Questionnaire (BMQ) based on self-report and medication possession ratios (MPRs) based on administrative pharmacy-data. Methods Adherence was assessed at 6 and 12 months among veterans in ongoing treatment for depression in a trial of peer support. Logistic regression models were utilized to consider predictors of adequate adherence. Results At 6 and 12 months, 36% and 35% of patients had poor adherence based on MPRs while 24% and 18% had poor adherence based on self-report. Poor adherence based on MPRs was more likely among men, non-whites, and those of Hispanic ethnicity. Poor self-reported adherence was more likely with increased depressive symptoms and unemployment. Conclusions These adherence measures may be complementary. Strategies to improve adherence might target specific demographic groups and those experiencing unemployment and higher levels of depressive symptoms.

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Variables influencing antidepressant medication adherence for treating outpatients with depressive disorders

Cited by 57 publications

References 27 publications

Patterns of Antidepressant Use in Italy: Therapy Duration, Adherence and Switching

Patterns of Antidepressant Use in Italy: Therapy Duration, Adherence and Switching

Medication Adherence and Symptom Reduction in Adults Treated with Mixed Amphetamine Salts in a Randomized Crossover Study

Predictors of Pharmacy-Based Measurement and Self-Report of Antidepressant Adherence: Are Individuals Overestimating Adherence?

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