Variables of Movement Amplitude and Frequency in the Development of Motion Sickness in Suncus murinus

Javid, Farideh A.; Naylor, R.J.

doi:10.1016/s0091-3057(99)00066-0

Cited by 33 publications

(23 citation statements)

References 17 publications

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“…Three stimuli known to reliably produce emesis in musk shrews (e.g., Refs. 16,19,27) were used: cisplatin (20 mg/kg ip; Sigma-Aldrich, cis-diamineplatinum dichloride, no. P4394), nicotine [2 mg/kg sc; Sigma-Aldrich, (Ϫ)-nicotine, no.…”

Section: Methodsmentioning

confidence: 99%

“…As a first step toward evaluating the potential impact that feeding may have on emesis we studied musk shrews, a well-established model of emesis (16,19,32). To expand on the findings that cannabinoids and ghrelin inhibit emesis, we sought to determine whether fasting, a natural stimulus for feeding and subsequent refeeding (sufficient to fill the stomach) would modify emesis induced by activation of different neural pathways: gut vagal afferents (using the cancer chemotherapy agent cisplatin) (4,19), the area postrema (using nicotine) (6,32), and the vestibular system (using horizontal motion) (16).…”

mentioning

confidence: 99%

“…To expand on the findings that cannabinoids and ghrelin inhibit emesis, we sought to determine whether fasting, a natural stimulus for feeding and subsequent refeeding (sufficient to fill the stomach) would modify emesis induced by activation of different neural pathways: gut vagal afferents (using the cancer chemotherapy agent cisplatin) (4,19), the area postrema (using nicotine) (6,32), and the vestibular system (using horizontal motion) (16). Our initial work used musk shrews originally derived from Guam.…”

mentioning

confidence: 99%

“…However, we discovered that this Guam strain was insensitive to motion-induced emesis, so we completed our studies using a Taiwan strain known to show a potent emetic response to motion (e.g., Refs. 2,8,16,31).…”

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confidence: 99%

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Food restriction, refeeding, and gastric fill fail to affect emesis in musk shrews

Horn

Still

Fitzgerald

et al. 2010

American Journal of Physiology-Gastrointestinal and Liver Physi

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Horn CC, Still L, Fitzgerald C, Friedman MI. Food restriction, refeeding, and gastric fill fail to affect emesis in musk shrews. Am J Physiol Gastrointest Liver Physiol 298: G25-G30, 2010. First published November 5, 2009 doi:10.1152/ajpgi.00366.2009.-Nausea and emesis are common side effects of gastrointestinal disease. Reports indicate that ghrelin and endocannabinoids, agents that stimulate appetite, also reduce emesis evoked by chemotherapy treatment, which suggests that stimulation of feeding inhibits the emetic system. In the following study we conducted a more direct test of this hypothesis by determining the impact of manipulating the motivation to eat on emesis, using food restriction and refeeding. Emesis was induced in musk shrews, a commonly used animal model for emesis research, using the cancer chemotherapy agent cisplatin (20 mg/kg ip), nicotine (2 mg/kg sc), or motion (1 Hz, horizontal, 4-cm displacement), because these treatments are known to target separate emetic pathways: gut vagal afferents, area postrema, and vestibular pathways, respectively. Twenty-four hours of food restriction was sufficient to stimulate food intake, and 1 h of refeeding filled the stomach. The results indicate that food restriction, refeeding, and gastric fill had no significant effects on the amount of emesis produced by any of the emetic treatments tested here. This suggests that, although activation of the emetic system might have prominent effects on food intake, neural controls for feeding behavior do not significantly affect the neural pathways for emesis. These results may have implications for how we treat patients who experience a constellation of side effects, including nausea and emesis, since stimulating appetite may not necessarily inhibit emetic pathways.

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Section: Methodsmentioning

confidence: 99%

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confidence: 99%

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Food restriction, refeeding, and gastric fill fail to affect emesis in musk shrews

Horn

Still

Fitzgerald

et al. 2010

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…Although data are scant this does seem to be true, since pigs [14] with similar mass to humans are made sick during transportation by low frequency oscillatory motion circa 0.2Hz. By contrast the small shrew, 'Suncus Murinus' [8] and broiler chickens [13] both have peak susceptibilities at much higher frequencies 1-2Hz. As with humans, animals round low frequency bends with body tilted and change direction at high frequencies using leg movement without body tilt.…”

Section: Discussionmentioning

confidence: 94%

Biodynamic Hypothesis for the Frequency Tuning of Motion Sickness

Golding

Gresty²

2016

aerosp med hum perform

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INTRODUCTION Motion sickness is often provoked by oscillatory translational (linear) acceleration. For humans, motion frequencies around 0.2-0.3Hz are the most provocative. A current explanation for this frequency band is that it spans a region of maximum ambiguity concerning the interpretation of vestibular signals. Below 0.2-0.3Hz linear accelerations are interpreted as 'tilt' whereas at higher frequencies accelerations are interpreted as 'translation', i.e., linear motion through space. This is termed the 'tilt-translation' hypothesis. However the origin of this particular frequency range is unclear. We investigated whether the differential perceptions of oscillations at different frequencies derives from the biodynamics of active self-initiated whole body motion. METHODS Video-films were taken of subjects running slaloms of various combinations of lengths/amplitudes to provoke a range of temporal frequencies of slalom (reciprocal of time to run a cycle). RESULTS The usual tactic for cornering at frequencies <0.25Hz was whole-body tilt whereas >0.4Hz lateropulsion of the legs with torso erect was observed. Between these frequencies subjects showed variable tactics, mixing components of both tilt and lateropulsion. CONCLUSIONS This uncertainty in selecting the appropriate tactic for movement control around 0.2-0.3Hz is the possible origin of 'tilt-translation' ambiguity. It also follows that externally imposed motion around these frequencies would challenge both perception and motor control; with the consequence of motion sickness.

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Descending projections of the hamster intergeniculate leaflet: Relationship to the sleep/arousal and visuomotor systems

Morin

Blanchard

2005

J. Comp. Neurol.

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The intergeniculate leaflet (IGL), homolog of the primate pregeniculate nucleus, modulates circadian rhythms. However, its extensive anatomical connections suggest that it may regulate other systems, particularly those for visuomotor function and sleep/arousal. Here, descending IGL-efferent pathways are identified with the anterograde tracer, Phaseolus vulgaris leucoagglutinin, with projections to over 50 brain stem nuclei. Projections of the ventral lateral geniculate are similar, but more limited. Many of the nuclei with IGL afferents contribute to circuitry governing visuomotor function. These include the oculomotor, trochlear, anterior pretectal, Edinger-Westphal, and the terminal nuclei; all layers of the superior colliculus, interstitial nucleus of the medial longitudinal fasciculus, supraoculomotor periaqueductal gray, nucleus of the optic tract, the inferior olive, and raphe interpositus. Other target nuclei are known to be involved in the regulation of sleep, including the lateral dorsal and pedunculopontine tegmentum. The dorsal raphe also receives projections from the IGL and may contribute to both sleep/arousal and visuomotor function. However, the locus coeruleus and medial vestibular nucleus, which contribute to sleep and eye movement regulation and which send projections to the IGL, do not receive reciprocal projections from it. The potential involvement of the IGL with the sleep/arousal system is further buttressed by existing evidence showing IGL-efferent projections to the ventrolateral preoptic area, dorsomedial, and medial tuberal hypothalamus. In addition, the great majority of all regions receiving IGL projections also receive input from the orexin/hypocretin system, suggesting that this system contributes not only to the regulation of sleep, but to eye movement control as well.

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Variables of Movement Amplitude and Frequency in the Development of Motion Sickness in Suncus murinus

Cited by 33 publications

References 17 publications

Food restriction, refeeding, and gastric fill fail to affect emesis in musk shrews

Food restriction, refeeding, and gastric fill fail to affect emesis in musk shrews

Biodynamic Hypothesis for the Frequency Tuning of Motion Sickness

Descending projections of the hamster intergeniculate leaflet: Relationship to the sleep/arousal and visuomotor systems

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