Variance of melatonin and cortisol rhythm in patients with allergic rhinitis

Fidan, Vural; Hakan, Hamit; Gözeler, Mustafa Sıtkı; Karaaslan, Önder; Binay, Omer; Cingi, Cemal

doi:10.1016/j.amjoto.2013.03.004

Cited by 22 publications

(19 citation statements)

References 17 publications

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“…Common types of slopes include: 1) wake-to-bed slopes , which examine the absolute change or rate of change in cortisol from immediately upon waking to late evening or bedtime (e.g., Adam et al, 2010; Turner-Cobb et al, 2011); 2) peak-to-bed slopes , which examine the absolute change or rate of change in cortisol from the peak of the CAR to late evening or bedtime, (e.g., Hsiao et al, 2010; Vammen et al, 2014); 3) short daytime slopes , which measure slopes over a shorter portion of the waking day, typically from several hours after waking to evening or bedtime ( late decline measures are one example of this; see Hajat et al, 2013); 4) fixed time point slopes (e.g., Bosch et al, 2007; Den Hartog et al, 2003), in which samples are gathered at fixed clock times across the day (e.g., 0800h and 2000h), rather than in relation to time of waking; and 5) amplitude measures , which estimate the peak-to-trough difference of the diurnal cortisol rhythm from intensive repeated measures of cortisol values across the day (e.g., Bao et al, 2004; Fidan et al, 2013a, Fidan et al, 2013b). …”

Section: Introductionmentioning

confidence: 99%

Diurnal cortisol slopes and mental and physical health outcomes: A systematic review and meta-analysis

Adam

Quinn

Tavernier

et al. 2017

Psychoneuroendocrinology

674

533

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Changes in levels of the stress-sensitive hormone cortisol from morning to evening are referred to as diurnal cortisol slopes. Flatter diurnal cortisol slopes have been proposed as a mediator between chronic psychosocial stress and poor mental and physical health outcomes in past theory and research. Surprisingly, neither a systematic nor a meta-analytic review of associations between diurnal cortisol slopes and health has been conducted to date, despite extensive literature on the topic. The current systematic review and meta-analysis examined associations between diurnal cortisol slopes and physical and mental health outcomes. Analyses were based on 179 associations from 80 studies for the time period up to January 31, 2015. Results indicated a significant association between flatter diurnal cortisol slopes and poorer health across all studies (average effect size, r = .147). Further, flatter diurnal cortisol slopes were associated with poorer health in 10 out of 12 subtypes of emotional and physical health outcomes examined. Among these subtypes, the effect size was largest for immune/inflammation outcomes (r = .288). Potential moderators of the associations between diurnal cortisol slopes and health outcomes were examined, including type of slope measure and study quality indices. The possible roles of flatter slopes as either a marker or a mechanism for disease etiology are discussed. We argue that flatter diurnal cortisol slopes may both reflect and contribute to stress-related dysregulation of central and peripheral circadian mechanisms, with corresponding downstream effects on multiple aspects of biology, behavior, and health.

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Section: Introductionmentioning

confidence: 99%

Diurnal cortisol slopes and mental and physical health outcomes: A systematic review and meta-analysis

Adam

Quinn

Tavernier

et al. 2017

Psychoneuroendocrinology

674

533

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“…Basophil reactivity shows daily variations depending on the circadian clock activity in basophils, which could partly explain temporal symptomatic variations in allergic rhinitis. The circadian rhythms of salivary melatonin and cortisol were found to be disrupted in patients with allergic rhinitis [ 65 ]. Sleep impairment is very common in allergic rhinitis patients and has a significant impact on disease-specific measures of general health and quality of life.…”

Section: Biological Clocks and Allergic Diseasesmentioning

confidence: 99%

Biological clocks: their relevance to immune-allergic diseases

2018

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The 2017 Nobel Prize for Physiology or Medicine, awarded for the discoveries made in the past 15 years on the genetic and molecular mechanisms regulating many physiological functions, has renewed the attention to the importance of circadian rhythms. These originate from a central pacemaker in the suprachiasmatic nucleus in the brain, photoentrained via direct connection with melanopsin containing, intrinsically light-sensitive retinal ganglion cells, and it projects to periphery, thus creating an inner circadian rhythm. This regulates several activities, including sleep, feeding times, energy metabolism, endocrine and immune functions. Disturbances of these rhythms, mainly of wake/sleep, hormonal secretion and feeding, cause decrease in quality of life, as well as being involved in development of obesity, metabolic syndrome and neuropsychiatric disorders. Most immunological functions, from leukocyte numbers, activity and cytokine secretion undergo circadian variations, which might affect susceptibility to infections. The intensity of symptoms and disease severity show a 24 h pattern in many immunological and allergic diseases, including rheumatoid arthritis, bronchial asthma, atopic eczema and chronic urticaria. This is accompanied by altered sleep duration and quality, a major determinant of quality of life. Shift work and travel through time zones as well as artificial light pose new health threats by disrupting the circadian rhythms. Finally, the field of chronopharmacology uses these concepts for delivering drugs in synchrony with biological rhythms.

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“…Importantly, the upper airway obstruction that characterizes AR is a risk factor for sleep disordered breathing events, such as apnoeas, hypopneas and snoring in adults and children (Long 2007). AR patients have daily rhythms of salivary melatonin that have a decreased amplitude, baseline and peak levels, as well as lower amplitude of salivary cortisol daily rhythm and delayed peak compared to healthy controls (Fidan et al 2013). The reason for the lower robustness of these rhythms is unknown but may be due to sleep disruption and/or as a consequence of inflammation.…”

Section: Allergic Rhinitismentioning

confidence: 99%

A circadian based inflammatory response – implications for respiratory disease and treatment

Comas

Gordon

Oliver

et al. 2017

Sleep Science Practice

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Circadian clocks regulate the daily timing of many of our physiological, metabolic and biochemical functions. The immune system also displays circadian oscillations in immune cell count, synthesis and cytokine release, clock gene expression in cells and organs of the immune system as well as clock-controlled genes that regulate immune function. Circadian disruption leads to dysregulation of immune responses and inflammation which can further disrupt circadian rhythms. The response of organisms to immune challenges, such as allergic reactions also vary depending on time of the day, which can lead to detrimental responses particularly during the rest and early active periods. This review evaluates what is currently known in terms of circadian biology of immune response and the cross-talk between circadian and immune system. We discuss the circadian pattern of three respiratory-related inflammatory diseases, chronic obstructive pulmonary disease, allergic rhinitis and asthma. Increasing our knowledge on circadian patterns of immune responses and developing chronotherapeutic studies in inflammatory diseases with strong circadian patterns will lead to preventive measures as well as improved therapies focussing on the circadian rhythms of symptoms and the daily variation of the patients' responses to medication.

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Variance of melatonin and cortisol rhythm in patients with allergic rhinitis

Cited by 22 publications

References 17 publications

Diurnal cortisol slopes and mental and physical health outcomes: A systematic review and meta-analysis

Diurnal cortisol slopes and mental and physical health outcomes: A systematic review and meta-analysis

Biological clocks: their relevance to immune-allergic diseases

A circadian based inflammatory response – implications for respiratory disease and treatment

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