Variant (8;22) Translocation in Lymphoblastic Lymphoma

Slavutsky, Irma; Andreoli, Gabriela; Gutiérrez, Marina; Narbaitz, Marina; Lucero, Graciela; Eppinger, Marion

doi:10.3109/10428199609067595

Cited by 12 publications

(8 citation statements)

References 10 publications

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“…Since 1980, only 13 cases of B-ALL/LBL with isolated MYC rearrangement were reported 15–23 . Like other B-ALL/LBLs, the majority of the cases occurred in pediatric patients and only three cases were reported in adults 17, 24, 25 (Table 1), including two cases of B-ALL and one case of B-LBL without bone marrow involvement 25 . The majority of the cases demonstrated Burkitt-like morphology.…”

Section: Discussionmentioning

confidence: 99%

B Lymphoblastic Leukemia/Lymphoma With Burkitt-like Morphology and IGH/MYC Rearrangement

Gupta

Molofsky

et al. 2018

American Journal of Surgical Pathology

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Isolated MYC rearrangement without other recurrent genetic abnormalities is rare in B lymphoblastic leukemia/lymphoma (B-ALL/LBL), with most cases reported in pediatric patients. We report 3 adult cases with lymphoblasts showing a precursor B cell immunophenotype, and isolated MYC/IGH translocation. All 3 cases occurred in male patients with initial presentation of diffuse lymphadenopathy. Cases 1 and 2 had B-ALL with significantly increased lymphoblasts in peripheral blood and bone marrow. Case 3, a patient with human immunodeficiency virus infection, had the diagnosis of B-LBL made on a retroperitoneal lymph node biopsy and had no peripheral blood or bone marrow involvement. The leukemic and lymphoma cells in all 3 cases demonstrated Burkitt lymphoma-like morphology with deeply basophilic cytoplasm and numerous cytoplasmic vacuoles. However, all 3 had immature immunophenotypes including expression of terminal deoxynucleotidyl transferase (TdT), absence of BCL6, and dim-to-negative CD45. CD20 was largely negative in 2 of 3 cases. All 3 had confirmed MYC/IGH translocation, but lacked rearrangements of BCL2 or BCL6. EBV was negative by Epstein-Barr virus encoded small RNA in situ hybridization. Treatment protocols varied, including both high-risk ALL-type (protocol 8707) and high-grade lymphoma regimens (hyper-CVAD [cyclophosphamide, vincristine, adriamycin, and dexamethasone]), but no patient achieved continuous complete remission. These cases seem to represent a distinct biological phenomenon, in which a MYC translocation may be acquired at an immature stage of differentiation, thus manifesting features of both B-ALL/LBL and Burkitt lymphoma.

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Section: Discussionmentioning

confidence: 99%

B Lymphoblastic Leukemia/Lymphoma With Burkitt-like Morphology and IGH/MYC Rearrangement

Gupta

Molofsky

et al. 2018

American Journal of Surgical Pathology

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“…The neoplastic cells usually express CD19, CD20, and CD10 (5,6). Although identification of c-myc rearrangement is prerequisite to a diagnosis of BL, it is occasionally seen in other B-cell neoplasms, such as diffuse large B-cell lymphoma (DLBCL), lymphoblastic lymphoma (LBL), follicular lymphoma (FL), and multiple myeloma (MM) (7)(8)(9)(10)(11)(12)(13)(14). Most cases of LBL, while showing a starry-sky appearance, can be easily distinguished from BL by their convoluted nuclei with fine chromatin and detection of antigens such as TdT.…”

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confidence: 99%

The Distinction between Burkitt Lymphoma and Diffuse Large B-Cell Lymphoma with c-myc Rearrangement

et al. 2002

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To compare immunophenotypic and molecular features between Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) with c-myc rearrangements (c-myc R DLBCL), we analyzed 18 cases of B-cell non-Hodgkin's lymphoma with c-myc R that were confirmed by chromosomal and/or Southern blotting analyses. The cases were histologically classified into 10 BLs and five DLBCLs. The remaining three cases could not be classified because of suboptimal quality of the surgical materials. BLs were from five adults and five children, whereas all DLBCLs were from adults. BLs were positive for CD20 (10/10 cases examined), CD10 (9/ 10), Bcl-2 (1/9), and Bcl-6 (10/10), whereas they were negative for CD3 (

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“…[5] The second patient was a 20 year-old female with B-LL and translocation t (8;22). [6] In children, very few cases of B-ALL presenting with MYC translocation have been described. [7][8][9] In a study of pediatric B-ALL cases by the Pediatric Oncology Group (POG), MYC rearrangement with precursor B-cell phenotype was found in five out of 5,280 total cases.…”

Section: Discussionmentioning

confidence: 99%

“…A 64‐year‐old woman with B‐LL and MYC rearrangement had involvement of multiple extranodal lesions but no bone marrow involvement . The second patient was a 20 year‐old female with B‐LL and translocation t(8;22) . In children, very few cases of B‐ALL presenting with MYC translocation have been described .…”

Section: Discussionmentioning

confidence: 99%

Pediatric B-Cell Lymphoma With Lymphoblastic Morphology, TdT Expression,MYCRearrangement, and Features Overlapping With Burkitt Lymphoma

Meznarich

Miles

Paxton

et al. 2016

Pediatr Blood Cancer

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Burkitt lymphoma (BL) and B-lymphoblastic lymphoma are subtypes of pediatric non-Hodgkin lymphoma with different presenting features, treatment, and outcomes. This case report documents a 5-year-old female who presented with B-cell lymphoma with lymphoblastic morphology, terminal deoxynucleotidyl transferase expression, MYC rearrangement, and features overlapping with BL. Genomic microarray analysis identified a gain on the long arm of chromosome 1 without other definitive changes. She was treated according to a BL protocol and remains in remission 16-months after initial diagnosis.

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Variant (8;22) Translocation in Lymphoblastic Lymphoma

Cited by 12 publications

References 10 publications

B Lymphoblastic Leukemia/Lymphoma With Burkitt-like Morphology and IGH/MYC Rearrangement

B Lymphoblastic Leukemia/Lymphoma With Burkitt-like Morphology and IGH/MYC Rearrangement

The Distinction between Burkitt Lymphoma and Diffuse Large B-Cell Lymphoma with c-myc Rearrangement

Pediatric B-Cell Lymphoma With Lymphoblastic Morphology, TdT Expression,MYCRearrangement, and Features Overlapping With Burkitt Lymphoma

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