Variant acute promyelocytic leukemia translocation (15;17) originating from two subsequent balanced translocations involving the same chromosomes 15 and 17 while preserving the PML/RARA fusion

Tirado, Carlos A; Jahn, Jennifer; Scheerle, Jay; Eid, M O; Meister, Robert J.; Christie, Robert; Croft, Calvin D.; Wallingford, Steven; Mowrey, Philip N.; Meloni‐Ehrig, Aurelia

doi:10.1016/j.cancergencyto.2005.01.005

Cited by 8 publications

(7 citation statements)

References 9 publications

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“…To date, ~50 cases with three-way or more complex translocation variants of t(15;17)(q24;q21) have been reported (8)(9)(10)(11)(12)(13). Third or fourth breakpoints in complex translocations involving several chromosomes have been described, but a third breakpoint on the same chromosome 15 involved in the typical t(15;17)(q24;q21) is extremely rare (6).…”

Section: Discussionmentioning

confidence: 99%

“…Third or fourth breakpoints in three-way or more complex translocations have been reported, but they are likely to occur recurrently in particular chromosome bands, such as 1q36, 11q3, 2q21, 3p21, 4q21, 6q23, 19p13, 20p13, and Xq13 (5). However, a third breakpoint on the same chromosome 15 involved in the classical t(15;17)(q24;q21) defect is extremely rare, with only one case reported to date, to the best of the author's knowledge (6).…”

Section: Introductionmentioning

confidence: 98%

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A three‑way complex translocation of (15;15;17)(q24;q14;q21) involving two breakpoints on chromosome 15 in acute promyelocytic leukemia: A case report

Kim

2023

Oncol Lett

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The present study described an extremely rare case of acute promyelocytic leukemia (APL) characterized by a complex three-way (15;15;17)(q24;q14;q21) translocation. It was identified in a 59-year-old male through karyotype, molecular, and fluorescence in situ hybridization (FISH) analyses. The third translocation breakpoint 15q14 was identified on the same chromosome 15 that also contained the classical t(15;17)(q24;q21) and may have evolved from the classical t(15;17) clone, as indicated by interphase FISH analysis. A complex translocation involving two breakpoints on the same chromosome is extremely rare, such that this case can provide insights into complex translocations in APL.A three-way complex translocation of (15;15;17) (q24;q14;q21) involving two breakpoints on chromosome 15 in acute promyelocytic leukemia: A case report

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

A three‑way complex translocation of (15;15;17)(q24;q14;q21) involving two breakpoints on chromosome 15 in acute promyelocytic leukemia: A case report

Kim

2023

Oncol Lett

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“…The technical error might explain the discrepancy in one case between the results of conventional cell culture and molecular method. There have been several reports of rare cryptic translocations in APL, 23,24) and all of them showed superior results of molecular technique to conventional cell culture.…”

Section: Discussionmentioning

confidence: 99%

Ten-year Experience on Acute Promyelocytic Leukemia at Inha University Hospital

Lim

Park

et al. 2006

Korean J Hematol

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Background: Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia in its morphology as well as molecular or genetic profiles, conferring a good prognosis owing to the active roles of all-trans-retinoic acid (ATRA) and anthracyclines. Methods: Patients diagnosed as APL from March 1997 to April 2006 were analyzed on their clinical features, laboratory profiles, methods of treatment including remission induction, consolidation and maintenance, treatment outcomes, and treatment-related morbidity. Results: Chemotherapy naïve were all the 12 patients in our study consisting of 3 males and 9 females. All patients showed typical morphologic feature of APL with cytogenetic abnormality, t(15;17), and PML/RARα fusion gene was confirmed in 10 patients by FISH or PCR. The combination of cytarabine with daunorubicin (n=2) or idarubicin (n=9) was used as an induction regimen with concurrent ATRA administration. For consolidation therapy, cytarabine with anthracycline (n=4) or idarubicin monotherapy (n=8) was used with ATRA. Cytogenetic and molecular remissions were documented after induction chemotherapy (n=11) or first consolidation therapy (n=1). Maintenance therapy with ATRA was done in 11 patients. CR was obtained in 12 patients, with median remission duration of 30.5+ months (range 2 to 86+) at a median follow up duration of 33.5+ months (range 4 to 89+). One patient relapsed after completion of maintenance therapy and died of infection during reinduction chemotherapy. Conclusion: Herein is the report of ten years' experience of our hospital in the treatment of APL with favorable results as seen by high CR rate and fewer complications. (Korean J Hematol 2006;41:289-296.)

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“…O curso do prognóstico dos pacientes com LPA, que apresentam essas variantes complexas da t (15;17), onde a fusão PML-RARα se encontra intacta, parece não ser diferente do curso do prognóstico observado nos pacientes com a típica t (15;17). 54,55…”

Section: Rearranjo-pml-raraunclassified