2020
DOI: 10.21037/tcr-20-2169
|View full text |Cite
|
Sign up to set email alerts
|

Variant histology in bladder cancer: diagnostic and clinical implications

Abstract: Urothelial carcinoma differentiates into variant histological subtypes in approximately 25% of cases. Since every histological variant has unique characteristics, including metastatic potential, expression of immunotherapy targets, and susceptibility to radiation or chemotherapy, every variant offers a unique diagnostic and therapeutic challenge. However, since any single variant is relatively rare, there is a risk of missed pathological diagnosis and sub-optimal clinical management. Ensuring awareness among p… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

1
20
0

Year Published

2021
2021
2025
2025

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 37 publications
(21 citation statements)
references
References 55 publications
1
20
0
Order By: Relevance
“…Bladder cancer has a higher morbidity rate in males, with a 3 to 10 times higher incidence in males compared with females (2). Several risk factors are associated with bladder cancer, including industrial chemical contamination, poor dietary habits, and smoking (3). Surgery remains the primary treatment strategy for bladder cancer; however, an increase in its morbidity rate has been identified (4).…”
Section: Introductionmentioning
confidence: 99%
“…Bladder cancer has a higher morbidity rate in males, with a 3 to 10 times higher incidence in males compared with females (2). Several risk factors are associated with bladder cancer, including industrial chemical contamination, poor dietary habits, and smoking (3). Surgery remains the primary treatment strategy for bladder cancer; however, an increase in its morbidity rate has been identified (4).…”
Section: Introductionmentioning
confidence: 99%
“…Variant histologies account for up to 25% of all malignancies of the bladder but evidence of tumor biology is still limited as studies are highly heterogenous [ 15 ]. Due to major differences in tumor biology of histologic variants the lymphatic metastatic spread was reported to differ among histological origin [ 12 ].…”
Section: Discussionmentioning
confidence: 99%
“…Bladder cancer is one of the most fatal malignant tumors in humans, with high incidence, high recurrence rate, and high mortality. Over the past 2 decades, local or metastatic bladder cancer has a poor prognosis and a low 5-year survival rate due to uncontrolled proliferation, apoptosis, and metastasis of tumor cells (14). Studies have shown that local anesthetics may be beneficial to the treatment of cancer.…”
Section: Discussionmentioning
confidence: 99%