Variant of SNPs at lncRNA NEAT1 contributes to gastric cancer susceptibility in Chinese Han population

Ji, Xuanke; Yan, Yali; Ma, Nan; He, Gui; Wang, Kunyan; Zhang, Yuehua; Yin, Jingjing; Song, Chunhua; Wang, Peng; Ye, Hua; Dai, Liping; Zhang, Jianying; Wang, Kaijuan

doi:10.1007/s10147-020-01852-1

Cited by 4 publications

(3 citation statements)

References 28 publications

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“… 22 Similarly, the NEAT1 gene rs3825071 variant might affect gastric cancer susceptibility by modulated biological effects to improve the NEAT1 expression. 24 Another study indicated that NEAT1 gene rs3741384 variant might influence the survival of oral squamous cell carcinoma patients, and identified a predictive role of rs3741384 GG in a worse prognosis of this disease. 23 Previous studies had confirmed that a variety of lncRNA gene variants were associated with the genetic risk of PTB, moreover, the expression of NEAT1 in PTB patients was abnormal.…”

Section: Discussionmentioning

confidence: 99%

Association Between Genetic Polymorphisms of lncRNA NEAT1 and Pulmonary Tuberculosis Risk, Clinical Manifestations in a Chinese Population

Li¹,

Wang²,

Tang³

et al. 2022

IDR

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Background Recent studies have shown that abnormal expression of lncRNA NEAT1 is associated with the progression of pulmonary tuberculosis (PTB). The aim of our study was to analyze the relationship between single nucleotide polymorphisms (SNPs) of NEAT1 gene and susceptibility to PTB. Methods Four SNPs (rs2239895, rs3741384, rs3825071, rs512715) in NEAT1 gene were genotyped in 479 patients with PTB and 476 controls by improved multiple ligase detection reaction (iMLDR) in a Chinese population. Results We found no significant differences in allele and genotype frequencies of NEAT1 gene rs2239895, rs3741384, rs3825071, rs512715 between PTB patients and controls (all P > 0.05). There was no statistically significant association between genotype frequency distribution of dominant model, as well as recessive model, and genetic susceptibility to PTB patients (all P > 0.05). The TT genotype, T allele frequencies of rs3825071 were significantly increased in sputum smear-positive PTB patients when compared to sputum smear-negative PTB patients ( P = 0.010, P = 0.003, respectively). Haplotype analysis shown that NEAT1 haplotype frequency was not associated with PTB susceptibility. Conclusion NEAT1 gene polymorphisms were not associated with the risk of PTB in Chinese population, and rs3825071 polymorphism might be related to sputum smear-positive in PTB patients.

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Section: Discussionmentioning

confidence: 99%

Association Between Genetic Polymorphisms of lncRNA NEAT1 and Pulmonary Tuberculosis Risk, Clinical Manifestations in a Chinese Population

Li¹,

Wang²,

Tang³

et al. 2022

IDR

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“…Similarly, lncRNA Nuclear Paraspeckle Assembly Transcript 1 (NEAT1) was indicated to be lowly expressed in nasopharyngeal carcinoma cells that are resistant to histone deacetylase inhibitors and could improve the resistance of nasopharyngeal carcinoma to histone deacetylase inhibitors by regulating the miR-129/Bcl-2 axis [111]. SNP of rs3825071 affects its expression level [112]. Although there is no direct conclusion to prove the direct effect of these lncRNAs polymorphisms on chemotherapy response, based on the existing evidence, we speculate that the above three lncRNAs polymorphisms also affect chemotherapy resistance and deserve further exploration.…”

Section: Other Lncrnasmentioning

confidence: 99%

Role of Long Non-Coding RNA Polymorphisms in Cancer Chemotherapeutic Response

Zhang

et al. 2021

JPM

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Genetic polymorphisms are defined as the presence of two or more different alleles in the same locus, with a frequency higher than 1% in the population. Since the discovery of long non-coding RNAs (lncRNAs), which refer to a non-coding RNA with a length of more than 200 nucleotides, their biological roles have been increasingly revealed in recent years. They regulate many cellular processes, from pluripotency to cancer. Interestingly, abnormal expression or dysfunction of lncRNAs is closely related to the occurrence of human diseases, including cancer and degenerative neurological diseases. Particularly, their polymorphisms have been found to be associated with altered drug response and/or drug toxicity in cancer treatment. However, molecular mechanisms are not yet fully elucidated, which are expected to be discovered by detailed studies of RNA–protein, RNA–DNA, and RNA–lipid interactions. In conclusion, lncRNAs polymorphisms may become biomarkers for predicting the response to chemotherapy in cancer patients. Here we review and discuss how gene polymorphisms of lncRNAs affect cancer chemotherapeutic response. This knowledge may pave the way to personalized oncology treatments.

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“…The possible role of NEAT1 polymorphisms in other disorders, such as cancer, has been evaluated. Ji et al concluded that the G > A variant of rs3825071 might confer gastric cancer susceptibility that increases NEAT1 expression(21). Lin et al investigated the level of NEAT1 gene expression in oral squamous cell cancer (OSCC).…”

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confidence: 99%

Association Between NEAT1 rs512715 Gene polymorphism and Hashimoto Thyroiditis and Graves’ Disease: A Case-Control Study

Beiramzadeh¹,

Heidari²,

Saravani³

2023

Gene Cell Tissue

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Objectives: Some evidence demonstrated the relationship between long non - coding RNA and autoimmune disease development. The current study assessed the possible association between the nuclear enriched abundant transcript 1(NEAT1) gene rs512715 polymorphisms and Hashimoto and Graves’ diseases. Methods: Two hundred forty - eight participants with autoimmune thyroid disease (133 Hashimoto thyroiditis (HT) patients and 115 Graves’ disease (GD) patients) and 135 age - and sex - matched controls were enrolled in the study. The polymerase chain reaction - restriction fragment length polymorphism (PCR - RFLP) method was used for genotyping NEAT1 rs512715 polymorphism. Results: Significant differences were observed in the frequency of the CC genotype of rs512715 in the HT group compared to the controls; the CC genotype may act as a risk factor for HT development. Also, the dominant and recessive genetic models showed the same results. Regarding the frequency of alleles, the C allele frequency was higher in the HT group than in the controls. In the GD group, there was no significant difference in the distribution of genotypes and the genetic models. Also, no significant difference was observed in the frequencies of alleles in Graves’ patients. Conclusions: Our findings indicated that NEAT1 rs512715polymorphism might play an influential role in Hashimoto’s disease development as the risk factor.

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Variant of SNPs at lncRNA NEAT1 contributes to gastric cancer susceptibility in Chinese Han population

Cited by 4 publications

References 28 publications

Association Between Genetic Polymorphisms of lncRNA NEAT1 and Pulmonary Tuberculosis Risk, Clinical Manifestations in a Chinese Population

Association Between Genetic Polymorphisms of lncRNA NEAT1 and Pulmonary Tuberculosis Risk, Clinical Manifestations in a Chinese Population

Role of Long Non-Coding RNA Polymorphisms in Cancer Chemotherapeutic Response

Association Between NEAT1 rs512715 Gene polymorphism and Hashimoto Thyroiditis and Graves’ Disease: A Case-Control Study

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