Variant Strain of Propionibacterium Acnes: A Clue to the Aetiology of Kawasaki Disease

Kato, Hirohisa; Ito, Osamu; Koga, Yuko; Shingu, Masahisa; Fujimoto, T; Kondo, Masaharu; Yamamoto, Shigeru; Tominaga, Kaoru; Sasaguri, Yasuyuki

doi:10.1016/s0140-6736(83)90921-2

Cited by 73 publications

(32 citation statements)

References 14 publications

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“…Several investigations of the serology of MCLS revealed a significant rise in the level of serum antibodies against some compounds and agents [3,8,10,17,20,25,27]. These reports suggest that the several kinds of antibody are the products of polyclonal B-cell activation.…”

Section: Discussionmentioning

confidence: 99%

“…P. acnes (Kato) [17], kindly provided by Prof. Kato, Kurume University School of Medicine, was inoculated into C57BL/6J mice intraperitoneally at the rate of 3 x 108 per mouse. Two days after the inoculation, the mice were sacrificed and the liver was prepared for IF studies.…”

Section: Methodsmentioning

confidence: 99%

“…Propionibacterium aches [17] and mite [3,8,10]. Recently, aberrant regulatory T-and B-cell functions were associated with the initiation of such antibody production [22,23], although Shannon et al [26] reported no abnormalities in the distribution of lymphocyte subsets in cases with MCLS.…”

Section: Introductionmentioning

confidence: 99%

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Possible polyclonal B cell activation in mucocutaneous lymph node syndrome

1986

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Immunoserological studies on polyclonal B cell activation were carried out on 39 patients with mucocutaneous lymph node syndrome (MCLS) and in age-matched healthy individuals. The incidence of anti-mite, P. acnes (Kato) and EB virus antibodies, recently proposed as aetiological agents by some investigators, was increased in the patient group. Serum immunoglobulin (Ig) M level and IgM-anti-dinitrophenyl (DNP) antibodies, which are considered to be parameters of polyclonal B cell activation, were determined in MCLS cases. The level of serum IgM in MCLS was significantly elevated (0.02 less than P less than 0.05). Levels of anti-DNP antibodies in seven cases of MCLS (18%) were significantly higher than those of the controls (P less than 0.01). Nine of the ten pair sera in MCLS showed a stage-dependent decrease in anti-DNP antibodies. These results suggest that polyclonal B cell activation occurs in MCLS.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Possible polyclonal B cell activation in mucocutaneous lymph node syndrome

1986

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“…The method used for isolation and typing of P, acnes has been described previously by Kato et al (1983). After initial isolation, the P. acnes strains were preserved in cooked meat broth at room temperature.…”

Section: Microorganismsmentioning

confidence: 99%

“…Since 1983, we have studied Propionibacterium acnes (P. acnes) isolated from cervical lymph node biopsy specimens and blood samples of patients with Kawasaki disease (Kato et al 1983;Kato et al 1985). It has been suggested that P. acnes may be involved in the pathogenesis of this disease for the following reasons.…”

Section: Introductionmentioning

confidence: 99%