Variante en CAPN10 y factores ambientales muestran evidencia de asociación con exceso de peso en jóvenes de Medellín, Colombia

Abstract

participated in the study design, the fieldwork, the genetic and environmental information analysis and the writing of the article. Rosa M. Uscátegui conducted the anthropometric component of the study. María V. Parra conducted the genetic component. Introduction: Obesity results from interaction between genetic and environmental risk factors. Objective: To evaluate the effect of three gene variants and environmental factors on obesity and overweight in young people aged 10 to 18 years in a Colombian population. Materials and methods:A total of 424 subjects were selected and separated into three groups for a cross-sectional study; 100 obese and 112 overweight subjects were matched with 212 normal-weight controls. Associations were evaluated between excess weight and three genetic polymorphisms (UCP3-rs1800849, FTO-rs17817449, and CAPN10-rs3842570), as well as the family history, the time spent watching television and playing video games, and the diet. Results: A family history of obesity, the time spent watching television and playing video games, the lack of breastfeeding, a low consumption of cereals, legumes, fruits, vegetables, and a high consumption of fast foods were characteristics typically found in obese individuals compared to controls. A significant association between genotype I/I (SNP19 of CAPN10) and excess weight was found even with an active lifestyle. In addition, significant associations between the C/C genotype of the UCP3 gene and the G/G and T/T genotypes of the FTO gene and excess weight were found only in young sedentary individuals. Conclusions:In this population, inadequate diet and sedentary lifestyle increased the risk of excess weight. Genotype I/I of SNP19 in CAPN10 was significantly associated with excess weight. In contrast, FTO and UCP3 variants exhibited effects only in sedentary environments.

Association of CAPN10 gene (rs3842570) polymorphism with the type 2 diabetes mellitus among the population of Noakhali region in Bangladesh: a case-control study

“…Association of CAPN10 SNP-19 with T2DM has been observed in several ethnic groups such as Mexican Mestizos [ 31 ], south Indians [ 33 ], Javanese [ 34 ], Koreans [ 35 ], Egyptians [ 30 ], Tunisian Arabs [ 19 ], and Spanish [ 36 ]. It is also evident that SNP-19 is associated with several metabolic traits such as obesity [ 19 , 32 , 37 - 41 ], high total cholesterol (TC) [ 29 , 30 , 42 ], high triglycerides (TG) [ 37 , 43 ], systolic blood pressure (SBP), and diastolic blood pressure (DBP) [ 35 ] in T2DM patients.…”