Variantes de escape del virus de la hepatitis B

Jaramillo, Carlos Mario Zapata; Navas, María Cristina

doi:10.4067/s0716-10182015000300008

Cited by 10 publications

(7 citation statements)

References 48 publications

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“…T140I was also described in Chinese chronic carriers of HBV with concurrent HBsAg and anti‐HBs [Ding et al, ]. Immunized children born to HBsAg‐positive mothers also harbored this amino acid change [Hsu et al, ; Hsu et al, ; Jaramillo and Navas, ] as well as chronic carriers of HBV with cirrhosis or hepatocellular carcinoma [Yamani et al, ], carriers of occult hepatitis B [Huang et al, ; Lazarevic, ], and HBV carriers who did not receive the vaccine or HBIG [Komatsu et al, ].…”

Section: Discussionmentioning

confidence: 99%

Mutation in the S gene a determinant of the hepatitis B virus associated with concomitant HBsAg and anti‐HBs in a population in Northeastern Brazil

Albuquerque

Sousa

Santos

et al. 2016

Journal of Medical Virology

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Mutations in the a determinant of S gene may develop co-existence of hepatitis B surface antigen (HBsAg) and antibodies to HBsAg (anti-HBs) in the serum of infected hepatitis B virus (HBV) individuals. Mutations in this region may change the antigenicity of HBsAg, which in turn, lead to escape of neutralizing action of anti-HBs antibodies. This study identified individuals with concomitant HBsAg and anti-HBs serological markers in individuals of Maranhão, Northeastern Brazil. Samples from a population-based study were evaluated for HBsAg, anti-HBs, and anti-HBc, and those that tested positive for simultaneous HBsAg and anti-HBs were submitted to HBV DNA quantification and S gene characterization by Sanger sequencing. Mutations were investigated in the a determinant located in major hydrophilic region (MHR) of the S gene. Among 3,984 samples analyzed, 92 (2.3%) were positive for HBsAg and three had the atypical HBsAg and anti-HBs-positive profile (3.26%). The frequency of HBsAg and anti-HBs co-existence was similar to previous studies. Only one individual harbored mutation in the S gene a determinant associated with this profile. Little is known about this phenomenon; however, studies as ours may contribute for future enlightenment of this important issue. J. Med. Virol. 89:458-462, 2017. © 2016 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Mutation in the S gene a determinant of the hepatitis B virus associated with concomitant HBsAg and anti‐HBs in a population in Northeastern Brazil

Albuquerque

Sousa

Santos

et al. 2016

Journal of Medical Virology

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“…92% of the countries in the world have implemented this vaccine with a global coverage of 69%. Antibodies produced in response to the vaccine are directed against the HBsAg "a" determinant, but despite the availability of an effective vaccine, hepatitis B remains a global public health problem [19]. Mutant strains are scarcely or non-neutralized by anti-HBs antibodies, acquiring a clear biological advantage over the wild strain that originated them: they have the possibility of replicating in the host from which they arise and in presumably immunocompetent vaccinated individuals [2].…”

Section: Mutations In the Viral Dna Genes Of The Hbv Virusmentioning

confidence: 99%

Problems with the variants or quasi-species of the Hepatitis B virus (HBV) in treatment

Rodríguez¹,

Hernández²,

Rodríguez³

et al. 2021

Magna Sci. Adv. Biol. Pharm.

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The HBV genome has a very high mutation rate, which is why it is considered a highly variable virus, being able to produce different variants or quasi-species in the same host, differentiated by small mutations that favor the oncogenic potential of the virus, in addition to attenuating the immunogenicity and antigenicity. There are a large number of epidemiological findings and studies that suggest a relationship between genotypes and pre-core / core variants of the hepatitis B virus with the clinical course of infection and the response to different antiviral treatments.

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“…Adicionalmente, otros marcadores serológicos y virológicos como detección de anticuerpos contra la proteína core del VHB tipo inmunoglubulina M (antiHBcIgM) e inmunoglobulina G (anti-HBcIgG), anti-HBs (anticuerpos contra el HBsAg), antígeno e (HBeAg, del inglés hepatitis B e Antigen), ADN viral (carga viral) y niveles elevados de aminotransferasas (ALTs) son importantes para la clasificación del tipo de infección (2,4,5).…”

Section: Introductionunclassified

“…Debido a la persistencia del genoma del VHB en los hepatocitos, actualmente se considera que el marcadoranti-HBs no es marcador del aclaramiento viral. Por lo anterior individuos con resolución clínica pueden eventualmente desarrollar infección crónica (4,5).…”

Section: Introductionunclassified

“…La infección crónica por el VHB es, sin embargo, un proceso dinámico con un amplio espectro de afectaciones, en un extremo se encuentra el paciente con el antígeno HBsAg positivo asintomático detectado accidentalmente (IDAHS), sin evidencia clínica de enfermedad hepática y en el otro extremo se tiene la cirrosis en los estadios finales de la infección y el carcinoma hepatocelular (HCC) (3)(4)(5)(6)(7)(8).…”

Section: Introductionunclassified

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