“…It is not surprising that most of the signature genes have been reported to be related with prostate cancer. For instance, AMACR [ 54 – 59 ], HPN [ 60 – 62 ], SOX4 [ 63 – 67 ], DAXX [ 68 , 69 ], EPB41L3 [ 70 – 72 ], CXCR3 [ 73 – 79 ], TGFB3 [ 80 , 81 ], EEF2 [ 82 , 83 ] are the most well-known biomarkers for prostate cancer. As defined by the Gene Ontology Consortium, most of the resulted genes are involved in cell cycle (MYH11), regulation of transcription (SOX4, SMARCC2, ZIM2, PDLIM5, ZNF217, PSIPI, ACRC, PEG3, TAF1, ZMYM3), receptor activity (JAM3, TAPBP, COL4A5, CXCR3, COL4A6, HPN, COL9A2, PTPRN2, COL6A1) and other biological activities like transportation, cell adhesion and cell organisation (the list of genes with the related literature references can be found in S8 Table ).…”