2012
DOI: 10.1038/pcan.2012.17
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Variants in the HEPSIN gene are associated with susceptibility to prostate cancer

Abstract: BACKGROUND: HEPSIN (HPN) gene is one of the most consistently overexpressed genes in patients with prostate cancer; furthermore, there is some evidence supporting an association between HPN gene variants and the risk of developing prostate cancer. In this study, sequence variants in the HPN gene were investigated to determine whether they were associated with prostate cancer risk in a Korean study cohort. METHODS: We evaluated the association of 17 single-nucleotide polymorphisms (SNPs) in the HPN gene with pr… Show more

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Cited by 13 publications
(10 citation statements)
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“…HPN , which encodes the cell surface serine protease hepsin, is one of the most consistently overexpressed genes for prostate cancer, and hepsin protein expression is associated with the growth and progression of cancers, particularly prostate cancer [40] . In addition, some polymorphisms in the HPN gene might also be associated with the risk of developing prostate cancer [41] . The protein encoded by SLC25A6 is a member of the mitochondrial ADP/ATP carrier subfamily of solute carrier protein genes.…”
Section: Resultsmentioning
confidence: 99%
“…HPN , which encodes the cell surface serine protease hepsin, is one of the most consistently overexpressed genes for prostate cancer, and hepsin protein expression is associated with the growth and progression of cancers, particularly prostate cancer [40] . In addition, some polymorphisms in the HPN gene might also be associated with the risk of developing prostate cancer [41] . The protein encoded by SLC25A6 is a member of the mitochondrial ADP/ATP carrier subfamily of solute carrier protein genes.…”
Section: Resultsmentioning
confidence: 99%
“…The research has proved that expression of the encoded protein of HPN is related to the growth and progression of cancers, particularly prostate cancer. It may be associated with susceptibility to prostate cancer 21 . The MTHFD2 in GSE21050 is seen as a prognostic factor and a potential therapeutic target for future cancer treatments.…”
Section: Resultsmentioning
confidence: 99%
“…It is not surprising that most of the signature genes have been reported to be related with prostate cancer. For instance, AMACR [ 54 59 ], HPN [ 60 62 ], SOX4 [ 63 67 ], DAXX [ 68 , 69 ], EPB41L3 [ 70 72 ], CXCR3 [ 73 79 ], TGFB3 [ 80 , 81 ], EEF2 [ 82 , 83 ] are the most well-known biomarkers for prostate cancer. As defined by the Gene Ontology Consortium, most of the resulted genes are involved in cell cycle (MYH11), regulation of transcription (SOX4, SMARCC2, ZIM2, PDLIM5, ZNF217, PSIPI, ACRC, PEG3, TAF1, ZMYM3), receptor activity (JAM3, TAPBP, COL4A5, CXCR3, COL4A6, HPN, COL9A2, PTPRN2, COL6A1) and other biological activities like transportation, cell adhesion and cell organisation (the list of genes with the related literature references can be found in S8 Table ).…”
Section: Discussionmentioning
confidence: 99%