Variants of Cardiomyopathy and Hypertension in Neuroblastoma

Kwok, Sylvia Y. C. L.; Cheng, Frankie Wai Tsoi; Lo, A. F.C.; Yam, Man Ching; Li, Chi Kong

doi:10.1097/mph.0b013e318290c628

Cited by 24 publications

(24 citation statements)

References 16 publications

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“…Few studies have focused on the perioperative management of HT, and most of these have been case reports [1][2][3][4][5][6][7][8][9]. Both cardiac and neurological complications of HT have been described [10].…”

Section: Abstract a R T I C L E I N F Omentioning

confidence: 99%

Perioperative management of hypertensive neuroblastoma: A study from the Italian Group of Pediatric Surgical Oncologists (GICOP)

Pio

Avanzini

Mattioli

et al. 2017

Journal of Pediatric Surgery

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Background: Hypertension (HT) is rarely reported in patients affected by Neuroblastoma (NB), and management guidelines are lacking. Clinical features and perioperative medical treatment in such patients were reviewed to 1) ascertain whether a shared treatment strategy exists among centers and 2) if possible, propose some recommendations for the perioperative management of HT in NB patients. Methods: A retrospective multicenter survey was conducted on patients affected by NB who presented HT symptoms. Results: From 2006 to 2014, 1126 children were registered in the Italian Registry of Neuroblastoma (RINB). Of these, 21 with HT (1.8%) were included in our analysis. Pre-and intraoperative HT management was somewhat dissimilar among the participating centers, apart from a certain consistency in the intraoperative use of the alpha-1 blocker urapidil. Six of the 21 patients (28%) needed persistent antihypertensive treatment at a median follow-up of 36 months (range 4-96 months) despite tumor removal. Involvement of the renal pedicle was the only risk factor constantly associated to HT persistency following surgery. A correlation between the presence of HT and the secretion of specific catecholamines and/or compression of the renal vascular pedicle could not be demonstrated.

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Section: Abstract a R T I C L E I N F Omentioning

confidence: 99%

Perioperative management of hypertensive neuroblastoma: A study from the Italian Group of Pediatric Surgical Oncologists (GICOP)

Pio

Avanzini

Mattioli

et al. 2017

Journal of Pediatric Surgery

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“…Kwok et al, in their study of neuroblastoma and its myriad cardiac-related presentations, reported DCM to be the commonest cardiac abnormality and attributed elevated catecholamines to the same cause. 8 They suggested catecholamine-induced vasoconstriction, coronary vasospasm, tachycardiomyopathy caused by a hyper-adrenergic state and down-regulation of beta-adrenergic receptors as factors for cardiac muscle damage and subsequent DCM. Interestingly, they found that not all children with neuroblastoma and DCM had hypertension but invariably all of them had elevated urinary catecholamine levels.…”

Section: Discussionmentioning

confidence: 99%

Dilated cardiomyopathy in a child with abdominal neuroblastoma and normal serum catecholamine levels: anaesthetic management and review of literature

Ganigara

Ramavakoda

Srinivasan

et al. 2017

Southern African Journal of Anaesthesia and Analgesia

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Neuroblastoma is the most common extracranial solid tumour of childhood. Dilated cardiomyopathy as an initial presentation of neuroblastoma is rare. We report the case of a three-year-old child with giant abdominal neuroblastoma encasing the abdominal aorta who presented with dilated cardiomyopathy in heart failure without hypertension or elevated serum catecholamine levels. The probable pathophysiological mechanism for such an occurrence and review of similar cases along with perioperative management is presented.

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“…8 Seizures and autonomic dysfunction are not a part of opsoclonus-myoclonus syndrome, although hypertension can be rarely associated if there is an underlying neuroblastoma. 21 Opsoclonus-myoclonus syndrome has been associated with NMDAR encephalitis in case reports; so, its presence does not preclude the diagnosis of NMDAR encephalitis. 22,23 Limbic encephalitis hallmark sign is impairment of memory and also presents with confusion, irritability, depression, and seizures.…”

Section: Diagnosismentioning

confidence: 97%