Variants of NOS1, NOS2, and NOS3 Genes in Asthmatics

Gao, P. S.; Kawada, H.; Kasamatsu, Teresa S.; Mao, Xq-Q.; Roberts, Mary Flynn; Miyamoto, Yoshihiro; Yoshimura, Michihiro; Saitoh, Yoshimoto; Yasue, Hirofumi; Nakao, Kazuwa; Adra, Cn N.; Kun, J.; Morooka, Shigenori; Inoko, Hidetoshi; Ho, LP; Shirakawa, Taro; Hopkin, J. M.

doi:10.1006/bbrc.1999.2030

Cited by 72 publications

(51 citation statements)

References 22 publications

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“…Another study also describing the association of this polymorphism with asthma was carried out in the British population (Gao et al 2000a). The 16-repeat allele of NOS1 is a protective allele against asthma development in both British and Japanese populations, suggesting that this allele represents an old protective haplotype that evoked before the division of races.…”

Section: Discussionmentioning

confidence: 99%

“…Primers for the NOS1 intron 2 GT repeat were as described previously (Gao et al 2000a). One of the primers, 5'-ATA-GAGCCTGTGCTGAGCCTTC, was 6-FAM labeled.…”

Section: Families and Individualsmentioning

confidence: 99%

“…Instead, a GT repeat polymorphism in exon 1 was associated with eosinophil count in the German/Swedish study and with allergic diseases in the Japanese study. A dinucleotide repeat marker in NOS1 was also reported to be associated with the disease in the British population (Gao et al 2000a). An association between a SNP in NOS1 and eosinophil count was also shown in German/ Swedish patients (Immervoll et al 2001).…”

Section: Introductionmentioning

confidence: 99%

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Linkage and association of childhood asthma with the chromosome 12 genes

et al. 2004

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Several studies have shown linkage of chromosome region 12q13-24 to bronchial asthma and related phenotypes in ethnically diverse populations. In the Japanese population, a genome-wide study failed to show strong evidence of linkage of this region. Chromosome 12 genes that showed association with the disease in at least one report include: the signal transducer and activator of transcription 6 gene (STAT6), the nitrogen oxide synthetase 1 gene (NOS1), the interferon c gene (IFNG), and the activation-induced cytidine deaminase gene (AICDA). To evaluate the linkage between chromosome 12 and childhood asthma in the Japanese population, we performed sib-pair linkage analysis on childhood asthma families using 18 microsatellite markers on chromosome 12. To investigate association between chromosome 12 candidate genes and asthma, distributions of alleles and genotypes of repeat polymorphisms of STAT6, NOS1, and IFNG were compared between controls and patients. Single nucleotide polymorphism of AICDA was also investigated. Chromosome region 12q24.23-q24.33 showed suggestive linkage to asthma. The NOS1 intron 2 GT repeat and STAT6 exon 1 GT repeat were associated with asthma. Neither the IFNG intron 1 CA repeat nor 465C/T of AICDA showed any association with asthma. Our results suggest that NOS1 and STAT6 are asthmasusceptibility genes and that chromosome region 12q24.23-q24.33 contains other susceptibility gene(s).

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Section: Discussionmentioning

confidence: 99%

“…Primers for the NOS1 intron 2 GT repeat were as described previously (Gao et al 2000a). One of the primers, 5'-ATA-GAGCCTGTGCTGAGCCTTC, was 6-FAM labeled.…”

Section: Families and Individualsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Linkage and association of childhood asthma with the chromosome 12 genes

et al. 2004

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“…Allelic associations have been found for both a (CA) n repeat polymorphism and a bi-allelic marker in exon 29 of NOS1 in Caucasian Americans [39,40]. In a British adult asthma population a significant association was found for a polymorphism in intron 2 of NOS1, but not for markers in the NOS2 and NOS3 genes [41], and data from mouse models indicate that NOS1 contributes substantially to FENO [42,43]. In humans, a study involving mild asthma patients revealed that the size of an (AAT) n repeat polymorphism in intron 20 of NOS1 was significantly associated with FENO [44].…”

Section: Genetics Of the Neuronal Nitric Oxide Synthase Pathway In Asmentioning

confidence: 99%

Measurement of exhaled nitric oxide in children, 2001

Baraldi¹,

Jongste²,

Gaston³

et al. 2002

Eur Respir J

288

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Measurement of fractional exhaled nitric oxide in exhaled air is an exciting innovative technique that gives new insights in to the pathophysiology of lung disease and asthma in particular, with many potential clinical applications. Careful standardisation of measurement techniques will facilitate the use of this new measurement in paediatric respiratory medicine; this Task Force was set up for this purpose. Methodologies, for use in all age groups, are already available and there are abundant questions relating to interpretation and application of fractional exhaled nitric oxide waiting to be addressed. Noninvasiveness and instantaneous results potentially make it a suitable monitoring instrument for use in children. Exhaled nitric oxide measurement has definitely found its way into clinical research in paediatric respiratory medicine. Evidence for clinically-useful applications is accumulating, and the merits of this new technique must now be demonstrated in larger studies, using standardised methodology in an appropriate setting.

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“…Konno et al 20 suggested that the 14-repeat allele of CCTTT promoter polymorphism that affects promoter activity is inversely associated with atopy, but not with asthma. Gao et al 21 found no association of a biallelic repeat with asthma. The…”

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confidence: 97%