2005
DOI: 10.1200/jco.2005.02.6534
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Variates of Survival in Metastatic Uveal Melanoma

Abstract: A substantial subset of patients with metastatic uveal melanoma survive more than 4 years with metastatic disease. Data on variates of survival and site of first metastasis may guide strategies for screening patients, although our data failed to show a survival advantage in discovering asymptomatic metastatic disease.

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Cited by 272 publications
(244 citation statements)
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“…[1][2][3] When liver metastases develop, the prognosis is poor and life expectancy reduces to less than 6 months in the absence of treatment. 4 No adjuvant therapy has proven efficacy for the prevention of metastases following ocular treatment and only minimal improvements in disease-free survival have been observed with intra-arterial chemotherapy.…”
Section: Introductionmentioning
confidence: 99%
“…[1][2][3] When liver metastases develop, the prognosis is poor and life expectancy reduces to less than 6 months in the absence of treatment. 4 No adjuvant therapy has proven efficacy for the prevention of metastases following ocular treatment and only minimal improvements in disease-free survival have been observed with intra-arterial chemotherapy.…”
Section: Introductionmentioning
confidence: 99%
“…About half of the UM patients eventually develop hematogenous metastasis, with liver metastasis being the most common form. Without proper treatment, most patients with metastasis will die within a short period of time (6−8 months) (216). According to the Collaborative Ocular Melanoma Study (COMS), a large multicenter study participated by 43 clinical ophthalmic centers in North America, the median survival was only 3.6 months among UM patients with confirmed metastasis, and the 5-year cumulative survival rate was only 1% (217).…”
Section: Biological Characteristicsmentioning
confidence: 99%
“…The natural history of uveal melanoma is characterized by the frequent development of metastases, with over 50% of patients developing metastatic disease at any time from the initial diagnosis of the primary to several decades later (2,(16)(17)(18)(19)(20)(21). A broad spectrum of therapies, including systemic therapies (22), hepatic artery infusion of chemotherapy, hepatic embolization, and metastastectomy, have been used to treat patients with metastatic uveal melanoma.…”
Section: Introductionmentioning
confidence: 99%