Variation Analysis of SARS-CoV-2 Complete Sequences from Iran

Abstract

Aim: SARS-CoV-2 is an emerging coronavirus that was discovered in China and rapidly spread throughout the world. The authors looked at nucleotide and amino acid variations in SARS-CoV-2 genomes, as well as phylogenetic and evolutionary events in viral genomes, in Iran. Materials & methods: All SARS-CoV-2 sequences that were publicly released between the start of the pandemic and 15 October 2021 were included. Results: The majority of mutations were found in vaccine target proteins, Spike and Nucleocapsid proteins, and nonstructural proteins. The majority of the viruses that circulated in the early stages of the pandemic belonged to the B.4 lineage. Conclusion: We discovered the prevalence of viral populations in Iran. As a result, tracking the virus’s variation in Iran and comparing it with a variety of nearby neighborhoods may reveal a pattern for future variant introductions.

Interaction of toll-like receptors and ACE-2 with different variants of SARS-CoV-2: A computational analysis

“…A previous study has shown that this mutation appeared in Iran in May 2020. 50 Of the eight Iranian isolates studied, all have more than one RBD mutation, and the interaction of these mutations could affect binding to the ACE2 receptor. According to the docking results, the effect of the RBD mutations was not consistent with previous studies in some cases.…”