Variation and significance of serum leptin, blood lipid level, adiponectin, NO and TNF-α for patients with non-traumatic ischemic necrosis of the femoral head

Xu, Bing; Hu, Qionghua; Zhao, Bo; Zhou, Zongke

doi:10.1016/j.sjbs.2017.11.008

Cited by 6 publications

(5 citation statements)

References 2 publications

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“…One month after embolization, the myometrium had almost no lysis and necrosis of myometrial smooth muscle cells, suggesting that the MSAH did not affect the blood flow of peripheral blood vessels and did not cause tissue ischemia and necrosis. It has been reported (Prieto-Moure et al, 2017;Xu et al, 2017) that tissue cells produce and release TNF-α after tissue ischemia to activate T cells, promote the production and secretion of IL-1β, and induce inflammation. In this study, we found that the levels of TNF-α and IL-1β both in the plasma and uterine tissue were significantly lower in the MSAH group than in the Gelfoam group and the Coil group, suggesting that MSAH can induce a slight inflammatory reaction and does not cause the peripheral tissue necrosis.…”

Section: Discussionmentioning

confidence: 99%

Application of modified sodium alginate hydrogel for interventional embolization of hemorrhagic diseases

Wei,

Deng,

et al. 2024

Front. Mater.

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Traditional particulate embolic agents are small in diameter, but can easily embolize the ends of blood vessels, resulting in ischemia and necrosis of normal tissues and organs. The metal spring embolic agent has a larger diameter, but it cannot be degraded and can easily cause permanent damage to blood vessels. Ideally, a bleeding embolism should achieve rapid hemostasis without causing long-term necrosis of organs and tissues. In this study, a modified sodium alginate hydrogel (MSAH) was prepared by mixing an oxidized sodium alginate (OSA) aqueous solution with a carboxymethyl chitosan (CMC) aqueous solution at a ratio of 1:6 in a 38°C bath for 8 min. The feasibility of this modified hydrogel was then tested in an internal iliac artery hemorrhage model using New Zealand rabbits. The MSAH had good adhesion. The hydrogel was injected through a single curved 4F catheter without obvious effects on uterine smooth muscle cell proliferation and apoptosis. The blood flow of the internal iliac artery was restored by long-term degradation of the sodium alginate hydrogel, and no ischemia and necrosis were observed by histopathology. The MSAH prepared using a mixture of OSA and CMC had good adhesion, biocompatibility, and injectability and could be used for target-vessel embolization in an internal iliac artery hemorrhage model. The MSAH can achieve main artery embolization without affecting the peripheral artery blood supply, resulting in both short-term rapid hemostasis and long-term degradation, with no target organ necrosis.

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Section: Discussionmentioning

confidence: 99%

Application of modified sodium alginate hydrogel for interventional embolization of hemorrhagic diseases

Wei,

Deng,

et al. 2024

Front. Mater.

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“…Regarding the correlation between obesity and ONFH, it is important to include additional factors such as hyperlipidemia. However, further investigation is required to confirm this relationship [ 23 – 25 ].…”

Section: Discussionmentioning

confidence: 99%

Laboratory indices in patients with osteonecrosis of the femoral head: a retrospective comparative study

Zheng,

Ye,

Huang

et al. 2023

J Orthop Surg Res

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Background Osteonecrosis of the femoral head is a degenerative condition linked to corticosteroids, alcoholism, or trauma. With its rising prevalence due to increased hormone drug use and its debilitating effects on young to middle-aged individuals, understanding its association with specific laboratory indicators can aid early diagnosis and prevention. Methods Upon retrospective analysis of the clinical data pertaining to individuals diagnosed with femoral head necrosis, spanning from January 2016 to January 2022, a comprehensive evaluation was conducted within the same time frame. The study aimed to ascertain the presence of femoral head necrosis in a total of 1176 individuals. A total of 1036 healthy patients were recruited randomly, ensuring that their ages matched. The risk variables associated with the utilization of logistic regression analysis and analysis techniques are employed. The patient examines the age distribution within a specific age group. Results The levels of high-density lipoprotein, low-density lipoprotein A1, lipoprotein B1, total protein, albumin, globulin, and other lipophilic metabolism and coagulation markers exhibited a statistically significant increase compared to the control group. A multifactor logistic regression analysis was conducted to identify potential risk factors associated with femoral head necrosis in patients. Conclusion Femoral head necrosis is associated with a range of variables including coagulation malfunction, lipid metabolic abnormalities, and inflammation.

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“…ADPN and LEP, which are mainly secreted by adipose tissue, may provide a bridge between energy and bone metabolism by mediating the balance of bone mass and fat content . We observed similar increases in ADPN levels and decreases in LEP levels following GC therapy in both groups (Fig.…”

Section: Discussionmentioning

confidence: 99%

Serum Biomarkers Related to Glucocorticoid‐Induced Osteonecrosis of the Femoral Head: A Prospective Nested Case‐Control Study

Wang

Hua

Chang

et al. 2019

Journal Orthopaedic Research

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Early diagnosis and prevention of glucocorticoid (GC)‐induced osteonecrosis of the femoral head (ONFH) continues to be a challenging problem for clinicians and researchers. However, the role of circulating biomarkers for GC‐induced ONFH, which may reveal individual susceptibility and facilitate earlier diagnosis, remains to be determined. The aim of this study was to identify potential biomarkers that may predict early GC‐induced ONFH. A total of 123 patients scheduled for initial systemic GC therapy were enrolled in this prospective nested case–control study. The serum concentrations of 13 potential biomarkers were measured in seven patients with GC‐induced ONFH, diagnosed instantly after short‐term use of GCs and in 20 controls who did not develop osteonecrosis despite similar GC therapy. Biomarkers were measured both before and after taking GCs to identify any differences in marker levels and the changes during GC therapy between two groups. Type I collagen cross‐linked C‐telopeptide (β‐CTX; p = 0.000) was significantly lower, high‐density lipoprotein cholesterol (p = 0.092) and apolipoprotein (apo)‐B/apo‐A1 (p = 0.085) tended to be lower and higher, respectively, before GC treatment in osteonecrosis group. After GC therapy, β‐CTX (p = 0.014) was significantly lower and amino terminal telopeptide of procollagen type I (PINP; p = 0.068) tended to be lower in the osteonecrosis group. As secondary outcomes, we observed remarkable changes in nine potential biomarkers following short‐term GC therapy in both groups. In conclusion, we found that β‐CTX, could potentially be used to predict GC‐induced ONFH before GC therapy. Lower β‐CTX and PINP are promising biomarkers for the early diagnosis of GC‐induced ONFH. These findings need to be confirmed in large‐scale prospective studies. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:2348–2357, 2019

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Variation and significance of serum leptin, blood lipid level, adiponectin, NO and TNF-α for patients with non-traumatic ischemic necrosis of the femoral head

Cited by 6 publications

References 2 publications

Application of modified sodium alginate hydrogel for interventional embolization of hemorrhagic diseases

Application of modified sodium alginate hydrogel for interventional embolization of hemorrhagic diseases

Laboratory indices in patients with osteonecrosis of the femoral head: a retrospective comparative study

Serum Biomarkers Related to Glucocorticoid‐Induced Osteonecrosis of the Femoral Head: A Prospective Nested Case‐Control Study

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