Variation de la captation hépatique de 18-FDG dans l’évaluation intermédiaire des lymphomes B diffus à grandes cellules en TEP/TDM

Gordien, Pierre; Morlière, Camille; Bordenave, Laurence; Hindié, Elif

doi:10.1016/j.mednuc.2014.01.004

Cited by 3 publications

(1 citation statement)

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“…However, a recent study found an excellent inter-observer agreement and no significant difference whether the VOI is placed in the upper part, the portal level, or at the bottom of the right liver lobe [ 23 ]. Our results are also in agreement with those of Grohien et al [ 24 ], who showed a larger dispersion of values and a higher variance for hepatic SUV max compared to hepatic SUV average .…”

Section: Discussionsupporting

confidence: 94%

For avid glucose tumors, the SUV peak is the most reliable parameter for [18F]FDG-PET/CT quantification, regardless of acquisition time

et al. 2016

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BackgroundThis study is an assessment of the impact of acquisition times on SUV with [18F]FDG-PET/CT on healthy livers (reference organ with stable uptake over time) and on tumors.MethodsOne hundred six [18F]FDG-PET/CT were acquired in list mode over a single-bed position (livers (n = 48) or on tumors (n = 58)). Six independent datasets of different durations were reconstructed (from 1.5 to 10 min). SUVmax (hottest voxel), SUVpeak (maximum average SUV within a 1-cm3 spherical volume), and SUVaverage were measured within a 3-cm-diameter volume of interest (VOI) in the right lobe of the liver. For [18F]FDG avid tumors (SUVmax ≥ 5), the SUVmax, SUVpeak, and SUV41% (isocontour threshold method) were computed.ResultsFor tumors, SUVpeak values did not vary with acquisition time. SUVmax displayed significant differences between 1.5- and 5–10-min reconstruction times. SUV41% was the most time-dependent parameter. For the liver, the SUVaverage was the sole parameter that did not vary over time.ConclusionsFor [18F]FDG avid tumors, with short acquisition times, i.e., with new generations of PET systems, the SUVpeak may be more robust than the SUVmax. The SUVaverage over a 3-cm-diameter VOI in the right lobe of the liver appears to be a good method for a robust and reproducible assessment of the hepatic metabolism.

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Section: Discussionsupporting

confidence: 94%