Variation, diurnal and over longer periods of time, in blood haemoglobin, haematocrit, plasma protein, erythrocyte sedimentation rate, and blood chloride

Abstract

Although the composition of blood is assumed to be constant within narrow limits, fluctuations in concentration of its constituents have been found by many observers over the period of a day or longer. Shaw (1927), Jores (1934) and others describe daily fluctuations in the white corpuscles, and Sabin et al. (1925) found similar changes in the blood platelets.The literature dealing with diurnal fluctuations in the red blood corpuscles (R.B.C.) is already large and has been recently reviewed by Branwood (1946). Changes over longer periods of time have been described by Platt & Freeman (1930) In the present study an attempt is made to determine whether a true diurnal rhythm (significant diurnal variation) is present for blood haemoglobin concentration (Hb), haematocrit value, plasma protein concentration, erythrocyte sedimentation rate (E.S.R.), and blood chloride concentration. Data are also presented to show variation over longer periods of time. Much of the material was not considered suitable for statistical analysis, and the data offered is mainly that dealing with repeated assays on the same individual (intra-individual variability), and with groups studied on the same day (group variability). A small amount of data obtained from sick individuals and from a few animals is given for comparison.

Interaction effects of time of day and sub-maximal treadmill exercise on the main determinants of blood fluidity

“…As with pre-exercise conditions, fibrinogen, albumin and total protein were resistant to biorhythmic influences during sub-maximal endurance exercise. These data are consistent with earlier reports [26], in which suggested that significant changes in plasma proteins are absent during normal waking hours of 07:00 to 10:00. In addition to baseline values, the plasma protein responses to sub-maximal exercise were not affected by time of day.…”

Weekly and 90-Minute Biological Variations in Cardiac Troponin T and Cardiac Troponin I in Hemodialysis Patients and Healthy Controls

“…A definite trend was not found in hs-cTnI in healthy individuals, possibly because CVa in this group was much higher than the biological variation. Diurnal variation is indeed a common finding for many biological constituents (39,40 ), and we assume that the declining values seen in the current study represent a part (i.e., 6 h) of the diurnal variation of hs-cTn. In principle, the calculated RCV found in our study is valid only between 08:30 and 14:30, because the magnitude and direction of diurnal variation assumed during the 24-h cycle is unknown.…”

Trends in hospitalizations of patients with acute coronary syndrome and indicators of the atmospheric state in Moscow in 2009-2012

“…Спазм коронарных артерий ведет к сни-жению толерантности к физическим нагрузкам, провоци-рует ангинозные боли и может привести к разрыву атеро-склеротических бляшек, образованию нестабильных бля-шек с последующим развитием тромбоза. По данным лите-ратуры, в холодное время года у здоровых людей и пациен-тов с заболеваниями сосудов отмечена гемоконцентрация [24][25][26][27][28][29], повышение уровня прокоагулянтов и маркеров активации гемостаза (фактор свертывания крови VIII [30], фактор Виллебранда [30], фибриноген [23,24,30], D-димер [31], маркеров воспалительной реакции (СОЭ [20,28], C-реактивный белок [31,23], ИЛ-1,ИЛ-6 [23]), снижение концентрации прокоагулянтов (протеин С [24]), антиокси-дантов (витамин D [29]). …”