Variation in clinical vitamin D status by DiaSorin Liaison and LC-MS/MS in the presence of elevated 25-OH vitamin D2

Koning, Lawrence de; Al-Turkmani, M. Rabie; Berg, Anders H.; Shkreta, Aida; Law, Terence; Kellogg, Mark D.

doi:10.1016/j.cca.2012.09.002

Cited by 38 publications

(22 citation statements)

References 15 publications

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“…Moreover, the vitamin D status may be higher than detected, as we used the DiaSorin Liaison chemiluminescence immunoassay, similar to most previous epidemiological studies [2, 6, 15, 21, 22]. It is known that this method underestimates vitamin D status compared to liquid chromatography tandem mass spectrometry (LC-MS/MS) [34], which has been suggested to be one of the most accurate methods [35]. …”

Section: Discussionmentioning

confidence: 99%

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Breastfeeding woman are at higher risk of vitamin D deficiency than non-breastfeeding women - insights from the German VitaMinFemin study

2016

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BackgroundDespite increased awareness of the adverse health effects of vitamin D deficiency, only a few studies have evaluated the vitamin D status (25-hydroxyvitamin D [25(OHD)]) of breastfeeding women and up to now, no information exits for German breastfeeding women. Therefore, the aim of study was to determine the vitamin D status of breastfeeding women compared to non-pregnant and non-breastfeeding (NPNB) women.MethodsThis cross-sectional study investigated 124 breastfeeding women and 124 age and season matched NPNB women from the German “Vitamin and mineral status among German women” study. The study participants were recruited from April 2013 to March 2015 and did not take vitamin D supplements. Serum 25(OH)D was analyzed by chemiluminescent immunoassay.ResultsVitamin D deficiency (<25.0 nmol/L) was prevalent in 26.6% of the breastfeeding women. The majority of women (49.2%) showed 25(OH)D concentration between 25.0 and 49.9 nmol/L. In multiple binary logistic regression analysis, breastfeeding women had a 4.0-fold higher odds ratio (OR) (95% confidence interval [CI] 1.8, 8.7) for vitamin D deficiency than NPNB women. For breastfeeding women, the risk of vitamin D deficiency was higher in the winter and spring months (OR: 2.6, 95% CI 1.1, 6.3) and increased with lower longitude per one unit (OR 0.7, 95% CI 0.6, 0.9).ConclusionBreastfeeding women in Germany had a higher risk of deficient vitamin D levels than NPNB women. In further studies, the optimal vitamin D status for breastfeeding women should be investigated and also the required vitamin D doses to ensure this vitamin D status.Trial registrationGerman Clinical Trial Register (identification number: DRKS00004789).

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Section: Discussionmentioning

confidence: 99%

“…Moreover, the 25(OH)D concentrations may be higher as detected as the measurement by DiaSorin Liaison chemiluminescence immunoassay underestimate the concentration compared with the analysis by LC-MS/MS [34]. However, the underestimating analysis was applied to both breastfeeding women and NPNB women.…”

Section: Discussionmentioning

confidence: 99%

Breastfeeding woman are at higher risk of vitamin D deficiency than non-breastfeeding women - insights from the German VitaMinFemin study

2016

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“…Thus, it may be that this single measurement does not accurately reflect participants' 25(OH)D levels over time. Furthermore, there are also some concerns that the DiaSorin Liaison assay may be more likely to classify people as 25(OH)D deficient than other assays [32]. That said, this assay is widely used, and remains a popular measurement for serum 25(OH)D concentration.…”

Section: Discussionmentioning

confidence: 99%

The Association between Serum 25-Hydroxyvitamin D and Cancer Risk: Results from the Prospective KORA F4 Study

Cheney¹,

Thorand²,

Huth³

et al. 2018

Oncol Res Treat

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Background: Many studies have examined the relationship between vitamin D and specific types of cancer with inconsistent results. Furthermore, to date, no observational studies have demonstrated a clear relationship between vitamin D and total cancer risk. Methods: We analyzed data from a population-based prospective cohort study including 2,003 initially cancer-free participants from the KORA F4 study with baseline serum 25-hydroxyvitamin D (25(OH)D) measurements (surveyed between 2006 and 2008). We used Cox proportional hazard models to assess the association between 25(OH)D levels and incident cancer risk. Results: Within a follow-up period of 7 years, 69 of the participants developed cancer. Overall, we observed no significant relationship between serum 25(OH)D levels and cancer risk. The hazard ratio (HR) per 1 ng/ml increase in 25 (OH)D for this relationship was 1.00 (95% confidence interval (CI) 0.97-1.04) adjusting for age, sex, body mass index, and season of blood draw. This was also true in subgroup analysis for prostate cancer (HR 0.95, 95% CI 0.88-1.03), breast cancer (HR 1.03, 95% CI 0.97-1.09), and colorectal cancer (HR 0.97, 95% CI 0.88-1.07). Conclusion: Our study found no protective effect of 25(OH)D against developing cancer. However, studies with more participants and additional measurements of 25(OH)D are still needed to accurately clarify the relationship between 25(OH)D and total cancer risk.

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“…It has, however, previously been found to report lower 25(OH)D concentrations compared with the liquid chromatography-tandem spectrometry method considered the golden standard (56) . A risk of overestimation of low vitamin D status therefore exists in our study.…”

Section: ·424mentioning

confidence: 99%

Vitamin D status and its determinants during autumn in children at northern latitudes: a cross-sectional analysis from the optimal well-being, development and health for Danish children through a healthy New Nordic Diet (OPUS) School Meal Study

et al. 2015

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Sufficient summer/autumn vitamin D status appears important to mitigate winter nadirs at northern latitudes. We conducted a cross-sectional study to evaluate autumn vitamin D status and its determinants in 782 Danish 8-11-year-old children (55°N) using baseline data from the Optimal well-being, development and health for Danish children through a healthy New Nordic Diet (OPUS) School Meal Study, a large randomised controlled trial. Blood samples and demographic and behavioural data, including 7-d dietary recordings, objectively measured physical activity, and time spent outdoors during school hours, were collected during September-November. Mean serum 25-hydroxyvitamin D (25(OH)D) was 60·8 (SD 18·7) nmol/l. Serum 25(OH)D levels ≤50 nmol/l were found in 28·4 % of the children and 2·4 % had concentrations <25 nmol/l. Upon multivariate adjustment, increasing age (per year) (β −2·9; 95 % CI −5·1, −0·7 nmol/l), female sex (β −3·3; 95 % CI −5·9, −0·7 nmol/l), sampling in October (β −5·2; 95 % CI −10·1, −0·4 nmol/l) and November (β −13·3; 95 % CI −17·7, −9·1), and non-white ethnicity (β −5·7; 95 % CI −11·1, −0·3 nmol/l) were negatively associated with 25(OH)D (all P < 0·05). Likewise, immigrant/descendant background was negatively associated with 25(OH)D, particularly in females (β −16·3; 95 % CI −21·9, −10·7) (P < 0·001) (P interaction = 0·003). Moderate-to-vigorous physical activity (MVPA) (min/d) (β 0·06; 95 % CI 0·01, 0·12), outdoor walking during school hours (min/week) (β 0·4; 95 % CI 0·1, 0·6) and intake of vitamin D-containing supplements ≥3 d/week (β 8·7; 95 % CI 6·4, 11·0) were positively associated with 25(OH)D (all P < 0·05). The high proportion of children with vitamin D status below the recommended sufficiency level of 50 nmol/l raises concern as levels expectedly drop further during winter months. Frequent intake of vitamin D supplements was strongly associated with status. MVPA and outdoor activity during school hours should be investigated further in interventions to improve autumn vitamin D status in children at northern latitudes. Key words: Vitamin D: Children: Northern latitudes: DeterminantsDeterminants of vitamin D status are complex to evaluate but require attention as vitamin D deficiency has been found to occur commonly among, for example, healthy European children and adolescents (1) , and as vitamin D facilitates intestinal Ca absorption and optimal bone health (2,3) . Vitamin D plays a particularly crucial role during childhood growth stages, when accumulation of skeletal Ca increases vastly (4) . The vitamin D metabolite 25-hydroxyvitamin D (25(OH)D) has a half-life of 2-3 weeks, and currently serves as a suitable marker of vitamin D status (5) . Although different cut-off levels are advocated (6) , the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) has recently re-established the recommendation of a 25(OH)D concentration >50 nmol/l (20 ng/ml) to indicate sufficiency (1) . Severe vitamin D deficiency during childhood, established by ESPGHAN as ...

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Variation in clinical vitamin D status by DiaSorin Liaison and LC-MS/MS in the presence of elevated 25-OH vitamin D2

Cited by 38 publications

References 15 publications

Breastfeeding woman are at higher risk of vitamin D deficiency than non-breastfeeding women - insights from the German VitaMinFemin study

Breastfeeding woman are at higher risk of vitamin D deficiency than non-breastfeeding women - insights from the German VitaMinFemin study

The Association between Serum 25-Hydroxyvitamin D and Cancer Risk: Results from the Prospective KORA F4 Study

Vitamin D status and its determinants during autumn in children at northern latitudes: a cross-sectional analysis from the optimal well-being, development and health for Danish children through a healthy New Nordic Diet (OPUS) School Meal Study

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