Variation in coverage by ethnic group of neonatal (Guthrie) screening programme in south London

Streetly, Allison; Grant, Carol; Bickler, Graham; Eldridge, P.; Bird, Steven; Griffiths, William E.

doi:10.1136/bmj.309.6951.372

Cited by 17 publications

(11 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As in our study, retrieval of blood spots was lowest among seriously ill or growth-retarded infants. A descriptive study of newborn screening in London [Streetly et al, 1994] reported that, unlike our results, blood spots were less likely to be collected from African ethnic groups than from white infants and that completeness of screening varied by geographic area.…”

Section: Discussioncontrasting

confidence: 82%

Use of stored newborn blood spots in research on birth defects: Variation in retrieval rates by type of defect and infant characteristics

Loffredo

Ewing

1997

Am. J. Med. Genet.

View full text Add to dashboard Cite

Stored blood spots from state newborn screening programs represent a potential source of DNA for molecular genetics research on birth defects. The stored blood spots of cases and controls from an epidemiologic database on congenital heart defects were sought in the present study, which aimed to establish the feasibility of linking the data sources and to examine blood spot retrieval rates for selected cardiac defects. Blood spots were located on 341 of 522 infants (65%) with congenital heart defects and for 1,484 of 1,645 infants without birth defects (84%) born in Maryland during 1981-1989. Retrieval rates were low among infants with clinically severe lesions such as truncus arteriosus (26%) but were considerably higher in infants with coarctation of the aorta (62%), pulmonic valve stenosis (71%), and atrial septal defect (76%). Retrieval rates were significantly lower for premature and low-birth-weight infants than among full-term, normal-birth-weight infants. Retrieval rates did not vary significantly by gender, race, county of residence, or parental socioeconomic characteristics. These results demonstrate the feasibility of linking epidemiologic databases with stored newborn blood specimens, especially for normal infants and even for infants with certain congenital heart defects, but raise concerns about the adequacy of such methods to obtain stored specimens from premature infants and from those with severe heart defects.

show abstract

Section: Discussioncontrasting

confidence: 82%

Use of stored newborn blood spots in research on birth defects: Variation in retrieval rates by type of defect and infant characteristics

Loffredo

Ewing

1997

Am. J. Med. Genet.

View full text Add to dashboard Cite

show abstract

“…HIV-1 prevalence data were obtained from the unlinked anonymous dried blood spot survey and published neonatal screening uptake (coverage) levels were used for the district health authorities which correspond to these boroughs: West Lambeth and Camberwell [16]. Population statistics for the boroughs were obtained from the 1991 Census [20] and fertility statistics for England and Wales from 1991 OPCS Birth Statistics [21].…”

Section: Methodsmentioning

confidence: 99%

“…Fertility data were taken as 160/1000 for African mothers and 60/1000 for all other mothers respectively as shown in Table 1 [21]. Coverage was taken as 95-6 % for African mothers and 98 15 % for all other mothers [16].…”

Section: Methodsmentioning

confidence: 99%

“…However, uptake of testing (coverage) is often incomplete [11,12,14,15], with differential coverage in ethnic groups. One recent audit survey in two deprived areas in the South of London, England found that coverage levels among babies born to women of ethnic group black african (referred to henceforth as African) was 95 6 % compared to 98&2 % for babies born to women from all other ethnic groups thus giving a relative inclusion ratio (RIR) of 0975 for African mothers versus all other mothers for whom ethnic group was known [16]. (The RIR is the probability that a sample with a particular characteristic is included in a survey compared to one without the characteristic).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of incomplete coverage of neonatal dried blood spot screening on estimating HIV-1 seroprevalence

Hutchinson¹,

Streetly

Grant

et al. 1996

Epidemiol. Infect.

View full text Add to dashboard Cite

SUMMARYThe aim of this study was to determine the extent to which selective under-coverage of births to mothers more likely to be at risk of HIV-1 infection will result in a significant underestimation of the true neonatal seroprevalence. Census data, local birth statistics, maternity data and data from the prevalence monitoring programme were used to produce a model to predict the effects of under-coverage in the uptake of neonatal metabolic screening which has been observed in babies with a mother of ethnic group black African. The adjustment factor which allows for under-coverage is the relative inclusion ratio (RIR); the probability that samples from a group at different risk of HIV infection were included in the survey divided by the probability of inclusion for samples from all other babies. The RIR was found to be close to unity (0 97), indicating a minimal bias. Under usual conditions only if the relative inclusion ratio (RIR) declined to values of 0'87 or below would there be a substantial bias. Despite some selective under representation, the results obtained from the Unlinked Anonymous HIV

show abstract

“…A further study looked at the variation in screening coverage by ethnic group and found that it was incomplete in African infants and in families mobile at the time of birth. It identified problems in recording results, follow up of infants not tested, and monitoring of the programme 9. Both studies recommend that explicit process measures should be introduced to address these problems and monitor the screening programme through audit.…”

mentioning

confidence: 99%

Audit of neonatal screening programme for phenylketonuria and congenital hypothyroidism

Simpson

Randall²,

Lenton³

et al. 1997

Archives of Disease in Childhood - Fetal and Neonatal Edition

View full text Add to dashboard Cite

The performance of the neonatal screening programme was audited against clinical standards in the Bath clinical area from 1 April 1994 to 31 March 1996. The standards and policy were agreed by local service provider representatives of the screening and were audited, using laboratory and child health computer systems and medical records. Two annual reports were produced with recommendations for improvement communicated to representatives of the service. Thus the first audit loop has been completed.The audit shows that the coverage of the service is excellent, with all eligible babies being oVered screening; those with congenital hypothyroidism or phenylketonuria receive appropriate treatment by the 28 day standard. The process works extremely well, although areas for improvement have been identified, to increase the eYciency of the service.It is concluded that an eVective and eYcient audit cycle can be established, to monitor and improve the performance of the neonatal screening service. (Arch Dis Child 1997;77:F228-F234)

show abstract

Variation in coverage by ethnic group of neonatal (Guthrie) screening programme in south London

Cited by 17 publications

References 11 publications

Use of stored newborn blood spots in research on birth defects: Variation in retrieval rates by type of defect and infant characteristics

Use of stored newborn blood spots in research on birth defects: Variation in retrieval rates by type of defect and infant characteristics

Impact of incomplete coverage of neonatal dried blood spot screening on estimating HIV-1 seroprevalence

Audit of neonatal screening programme for phenylketonuria and congenital hypothyroidism

Contact Info

Product

Resources

About