Variation in Hepatic Estrogen Receptor Concentrations in Patients with Liver Disease a Multivariate Analysis

Becker, Ulrik; Andersen, Jørn; Poulsen, Hans Skovgaard; Horn, Thomas

doi:10.3109/00365529209000087

Cited by 7 publications

(1 citation statement)

References 25 publications

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“…Higher levels (although still below the levels found in target tissues) have been reported in male subjects abusing alcohol; this has been interpreted as a possible mechanism for the biochemical feminization observed in alcoholic chronic liver disease [42]. However, this finding has been disputed by other authors using a different method of detection of ERs and studying patients with far more advanced disease [43].…”

Section: Mechanisms Of Estrogens' Actionmentioning

confidence: 99%

Role of Estrogen in Liver Cancer

Villa

2008

Womens Health (Lond Engl)

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Liver cancer is the fifth most common cancer worldwide and despite increasing implementation of ultrasonographic surveillance strategies, its incidence is rising, especially in western countries. A universal characteristic of hepatocellular carcinoma is the striking male prevalence that is found, with few exceptions, both in animals and in humans. Many different hypotheses have been put forward in an attempt to explain this finding, which is not a simple epidemiological oddity but could also have pathogenetic implications. An obvious trail to follow, as gender susceptibility is implicated, is the role played by sex hormones, namely estrogens. Estrogens are not simply involved in reproductive mechanisms; instead, it is increasingly evident that they have a role in such an enormous variety of cellular processes that their implication in liver carcinogenesis may be manifold. The purpose of this review is to provide an overview of the available data, with a special focus on the hormonal mechanisms potentially implicated in the development of liver cancer.

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Section: Mechanisms Of Estrogens' Actionmentioning

confidence: 99%

Role of Estrogen in Liver Cancer

Villa

2008

Womens Health (Lond Engl)

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Hepato‐cellular Failure

Sherlock¹,

Dooley²

2001

Diseases of the Liver and Biliary System

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Steroid receptors and heat-shock proteins in patients with primary biliary cirrhosis

et al. 1993

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Primary biliary cirrhosis has a definite female preponderance. Increased estrogen levels have been found in patients with this disease; however no studies indicate the status of sex hormone steroid receptors in primary biliary cirrhosis patients. In this study the occurrence and distribution of estrogen receptors, progesterone receptors and androgen receptors in liver biopsy specimens from patients with primary biliary cirrhosis were examined and compared with these receptors in the normal liver. In addition, three heat-shock proteins associated with steroid receptors (90 kD, 70 kD and 27 kD) were examined. All of the receptor proteins were detected on immunocytochemical study using specific receptor antibodies; monoclonal and polyclonal antibodies were also used to detect the heat-shock proteins. Normal bile duct epithelial cells displayed low-to-moderate amount of estrogen receptors and abundant 90- kD, 70- kD and 27-kD heat-shock protein expression, whereas normal hepatocytes showed moderate estrogen receptor and 90-kD heat-shock protein and high 70-kD heat-shock protein expression. Expression of 70-kD heat-shock protein was due mainly to the constitutive form of this protein (hsc72). In patients with primary biliary cirrhosis, significant increases in estrogen receptor and 90-kD heat-shock protein content were seen in bile duct cells and in hepatocytes. Levels of 27-kD heat-shock protein were also increased in some of the primary biliary cirrhosis biopsy specimens. The expression of progesterone receptor and androgen receptor was very low in normal and primary biliary cirrhosis bile duct cells and hepatocytes.(ABSTRACT TRUNCATED AT 250 WORDS)

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Variation in Hepatic Estrogen Receptor Concentrations in Patients with Liver Disease a Multivariate Analysis

Cited by 7 publications

References 25 publications

Role of Estrogen in Liver Cancer

Role of Estrogen in Liver Cancer

Hepato‐cellular Failure

Steroid receptors and heat-shock proteins in patients with primary biliary cirrhosis

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