Variation in natural exposure to anopheles mosquitoes and its effects on malaria transmission

Guelbéogo, Wamdaogo Moussa; Gonçalves, Bronner P.; Grignard, Lynn; Bradley, John; Sermé, Samuel Sindié; Hellewell, Joel; Lanke, Kjerstin; Zongo, Soumanaba; Sepúlveda, Nuno; Soulama, Issiaka; Wangrawa, Dimitri W.; Yakob, Laith; Sagnon, N’Falé; Bousema, Teun; Drakeley, Chris

doi:10.7554/elife.32625

Cited by 75 publications

(76 citation statements)

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“…coluzzii was detectable over a range of 250 metres [22]. Heterogeneity in mosquito biting rates has been demonstrated to be key to malaria transmission, first by theoretical work [23], but more recently with empirical studies using genotyping of blood-meals [24]. Future modelling frameworks will need to account for this additional form of village-level heterogeneity in biting behaviour.…”

Section: Discussionmentioning

confidence: 99%

A systematic review and meta-analysis of the human blood index of the major African malaria vectors

Orsborne

Furuya‐Kanamori

et al. 2018

Preprint

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The proportion of mosquito blood-meals that are of human origin, referred to as the 'human blood index' or HBI, is a key determinant of malaria transmission. We conducted a systematic review of the HBI for the major African malaria vectors. Evidence is presented for higher HBI among Anopheles gambiae (M/S forms and An. coluzzii/An. gambiae s.s. are not distinguished for most studies and therefore combined) as well as An. funestus when compared with An. arabiensis (prevalence odds ratio adjusted for whether mosquitoes were caught indoors and outdoors: 1.61 95%CI 1.08-2.39; 1.84 95%CI 1.35-2.52, respectively). This finding is in keeping with the entomological literature which describes An. arabiensis to be more zoophagic than the other major African vectors. However, metaanalysis also revealed that HBI was more associated with location of mosquito captures (indoors versus outdoors, R 2 =0.3) than with mosquito (sibling/) species (R 2 =0.11), and that this difference was significant (p<0.01). Some of the more important consequences of mosquito biting behaviour are discussed in the context of new theoretical and empirical developments that may improve both HBI assessment and how this metric can inform malaria control optimisation.

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Section: Discussionmentioning

confidence: 99%

A systematic review and meta-analysis of the human blood index of the major African malaria vectors

Orsborne

Furuya‐Kanamori

et al. 2018

Preprint

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“…Individuals may differ in their exposure to blackfly bites due to their attractiveness to flies [24], occupation [25,26] or age and sex [21,27]. Variation in exposure to vector bites has received theoretical and empirical attention in the context of lymphatic filariasis [28,29], schistosomiasis [30] and malaria [31,32] but is less well studied for onchocerciasis (although see [33]). In lymphatic filariasis, high levels of exposure heterogeneity are associated with increased resilience to MDA, allowing parasite persistence at low prevalence [28].…”

Section: Introductionmentioning

confidence: 99%

Modelling exposure heterogeneity and density dependence in onchocerciasis using a novel individual-based transmission model, EPIONCHO-IBM: Implications for elimination and data needs

et al. 2019

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Background Density dependence in helminth establishment and heterogeneity in exposure to infection are known to drive resilience to interventions based on mass drug administration (MDA). However, the interaction between these processes is poorly understood. We developed a novel individual-based model for onchocerciasis transmission, EPIONCHO-IBM, which accounts for both processes. We fit the model to pre-intervention epidemiological data and explore parasite dynamics during MDA with ivermectin. Methodology/Principal findings Density dependence and heterogeneity in exposure to blackfly (vector) bites were estimated by fitting the model to matched pre-intervention microfilarial prevalence, microfilarial intensity and vector biting rate data from savannah areas of Cameroon and Cô te d'Ivoire/Burkina Faso using Latin hypercube sampling. Transmission dynamics during 25 years of annual and biannual ivermectin MDA were investigated. Density dependence in parasite establishment within humans was estimated for different levels of (fixed) exposure heterogeneity to understand how parametric uncertainty may influence treatment dynamics. Stronger overdispersion in exposure to blackfly bites results in the estimation of stronger density-dependent parasite establishment within humans, consequently increasing resilience to MDA. For

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“…In general, the method based on silica particles relies on nucleic acids binding to the silica surface in the presence of chaotropic salts, like guanidinium thiocyanate (GuSCN) or guanidinium hydrochloride (GuHCl) (Boom et al 1990;Li et al 2010). This approach proves to be versatile because it was used to purify plasmid DNA from E. coli, for detection of the potato virus Y or in isolating DNA from blood consumed by mosquitoes (Guelbéogo et al 2018;Li et al 2010;Zacharzewska et al 2014). In contrast to highly optimized and efficient but expensive commercial kits, the silica-based method can be easily adapted to individual sub-protocols.…”

Section: Introductionmentioning

confidence: 99%

Isolation of nucleic acids using silicon dioxide powder as a tool for environmental monitoring

Urbaniak¹,

Janowski

Jacewski³

2019

Environ Monit Assess

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Isolation and purification of nucleic acids are basic laboratory procedures used in molecular analysis supporting determination of organisms in environmental monitoring. However, many different methods of isolation are commonly used, often being designed for a particular type of DNA extraction. While researchers commonly decide on commercial isolation kits for their ease of use and efficiency, they require large amounts of studied tissue, and the cost of purchasing such kits over a long run can be high. To provide an alternative to using commercial kits, we have developed a simple, rapid, cost-effective, and reliable protocol for DNA isolation from cultured fungi on slants and from dried fungal samples using silica particles (silicon dioxide powder) in chaotropic conditions. With the presented method, it is possible to isolate good-quality DNA from fungi in less than 1.5 h, using easily accessible chemicals. Compared with other methods employing CTAB or commercial kits, it allows fast, easy, and cheap DNA purification from two main sources of fungi routinely used for research. In addition to the method protocol, we also provide advice for further optimization of the isolation process to account for specific conditions, making the procedure more useful.

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Variation in natural exposure to anopheles mosquitoes and its effects on malaria transmission

Cited by 75 publications

References 50 publications

A systematic review and meta-analysis of the human blood index of the major African malaria vectors

A systematic review and meta-analysis of the human blood index of the major African malaria vectors

Modelling exposure heterogeneity and density dependence in onchocerciasis using a novel individual-based transmission model, EPIONCHO-IBM: Implications for elimination and data needs

Isolation of nucleic acids using silicon dioxide powder as a tool for environmental monitoring

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