Digital human models are often used for ergonomic analysis of product designs, before physical prototypes are available. However, existing digital human models cannot be used to simultaneously: 1) consider the tissue loads and the physiological effects of the tissue loads; 2) optimise the product properties. This paper develops multi-dimensional digital human models for ergonomic analysis based on natural data representations, which include anatomy, morphology, behaviour, physiology, tissue, and posture data representations. The results show that the multi-dimensional digital human models can be used to: 1) accelerate the design process; 2) assess mechanical and physiological loads inside the body and in the contact area between the body and the product; 3) optimise the quality of the product; 4) reduce the number of user trials needed to create the product.