Variation in the CXCR1 gene (IL8RA) is not associated with susceptibility to chronic periodontitis

Scarel‐Caminaga, Raquel Mantuaneli; Curtis, Karen M. C.; Renzi, Rivelto; Sogumo, Patrícia Mayumi; Anovazzi, Giovana; Viana, Aline Cavalcanti; Kim, Yeon Jung; Orrico, Silvana Regina Perez; Cirelli, Joni Augusto

doi:10.1186/1477-5751-10-14

Cited by 10 publications

(9 citation statements)

References 43 publications

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“…For instance, MO‐BN reveals that a cxcr1 SNP (Rs2234671) plays a dual role in RP2 and LC responses. This is corroborated by literature where it was reported that the cxcr1 SNP mediates inflammatory response through IL‐8, and it was also found to predict tumor response . Moreover, miRNAs in our MO‐BNs act as master regulators of biophysical pathways.…”

Section: Discussionsupporting

confidence: 88%

A multiobjective Bayesian networks approach for joint prediction of tumor local control and radiation pneumonitis in nonsmall‐cell lung cancer (NSCLC) for response‐adapted radiotherapy

et al. 2018

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Section: Discussionsupporting

confidence: 88%

A multiobjective Bayesian networks approach for joint prediction of tumor local control and radiation pneumonitis in nonsmall‐cell lung cancer (NSCLC) for response‐adapted radiotherapy

et al. 2018

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“…Regarding the −1026 SNP, we found that individuals carrying the (AC) or (AA) genotypes were more susceptible to CP. However, similar to other studies [ 36 , 38 ], this genetic association was not maintained after the adjustments for covariates in the multiple logistic regression analysis. Multiple logistic regressions were used here to evaluate the influence of common (and other potential) covariates, in the association of each NOS2 SNP with CP.…”

Section: Discussionsupporting

confidence: 83%

Inducible Nitric Oxide Synthase Polymorphisms and Nitric Oxide Levels in Individuals with Chronic Periodontitis

Scarel‐Caminaga

Flávia

Pigossi

et al. 2017

IJMS

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This study aimed to investigate whether the −1026(A>C)(rs2779249) and +2087(A>G)(2297518) polymorphisms in the NOS2 gene were associated with chronic periodontitis (CP) and with salivary levels of nitrite (NO2−) and/or nitrate + nitrite (NOx). A group of 113 mixed-race patients were subjected to periodontal, genetic, and biochemical evaluations (65 CP/48 periodontally healthy subjects). DNA was extracted from oral epithelial cells and used for genotyping by polymerase chain reaction (real-time). Salivary NOx concentrations were determined using an ozone-based chemiluminescence assay. Association of CP with alleles and genotypes of the −1026(A>C) polymorphism was found (X2 test, p = 0.0075; 0.0308), but this was not maintained after multiple logistic regression, performed to estimate the effect of covariates and polymorphisms in CP. This analysis demonstrated, after correction for multiple comparisons, that only the female gender was significantly associated with CP. Polymorphisms analyzed as haplotypes were not associated with CP. NOx levels were significantly higher in the control group of heterozygous individuals for both polymorphisms. In conclusion, the female gender was significantly associated with CP, and higher levels of salivary NOx were found in control subjects and associated with the heterozygous state of the NOS2 polymorphisms, reinforcing the potential of NO metabolites as markers of periodontitis status.

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“…One study [ 20 ] involving rs2234671 polymorphism showed it was not related to periodontitis risk (C vs. G: OR = 1.10, 95%CI = 0.67–1.79, p = 0.71; CG+CC vs. GG: OR = 1.12, 95%CI = 0.66–1.90, p = 0.68).…”

Section: Resultsmentioning

confidence: 99%

Comprehensive analysis of interleukin-8 gene polymorphisms and periodontitis susceptibility

Cheng

et al. 2017

Oncotarget

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BackgroundAssociations between interleukin-8 (IL-8) gene polymorphisms and periodontitis susceptibility have been investigated in many published studies, but the conclusions are still inconsistent. Therefore, we performed this systematic review and meta-analysis to review which polymorphisms have been researched and to obtain a precise result of the same polymorphism from different studies.ResultsFinally 10 publications involving 1938 patients and 1569 controls were yielded, including 12 polymorphisms. Six studies investigated rs4073 polymorphism; two focused on rs2227306 and rs2227307; two referred to rs2227532 and T-738A; one detected rs2230054, rs1126579 and rs1126580; one inspected A2767T, T11722T2 and C1633T, and one for rs2234671 polymorphism. Of them, IL-8 C1633T and rs1126580 polymorphisms showed positive association while the other ten polymorphisms revealed negative results.Materials and methodsA comprehensive literature search from PubMed, Web of Science, and Chinese National Knowledge Infrastructure was conducted for all potentially relevant studies published before January 2, 2017. Two authors selected the studies and extracted data. The pooled analysis was conducted using the RevMan 5.1 software if a polymorphism was reported by two or more studies.ConclusionsBased on current evidence, the IL-8 rs4073, A2767T, T11722T2, rs2234671, rs2230054, rs1126579, rs2227306, rs2227307, rs2227532, and T-738A polymorphisms were not associated with periodontitis susceptibility; the IL-8 C1633T and rs1126580 polymorphisms were associated with increased risk of periodontitis.

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Variation in the CXCR1 gene (IL8RA) is not associated with susceptibility to chronic periodontitis

Cited by 10 publications

References 43 publications

A multiobjective Bayesian networks approach for joint prediction of tumor local control and radiation pneumonitis in nonsmall‐cell lung cancer (NSCLC) for response‐adapted radiotherapy

A multiobjective Bayesian networks approach for joint prediction of tumor local control and radiation pneumonitis in nonsmall‐cell lung cancer (NSCLC) for response‐adapted radiotherapy

Inducible Nitric Oxide Synthase Polymorphisms and Nitric Oxide Levels in Individuals with Chronic Periodontitis

Comprehensive analysis of interleukin-8 gene polymorphisms and periodontitis susceptibility

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