Variation in the Type of Immune Response to Mouse Histocompatibility Antigens as the Function of Their Form

Experimental Models for Prevention of Graft-versus-Host Reaction in Bone Marrow Transfusion

“…The inability of such a treatment of donors to suppress completely the occurrence of GVH reaction in an H-2 identical combination may be ascribed to a poor efficiency of such an antigenic stimulation to induce antibody production against minor histocompatibility antigens and M locus antigen. This explana tion may be in agreement with the general concept that the induction of antibody pro duction against minor histocompatibility an tigens is rather difficult in various experi mental systems [2]. In an H-2 nonidentical combination, repeated pretreatments of hosts even with viable allogeneic cells sup press more or less the rejection of allografts derived from the same strains of donors, al though suppression of GVH reaction by re peated treatments of the AKR donors with viable spleen cells of C57BL/6 mice was rather weak in (AKR X C57BL/6) FI re cipients in our preliminary experient.…”

“…In an H-2 nonidentical combination, repeated pretreatments of hosts even with viable allogeneic cells sup press more or less the rejection of allografts derived from the same strains of donors, al though suppression of GVH reaction by re peated treatments of the AKR donors with viable spleen cells of C57BL/6 mice was rather weak in (AKR X C57BL/6) FI re cipients in our preliminary experient. Such suppression may be ascribed also to the pro duction of enhancing antibodies, which have proven to block a cytotoxic effect of killer lymphocytes under various conditions [2]. In an H-2 identical combination, repeated treatments of C3H/He mice with viable AKR spleen cells gave rise to a high degree of cytotoxicity in spleen cells and facilitated the induction of cytotoxicity in spleen cells of FI recipients after transfer of such cells.…”

The Involvement of Activated Specific Suppressor T Cells in Maintenance of Transplantation Tolerance

“…The success of tolerance induction depends on a number of variables which at the same time determine the graft destructive capacity: individual responsiveness, the strength of the H-barrier, the sex of the responders, the immunogenicity of the antigenic preparation due to its form (for review see Hilgert 1974). We are inclined to believe that the common denominator of the effect of such different factors is the activation of the suppressor mechanism which may quantitatively differ from one situation to the other.…”

Adult Transplantation Tolerance Induced by Lentil Lectin: Iii. Induction of Transplantation Tolerance by Lentil Lectin in Mouse Strain Combinations With Different H‐2 Disparities: Tolerogenic Effect of H‐2d Region Antigens

“…However, it is apparent that the histocompatibility differences between the donor and recipient which appear similar according to the simple rejection time criterion were not necessarily equivalent for tolerance induction. The efficiency of tolerance induction is dependent on the quantity and class of histocompatibility antigens present on the allogeneic cells used for tolerance induction (cell suspension or cell extract) or tissue (skin, heart or kidney grafts): for review see Hilgert (1974) and McKenzie (1973). There are marked differences in the expression of antigens encoded by different loci of the H-2 complex on the cells used for induction of tolerance (Hammerling, 1976;Tartakovsky et al, 1980).…”