Variation in Transcutaneous Bilirubin Nomograms across Population Groups

Kaplan, Michael; Bromiker, Ruben

doi:10.1016/j.jpeds.2019.01.036

Cited by 12 publications

(10 citation statements)

References 42 publications

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“…It was necessary to create a new nomogram for Myanmar rather than adopt a nomogram from another country because the level of hyperbilirubinemia varies among different ethnicities 16 . A comparison of the TcB nomogram across different ethnicities shows that Myanmar newborns had higher TcB values than those of other races until 72 h after birth (Figure 2).…”

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confidence: 99%

“…There is a good correlation between TcB measurements obtained using the JM‐103 and TSB levels 7,8 . Many countries have developed their own nomogram for management of neonatal hyperbilirubinemia 6,9–15 because the level of hyperbilirubinemia varies among different ethnicities 16 . However, to date, no TcB nomogram has been developed for the effective management of severe hyperbilirubinemia in infants born in Myanmar.…”

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confidence: 99%

“…7,8 Many countries have developed their own nomogram for management of neonatal hyperbilirubinemia 6,9-15 because the level of hyperbilirubinemia varies among different ethnicities. 16 However, to date, no TcB nomogram has been developed for the effective management of severe hyperbilirubinemia in infants born in Myanmar. If severe hyperbilirubinemia is detected during the early neonatal period, it is possible to avoid a blood exchange transfusion for the prevention of acute bilirubin encephalopathy.…”

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confidence: 99%

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Hour‐specific nomogram for transcutaneous Bilirubin in newborns in Myanmar

Yasuda¹,

Suzuki

Htun³

et al. 2020

Pediatrics International

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Background: Neonatal hyperbilirubinemia is a significant health problem in Myanmar, and the rate of kernicterus is also higher than in developed countries. Non-invasive methods for early detection and treatment of hyperbilirubinemia are urgently needed. In this study, we used transcutaneous bilirubin (TcB) measurements to develop an hour-specific TcB nomogram for the effective management of hyperbilirubinemia in Myanmar newborns. Methods: The bilirubin levels of neonates born in Central Women Hospital in Yangon, Myanmar were measured three times a day within 72 h after birth using a transcutaneous bilirubinometer. An hour-specific TcB nomogram was created based on the data. Results: Participants were 512 infants (287 boys, 225 girls) born in Central Women's Hospital in Yangon. The mean (AESD) gestational age was 38.4 AE 1.2 weeks; birthweight was 3078 AE 412 g. A total of 3,039 plots were obtained, and the TcB nomogram was created with smoothed percentile curves (97.5th, 50th, and 2.5th percentiles) for 0-72 h after birth. Conclusions: An hour-specific TcB nomogram was successfully created to manage hyperbilirubinemia in Myanmar newborns.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Hour‐specific nomogram for transcutaneous Bilirubin in newborns in Myanmar

Yasuda¹,

Suzuki

Htun³

et al. 2020

Pediatrics International

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“…Most of the newborn babies with an age of ≥35 gestational weeks have some degree of jaundice in the 1st day after birth. [ 16 ] Neonatal jaundice is generally not harmful and is a self-limiting condition. However, very high levels of bilirubin, a condition called kernicterus, can cause permanent brain damage.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the relationship between transcutaneous bilirubin measurement and total serum bilirubin in neonatal patients followed for jaundice

Çat¹

2020

Sisli Etfal

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N eonatal jaundice is one of the most common conditions in newborns. [1] This situation can be seen in approximately 60% of term babies and 80% of preterm babies. [2] Neonatal jaundice is a normal physiological condition that usually occurs in the transition period after birth. It is also not a singular disease, but a physical finding associated Objectives: Jaundice is a physiological condition caused by hyperbilirubinemia, which is common in neonatal period. However, severe hyperbilirubinemia can cause kernicterus, which is a serious condition that leads to neurological problems. In this study, we aimed to investigate whether it is safe to use transcutaneous bilirubin (TcB) instead of blood for the evaluation of jaundice by comparing TcB measurement with standard total serum bilirubin (TSB) measurement values. Methods: A total of 105 term and early term infants with gestational ages between 37 and 42 weeks were included in the study. MBJ20 TcB measuring device was used for TcB measurement. TcB was measured from the forehead and sternum. To evaluate the relationship between TcB measurements and TSB measurements, we performed Pearson correlation, Spearman correlation, linear regression analysis, and Bland-Altman analysis in which we evaluated the scatter plot of the differences between the average values of the measurements. Results: There was a positive and statistically significant correlation between TcB forehead and TSB measurements and TcB sternum and TSB measurements (p<0.001). Linear regression analysis showed a positive directional correlation between TcB forehead and TSB measurements (R²=0.85) and TcB sternum and TSB measurements (R²=0.87). Bland-Altman analysis showed a good consistency between TSB and TcB forehead measurement methods (mean difference: 0.39±1.46, 95% CI: [−2.47]-[3.26]), and between TSB and TcB sternum measurement methods (mean difference: 0.49±1.32 95% CI: [−2.1]-[3.07]). Conclusion:As a result of our study, we found that TcB measurement can be reliable instead of taking blood for jaundice evaluation.

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“…classification indicated in the Bhuthani nomogram, which is divided into four zones: low risk, low intermediate risk, high intermediate risk and high risk37,38 . Screening using tracutaneous icterometers is usually done in comparison with this nomogram, as stipulated by the AAP, but this technique may present discrepancies according to the population analyzed, as shown byOlusanya, Imosemi and …”

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confidence: 99%