Variation in visual acuity within pigmented, and between pigmented and albino rat strains

Prusky, Glen T.; Harker, K. Troy; Douglas, Robert M.; Whishaw, Ian Q.

doi:10.1016/s0166-4328(02)00126-2

Cited by 275 publications

(210 citation statements)

References 29 publications

(36 reference statements)

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“…Our results also replicate findings reported by Prusky et al (2002), that the visual acuity of the FBNF1 strain of rats clusters at about ~ 1.5 cpd. The rats in the present study with visual acuity of ~ 1.5 cpd, however, were 14 months of age while the rats tested by Prusky et al, (2002) were under 6 months of age.…”

Section: Discussionsupporting

confidence: 92%

“…By comparing the present findings pertaining to the visual acuity of the FBNF1 strain of rats to those reported by Prusky et al (2002) we can draw two additional conclusions: (1) that there are no changes in visual acuity up to the 14 months of age in this strain of rat, and (2) that the drop in acuity occurs somewhere between 14 month and 2 years of age.…”

Section: Discussionsupporting

confidence: 74%

“…The rats in the present study with visual acuity of ~ 1.5 cpd, however, were 14 months of age while the rats tested by Prusky et al, (2002) were under 6 months of age.…”

Section: Discussionmentioning

confidence: 56%

“…Notwithstanding the significant difference in the grating acuity, it is important to note that the acuity of old FBNF1 rats (age > 24 months; 1.36 cpd) is still much better than the acuity of young adult pigmented rats (such as the Long-Evans rat for example), which clustered around 1.0 cpd (Prusky et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

“…Previously, Prusky et al (2002) measured grating acuity of three pigmented and three albino laboratory strains, and a wild strain. The acuity of the albino strains was the lowest, around 0.5 cycles per degree (cpd).…”

Section: Introductionmentioning

confidence: 99%

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The aging hippocampus: A multi-level analysis in the rat

et al. 2006

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The purpose of the current thesis was twofold: (1) to examine various factors that might be contributing to age-related learning and memory deficits specifically related to the hippocampus, and (2) to validate our rat model of aging, employing a multilevel analysis. We found age-related deficits on both spatial and non-spatial hippocampus-dependent tasks that were accompanied by structural alterations observed both in vivo (volume, but not neuronal metabolic function) and post mortem (neuronal density and neurogenesis, but not synaptic or mitochondrial density). Furthermore, our results suggest that the observed hippocampal structural changes, namely decreased volume and neurogenesis, predict learning and memory deficits, and both can be accounted for by neurogenic reduction. In addition, the above-mentioned pattern of age-related deficits closely resembles that seen in humans, suggesting the present rat version of aging to be a very useful model for investigating hippocampal aging in humans.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 74%

“…The rats in the present study with visual acuity of ~ 1.5 cpd, however, were 14 months of age while the rats tested by Prusky et al, (2002) were under 6 months of age.…”

Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The aging hippocampus: A multi-level analysis in the rat

et al. 2006

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Rodent Model of Attention: The 5‐Choice Serial Reaction Time Task

Higgins

Breysse

2008

CP Pharmacology

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The 5-choice serial reaction time task (5-CSRTT) is the most widely used test to measure attentional performance in rodents. The basic test design involves training animals to respond to a brief visual stimulus presented unpredictably in one of five locations. Once trained to stable performance levels, the effects of experimental manipulations on response speed and choice accuracy are measured and each are related to attentional performance. Increasingly, the test is also used to examine aspects of response control. Having been adapted from a human task, the test has also been successfully extended to the mouse and primate, thus highlighting its translational value. Increasingly this test is being applied in drug discovery efforts, primarily to identify novel drug treatments for conditions associated with attention deficits.

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Social Recognition Assay in the Rat

Mathiasen¹,

DiCamillo²

2010

CP Neuroscience

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Neuropsychiatric disorders encompass a broad patient population in a variety of disease states across all age groups and are often accompanied by deficits in short-term/working memory. However, most preclinical models that allow for an assessment of cognitive enhancement do not provide robust behavioral readouts with a level of throughput sufficient to support modern drug discovery efforts. The rat social recognition assay presented in this unit is one exception that has been increasingly employed to test new chemical entities for enhancing cognitive activity. The test is simple in design and takes advantage of the spontaneous behavior of rats to investigate conspecifics. The protocol in this unit is designed to evaluate the effects of a test substance on the short-term/working memory of adult male rats employing 30-min or 2-hr pretreatment times.

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Variation in visual acuity within pigmented, and between pigmented and albino rat strains

Cited by 275 publications

References 29 publications

The aging hippocampus: A multi-level analysis in the rat

The aging hippocampus: A multi-level analysis in the rat

Rodent Model of Attention: The 5‐Choice Serial Reaction Time Task

Social Recognition Assay in the Rat

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