Variation of bispectral index monitoring in paediatric patients undergoing propofol-remifentanil anaesthesia

Abstract

At loss of consciousness and regaining of consciousness, the bispectral index values of younger children group are significantly higher than those of adults. At the same stable concentrations of propofol, the bispectral index values are significantly different between children and adults. This study suggests that there is deviation when the adult algorithm of bispectral index monitoring is applied in paediatric patients under intravenous anaesthesia.

A randomized trial of propofol consumption and recovery profile with BIS‐guided anesthesia compared to standard practice in children

“…Liu et al. (13) observed that at loss of consciousness, at regaining of consciousness, and at the same stable concentrations of propofol, the BIS values were significantly higher in children than in adults. Tirel et al.…”

“…Some authors have shown variation in BIS values with age using both inhalational agents as well as propofol (8,9,21,22). Liu et al (13) observed that at loss of consciousness, at regaining of consciousness, and at the same stable concentrations of propofol, the BIS values were significantly higher in children than in adults. Tirel et al (9) explored the relationship between age and BIS values at different plasma concentrations of propofol.…”

“…Propofol is an anesthetic agent that is now being used for sedation and general anesthesia in children (8–10). Few studies in children have evaluated BIS under total intravenous anesthesia (TIVA) with propofol (9,11–13). Weber et al.…”

“…Propofol is an anesthetic agent that is now being used for sedation and general anesthesia in children (8)(9)(10). Few studies in children have evaluated BIS under total intravenous anesthesia (TIVA) with propofol (9,(11)(12)(13). Weber et al (12) reported reduced propofol consumption and faster emergence in children during TIVA with propofol ⁄ remifentanil using auditory evoked potential (AEP).…”

Impact of Bispectral Index for monitoring propofol remifentanil anaesthesia. A randomised clinical trial

“…Before study start, we produced 252 sealed opaque envelopes, each containing an individual project identification code for each patient that will be included (Age group -Operation subgroup -Arm BIS/control -Sequential number [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. The envelopes were coded and subdivided according to the stratification planned for the study (Age -Operation type), resulting in nine groups of 28 envelopes each.…”